Zinatullina, K. M. Orekhova, A. V. Kasaikina, O. T. Khrameeva, N. P. Berezin, M. P. Rusina, I. F.
Published in
Russian Chemical Bulletin
The kinetic characteristics of the interaction of N-acetylcysteine (ASH) with reactive oxygen species (ROS), peroxyl radicals and hydrogen peroxide were determined. It was found that in terms of activity ASH in these reactions is similar to glutathione GSH, the main endogenous bioantioxidant. The kinetics of heat release in the interaction of GSH a...
Zinatullina, K. M. Kasaikina, O. T. Khrameeva, N. P. Indeykina, M. I. Kononikhin, A. S.
Published in
Kinetics and Catalysis
AbstractThe kinetics of interaction between glutathione (GSH) and unsaturated phenol resveratrol (RVT) in deionized water in the presence of hydrogen peroxide (H2O2) is studied. At a physiological concentration (0.1–10 mM), GSH containing two carboxyl groups forms acidic solutions (pH of 3–4); the GSH molecules are associated into dimers. Under the...
Dief, Essam M Darwish, Nadim
Published in
ACS sensors
Herein, we report ultrasonic generation of thiyl radicals as a general method for functionalizing a range of surfaces with organic molecules. The method is simple, rapid, can be utilized at ambient conditions and involves sonicating a solution of disulfide molecules, homolytically cleaving S-S bonds and generating thiyl radicals that react with the...
Zinatullina, K. M. Kasaikina, O. T. Motyakin, M. V. Ionova, I. S. Degtyarev, E. N. Khrameeva, N. P.
Published in
Russian Chemical Bulletin
Using the method of inhibitors it was found that the reduction of H2O2 with natural thiols in aqueous solutions is accompanied by the formation of radicals. The reaction of the nitroxyl radical TEMPO with glutathione (GSH) and H2O2 was studied together and separately. It allowed us to determine the optimal conditions for using the spin trap method ...
Kaczmarek, Renata Ward, Samuel Debnath, Dipra Jacobs, Taisiya Stark, Alexander D Korczyński, Dariusz Kumar, Anil Sevilla, Michael D Denisov, Sergey A Shcherbakov, Viacheslav
...
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
The directionality of the hole-transfer processes between DNA backbone and base was investigated by using phosphorodithioate [P(S- )=S] components. ESR spectroscopy in homogeneous frozen aqueous solutions and pulse radiolysis in aqueous solution at ambient temperature confirmed initial formation of G.+ -P(S- )=S. The ionization potential of G-P(S- ...
Schöneich, Christian
Published in
Molecules (Basel, Switzerland)
Free radical pathways play a major role in the degradation of protein pharmaceuticals. Inspired by biochemical reactions carried out by thiyl radicals in various enzymatic processes, this review focuses on the role of thiyl radicals in pharmaceutical protein degradation through hydrogen atom transfer, electron transfer, and addition reactions. Thes...
Torreggiani, Armida Tinti, Anna Jurasekova, Zuzana Capdevila, Mercè Saracino, Michela Di Foggia, Michele
Published in
Biomolecules
Model systems constituted by proteins and unsaturated lipid vesicles were used to gain more insight into the effects of the propagation of an initial radical damage on protein to the lipid compartment. The latter is based on liposome technology and allows measuring the trans unsaturated fatty acid content as a result of free radical stress on prote...
Breder, Alexander Depken, Christian
Published in
Angewandte Chemie (International ed. in English)
Cooperativity has become a mainstay in the context of multicatalytic reaction design. The combination of two or more catalysts that possess mechanistically distinct activation principles within a single chemical setting can enable bond constructions that would be impossible for any of the catalysts alone. An emerging subdomain within the field of m...
Zinatullina, K. M. Kasaikina, O. T. Kuz’min, V. A. Khrameeva, N. P.
Published in
Kinetics and Catalysis
AbstractThe kinetics of the interaction of glutathione (GSH) with hydrogen peroxide (H2O2) was studied. It was shown that the rate of GSH consumption nonlinearly depended on reactant concentrations and the process was accompanied by the appearance of radicals with a relatively low rate, which was a fraction of a percent of the rate of GSH consumpti...
Padovani, Dominique Hessani, Assia Castillo, Francine T. Liot, Géraldine Andriamihaja, Mireille Lan, Annaïg Pilati, Camilla Blachier, François Sen, Suvajit Galardon, Erwan
...
Published in
Nat Commun
