Makhloufi, Camélia Crescence, Lydie Darbousset, Roxane McKay, Nathalie Massy, Ziad A. Dubois, Christophe Panicot-Dubois, Laurence Burtey, Stéphane Poitevin, Stéphane
Published in
TH Open: Companion Journal to Thrombosis and Haemostasis
The coexistence of bleeding and thrombosis in patients with chronic kidney disease (CKD) is frequent and poorly understood. Mouse models are essential to understand complications of CKD and to develop new therapeutic approaches improving the health of patients. We evaluated the hemostasis in two models of renal insufficiency: adenine-diet and 5/6th...
Centeno, Alberto Rojas, Santiago Arias, Belén Miquel, Ignasi Sánchez, Pilar Ureta, Claudia Rincón, Esther López, Ramón Murat, Jesús
Published in
Journal of investigative surgery : the official journal of the Academy of Surgical Research
Background: Excessive blood loss is a relevant complication of partial liver resection. Topical hemostatic agents have proven useful to improve the control of the bleeding in this among other surgical indications. Until now all of these products have been based on the action of thrombin. In contrast TT-173 is a new topical hemostatic agent based on...
Lano, Guillaume Laforêt, Manon Von Kotze, Clarissa Perrin, Justine Addi, Tawfik Brunet, Philippe Poitevin, Stéphane Burtey, Stéphane Dou, Laetitia
Published in
International Journal of Molecular Sciences
Endogenous agonists of the transcription factor aryl hydrocarbon receptor (AHR) such as the indolic uremic toxin, indoxyl sulfate (IS), accumulate in patients with chronic kidney disease. AHR activation by indolic toxins has prothrombotic effects on the endothelium, especially via tissue factor (TF) induction. In contrast, physiological AHR activat...
Labarrere, Carlos A. Dabiri, Ali E. Kassab, Ghassan S.
Published in
Frontiers in Bioengineering and Biotechnology
Blood-contacting medical devices of different biomaterials are often used to treat various cardiovascular diseases. Thrombus formation is a common cause of failure of cardiovascular devices. Currently, there are no clinically available biomaterials that can totally inhibit thrombosis under the more challenging environments (e.g., low flow in the ve...
Pontarollo, Giulia Mann, Amrit Brandão, Inês Malinarich, Frano Schöpf, Marie Reinhardt, Christoph
Published in
The FEBS journal
Protease-activated receptors (PARs) are a unique class of G-protein-coupled transmembrane receptors, which revolutionized the perception of proteases from degradative enzymes to context-specific signaling factors. Although PARs are traditionally known to affect several vascular responses, recent investigations have started to pinpoint the functiona...
Xia, Qing Zhang, Xu Chen, Qianqian Chen, Xiangyun Teng, Junliang Wang, Changhui Li, Ming Fan, Lihong
Published in
Journal of Cancer
Objective: Tissue factor (TF) is clinically identified as a marker for the detection of various types of cancer as well as the prediction of prognosis for cancer patients. This present study aims to explore the possibility and feasibility to use plasma TF as a biomarker for the prediction of prognosis of patients with non-small cell lung cancer (NS...
Zhang, Chenghui Ou, Qing Gu, Yan Cheng, Gaiping Du, Rong Yuan, Li Cordiner, Ruth LM Kang, Deying Zhang, Jiaying Huang, Qiaorong
...
Published in
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Aim To investigate the count of circulating tissue factor-positive (TF+) procoagulant microparticles (MPs) in patients with type 1 diabetes mellitus (T1DM). Methods This case-control study included patients with T1DM and age and sex-matched healthy volunteers. The counts of phosphatidylserine-positive (PS+) MPs and TF+PS+MPs and the subgroups deriv...
Jesel, Laurence Abbas, Malak Park, Sin-Hee Matsushita, Kensuke Kindo, Michel Hasan, Hira Auger, Cyril Sato, Chisato Ohlmann, Patrick Mazzucotelli, Jean-Philippe
...
Published in
Journal of Clinical Medicine
Background: Whilst the link between aging and thrombogenicity in atrial fibrillation (AF) is well established, the cellular underlying mechanisms are unknown. In AF, the role of senescence in tissue remodeling and prothrombotic state remains unclear. Aims: We investigated the link between AF and senescence by comparing the expression of senescence ...
KOBAYASHI, Kosuke BABA, Kenji IGASE, Masaya MIYAMA, Takako Shimokawa KAMBAYASHI, Satoshi OKUDA, Masaru
Published in
The Journal of Veterinary Medical Science
Microparticle (MP)-associated tissue factor (TF) activity in plasma might play a role in human disseminated intravascular coagulation (DIC). The aim of this study was to compare MP-TF activity between non-DIC and DIC groups. Ten clinically healthy beagles and 26 diseased dogs were enrolled. The proportion of dogs with increased MP-TF activity was s...
Liberale, Luca Holy, Erik W Akhmedov, Alexander Bonetti, Nicole R Nietlispach, Fabian Matter, Christian M Mach, François Montecucco, Fabrizio Beer, Jürg H Paneni, Francesco
...
Published in
Journal of clinical medicine
CANTOS reported reduced secondary atherothrombotic events in patients with residual inflammatory risk treated with the inhibitory anti-IL-1β antibody, Canakinumab. Yet, mechanisms that underlie this benefit remain elusive. Recent work has implicated formation of neutrophil extracellular traps (NETosis) in arterial thrombosis. Hence, the present stu...
