mitchell, scott j. phillips, grant d. tench, becks yunkai, li belelli, delia martin, stephen j. swinny, jerome d. kelly, louise atack, john r. paradowski, michael
...
The recent approval of formulations of the endogenous neurosteroid allopregnanolone (brexanolone) and the synthetic neuroactive steroid SAGE-217 (zuranolone) to treat postpartum depression (PPD) has encouraged further research to elucidate why these potent enhancers of GABAAR function are clinically effective in this condition. Dopaminergic project...
Liddiard, G T Suryavanshi, P S Glykys, J
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Approximately one-third of neonatal seizures do not respond to first-line anticonvulsants, including phenobarbital, which enhances phasic inhibition. Whether enhancing tonic inhibition decreases seizure-like activity in the neonate when GABA is mainly depolarizing at this age is unknown. We evaluated if increasing tonic inhibition using THIP [4,5,6...
villalobos, nelson
Network dynamics are crucial for action and sensation. Changes in synaptic physiology lead to the reorganization of local microcircuits. Consequently, the functional state of the network impacts the output signal depending on the firing patterns of its units. Networks exhibit steady states in which neurons show various activities, producing many ne...
Reddy, Doodipala Samba
Published in
Trends in molecular medicine
Postpartum depression (PPD) is associated with a decline in progesterone-derived anxiolytic-antidepressant neurosteroids after delivery. Neurosteroid replacement therapy (NRT) with GABA-A receptor-modulating allopregnanolone (brexanolone) shows promise as the first drug treatment for PPD. Here we describe the molecular insights of the neurosteroid ...
Bogaj, Karolina Kaplon, Roksana Urban-Ciecko, Joanna
Published in
Frontiers in Cellular Neuroscience
Extrasynaptic GABAA receptors (GABAARs) mediating tonic inhibition are thought to play an important role in the regulation of neuronal excitability. However, little is known about a cell type-specific tonic inhibition in molecularly distinctive types of GABAergic interneurons in the mammalian neocortex. Here, we used whole-cell patch-clamp techniqu...
Huang, Tzu-Hsuan Lin, Yi-Sian Hsiao, Chiao-Wan Wang, Liang-Yun Ajibola, Musa Iyiola Abdulmajeed, Wahab Imam Lin, Yu-Ling Li, Yu-Jui Chen, Cho-Yi Lien, Cheng-Chang
...
Published in
Frontiers in Cellular Neuroscience
Inhibitory γ-aminobutyric acid (GABA)-ergic interneurons mediate inhibition in neuronal circuitry and support normal brain function. Consequently, dysregulation of inhibition is implicated in various brain disorders. Parvalbumin (PV) and somatostatin (SST) interneurons, the two major types of GABAergic inhibitory interneurons in the hippocampus, ex...
Wyroślak, Marcin Dobrzański, Grzegorz Mozrzymas, Jerzy W.
Published in
Frontiers in Cellular Neuroscience
GABAA receptors present in extrasynaptic areas mediate tonic inhibition in hippocampal neurons regulating the performance of neural networks. In this study, we investigated the effect of NMDA-induced plasticity on tonic inhibition in somatostatin- and parvalbumin-containing interneurons. Using pharmacological methods and transgenic mice (SST-Cre/PV...
Yang, Junhua Chen, Jianan Liu, Yongqing Chen, Kevin Hong Baraban, Jay M Qiu, Zhaozhu
Published in
Neuron
Addictive drugs increase ventral tegmental area (VTA) dopamine (DA) neuron activity through distinct cellular mechanisms, one of which involves disinhibition of DA neurons by inhibiting local GABA neurons. How drugs regulate VTA GABA neuron activity and drive addictive behaviors remains poorly understood. Here, we show that astrocytes control VTA G...
Sun, Yu Peng, Zechun Wei, Xiaofei Zhang, Nianhui Huang, Christine S Wallner, Martin Mody, Istvan Houser, Carolyn R
Decreased expression of the δ subunit of the GABAA receptor (GABAAR) has been found in the dentate gyrus in several animal models of epilepsy and other disorders with increased excitability and is associated with altered modulation of tonic inhibition in dentate granule cells (GCs). In contrast, other GABAAR subunits, including α4 and γ2 subunits, ...
Paulsen, Riley T Burrell, Brian D
Published in
Frontiers in synaptic neuroscience
Endocannabinoids are lipid neuromodulators that are synthesized on demand and primarily signal in a retrograde manner to elicit depression of excitatory and inhibitory synapses. Despite the considerable interest in their potential analgesic effects, there is evidence that endocannabinoids can have both pro-nociceptive and anti-nociceptive effects. ...
