Gago-López, Nuria Lagunas Arnal, Carmen Perez, Juan J Wagner, Erwin F
Published in
Experimental dermatology
Psoriasis is a chronic inflammatory skin disease without cure. Systemic and biological therapies are the most effective treatments for patients with severe psoriasis. However, these drugs can cause serious side effects from extended use. Safe and effective topical drugs are needed to decrease psoriatic plaques and reduce the risk of adverse effects...
Hao, Guixia McCormick, Susan Vaughan, Martha M
Published in
Phytopathology
Fusarium graminearum is the causal agent of Fusarium head blight (FHB), which reduces crop yield and contaminates grains with poisonous trichothecene mycotoxins, including deoxynivalenol (DON). DON functions as an important virulence factor that promotes FHB spread in wheat; therefore, reducing DON production will decrease yield losses to FHB and i...
Chen, Gang Ullah, Aftab Xu, Gang Xu, Zhou Wang, Fei Liu, Tianqing Su, Yi Zhang, Tangjie Wang, Kaikai
Published in
Drug Delivery
Transdermal drug delivery for local or systemic therapy provides a potential anticancer modality with a high patient compliance. However, the drug delivery efficiency across the skin is highly challenging due to the physiological barriers, which limit the desired therapeutic effects. In this study, we prepared liposome-in-hydrogels containing a tum...
Zivanovic, Marija Chen, Zhi-Yuan
Published in
Phytopathology
Cercospora leaf blight (CLB), primarily caused by Cercospora cf. flagellaris, is one of the most important diseases of soybean (Glycine max) in Louisiana. The pathogen produces cercosporin, a nonspecific toxin and an important virulence factor. There are no commercial cultivars with CLB resistance, and the pathogen has developed substantial resista...
He, Chunbo Wang, Xiaoli Zhang, Jing Wang, Hao Zhao, Yaofeng Shah, Jagat Narayan Ma, Chan Li, Hailan Su, Wenting Zhang, Zhe
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Published in
Basic & clinical pharmacology & toxicology
Chimeric peptide MCRT (YPFPFRTic-NH2 ) was a multifunctional ligand of opioid and neuropeptide FF (NPFF) receptors and reported to be potentially antalgic in acute tail-flick test. Here, we developed spared nerve injury (SNI) model to explore its efficacy in chronic neuropathic pain. Analgesic tolerance, opioid-induced hyperalgesia and gastrointest...
Kusumaningsih, Tuti Irmawati, Anis Ernawati, Diah Savitri Prahasanti, Chiquita Aljunaid, Mohammed Amelia, Sarah
Published in
Veterinary World
Background and Aim: The use of drugs as a therapy for traumatic ulcers may lead to drug resistance and other side effects. Lactobacillus casei Shirota can affect the number of fibroblasts and blood vessels in wound healing. The aim of this study was to investigate the difference in the number of fibroblast cells and blood vessels after the topical ...
Otake, Sho Otsubaki, Tomoko Uesato, Naofumi Ueda, Yoshifumi Murayama, Toshihiko Hayashi, Mikio
Published in
Biological & pharmaceutical bulletin
Psoriasis is an immune disorder-related inflammatory skin disease. Recent studies have suggested a contribution of T cell activation in the pathogenesis of psoriasis. Interleukin-2 (IL-2)-inducible T cell kinase (ITK) regulates T cell activation, including proliferation, and cytokine production. In this study, we investigated the effect of the topi...
Li, Danhui Martini, Nataly Liu, Mengyang Falconer, James R Locke, Michelle Wu, Zimei Wen, Jingyuan
Published in
Journal of drug targeting
Numerous skin disorders and diseases are related to oxidative stress. The application of an antioxidant, serving as a strong defense agent against oxidation, is of great interest in dermatology yet remains challenging for delivery. This paper aimed to develop a niosome carrier system to deliver the antioxidant (+) Catechin into the skin. (+) Catech...
Jebbawi, Ranime
Psoriasis is a chronic inflammatory skin disease that affects 2-3% of the world's population. It is characterized by an abnormal proliferation of keratinocytes, dilation of dermal blood vessels and an infiltration of inflammatory cells into the skin. Although effective, the side effects of anti-psoriatic treatments limit their long-term use. A Poly...
Takeda, Yohei Jamsransuren, Dulamjav Matsuda, Sachiko Crea, Roberto Ogawa, Haruko
Published in
Viruses
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally. Although measures to control SARS-CoV-2, namely, vaccination, medication, and chemical disinfectants are being investigated, there is an increase in the demand for auxiliary antiviral approaches using natural compounds. Here we have focused on hydroxytyrosol (HT)-...
