Targeted therapy in advanced thyroid cancer
Published in Frontiers in Endocrinology
Targeted therapy in advanced thyroid cancer
The epidemic of thyroid cancer in China: Current trends and future prediction
Published in Frontiers in Oncology
Background Thyroid cancer (TC) is one of the most common cancers in China. The aim of this study was to identify the potential age, period, and cohort effect under the long-term trends in TC incidence and mortality, making projections up to 2030. Methods Incidence and mortality data on TC were obtained from the Global Burden of Disease Study 2019. ...
Prevention of salivary gland dysfunction in patients treated with radioiodine for differentiated thyroid cancer: A syste...
Published in Frontiers in Endocrinology
Introduction Salivary gland dysfunction (e.g., sialadenitis and xerostomia) is the most common complication of radioactive iodine (RAI) therapy for differentiated thyroid cancer (DTC). Several methods have been used to reduce/prevent this adverse effect. We aimed to systematically review the effectiveness of non-pharmacological and pharmacological ...
Health-related quality of life in long-term differentiated thyroid cancer survivors: A cross-sectional Tunisian-based st...
Published in Frontiers in Endocrinology
Background and Aim The incidence of differentiated thyroid cancer (DTC) has risen dramatically worldwide. Despite an excellent prognosis, the growing DTC survivors’ community often features poor health-related quality of life (HRQoL), which challenges long-term DTC care, particularly in developing Southern Mediterranean and African countries. We ai...
Inflammasome activation as a link between obesity and thyroid disorders: Implications for an integrated clinical managem...
Published in Frontiers in Endocrinology
Obesity is strongly associated with chronic low-grade inflammation. Obese patients have an increased risk to develop thyroid autoimmunity and to became hypothyroid, suggesting a pathogenetic link between obesity, inflammation and autoimmunity. Moreover, type 2 diabetes and dyslipidemia, also characterized by low-grade inflammation, were recently as...
The relationships between the gut microbiota and its metabolites with thyroid diseases
Published in Frontiers in Endocrinology
Emerging studies have provided a preliminary understanding of the thyroid-gut axis, indicating that intestinal microbiota and its metabolites may act directly or indirectly on the thyroid by influencing intestinal microelements uptake, iodothyronine conversion and storage, and immune regulation, providing new insights into the pathogenesis of thyro...
Identification of immune-related ferroptosis prognostic marker and in-depth bioinformatics exploration of multi-omics me...
Published in Frontiers in Molecular Biosciences
Background: Factors such as variations in thyroid carcinoma (THCA) gene characteristics could influence the clinical outcome. Ferroptosis and immunity have been verified to play an essential role in various cancers, and could affect the cancer patients’ prognosis. However, their relationship to the progression and prognosis of many types of THCA re...
Related factor analysis for predicting large-volume central cervical lymph node metastasis in papillary thyroid carcinom...
Published in Frontiers in Endocrinology
The aim of this study was to investigate the factors related to large-volume central cervical lymph node metastasis (LNM) in papillary thyroid carcinoma. A retrospective study of 340 patients with 642 papillary thyroid carcinoma nodules who underwent thyroidectomy in Peking Union Medical College Hospital between 2011 and 2015 was conducted. These n...
Cell non-autonomous effect of hepatic growth differentiation factor 15 on the thyroid gland
...
Published in Frontiers in Endocrinology
The thyroid gland plays an essential role in the regulation of body energy expenditure to maintain metabolic homeostasis. However, to date, there are no studies investigating the morphological and functional changes of the thyroid gland due to mitochondrial stress in metabolic organs such as the liver. We used data from the Genotype-Tissue Expressi...
Bone metastases in newly diagnosed patients with thyroid cancer: A large population-based cohort study
Published in Frontiers in Oncology
Background Population-based estimates of the incidence and prognosis of bone metastases (BM) stratified by histologic subtype at diagnosis of thyroid cancer are limited. Methods Using multivariable logistic and Cox regression analyses, we identified risk factors for BM and investigated the prognostic survival of BM patients between 2010 and 2015 vi...
