Mlynarz, Nicola Miedziaszczyk, Miłosz Wieckowska, Barbara Szalek, Edyta Lacka, Katarzyna
Published in
International journal of molecular sciences
Metabolic syndrome (MS) comprises several symptoms or disorders that significantly increase the risk of developing atherosclerosis and type 2 diabetes. This study aims to determine the direct impact of testosterone therapy on the components of MS; although excluding type 2 diabetes cases. The authors conducted a systematic literature search of PubM...
Zitzmann, Michael Cremers, Jann-Frederik Krallmann, Claudia Soave, Armin Kliesch, Sabine
Published in
Andrology
The longitudinal efficacy and clinical utility of Testosterone Therapy (TTh) in ameliorating functional hypogonadism (FH) remain contentious, with long-term data being scarce. To address this lacuna, a comprehensive long-term registry study, stratifying patients across a spectrum of hypogonadal etiologies, offers a robust investigative paradigm. Th...
Ramachandran, Pravinath Zitzmann, Michael König, Carola S. Mulhern, Joseph Ramachandran, Sudarshan Hackett, Geoffrey
Published in
Exploration of Endocrine and Metabolic Diseases
Aim: To evaluate changes in quality of life via the ageing male symptom scale (AMSS) and somatic, psychological, and sexual sub-scales following testosterone undecanoate (TU) or placebo (P) treatment in men with type 2 diabetes mellitus (T2DM) and adult-onset testosterone deficiency (TD) via a re-analysis of the BLAST (Burntwood, Lichfield, Atherst...
Haider, Karim Sultan Zitzmann, Michael Ramachandran, Pravinath König, Carola S Hackett, Geoffrey Haider, Ahmad Saad, Farid Desnerck, Pieter Strange, Richard Mann, Amar
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OBJECTIVE: We evaluated change (Δ) in AMSS in men with adult-onset testosterone deficiency (TD) on/not on testosterone undecanoate (TU) by analysing a registry of men with adult-onset TD. METHODS: Analyses were performed using non-parametric statistics to determine ΔAMSS at 6-12 monthly intervals in men on/not on TU and movement in AMSS. Factors pr...
kaltsas, aris stavropoulos, marios symeonidis, evangelos n. kratiras, zisis zachariou, athanasios zikopoulos, athanasios chrisofos, efthalia emmanouela dimitriadis, fotios sofikitis, nikolaos chrisofos, michael
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Endometriosis is a debilitating gynecological condition commonly seen in individuals designated female at birth; however, there has been limited research focused on its prevalence and impact among transgender men. This narrative review aims to fill a critical knowledge gap by exploring the epidemiology, clinical manifestations, management strategie...
Mann, Amar Strange, Richard C. Hackett, Geoffrey König, Carola Ramachandran, Sudarshan
Published in
Exploration of Endocrine and Metabolic Diseases
Adult-onset testosterone deficiency (TD) in men is diagnosed by the finding of low serum testosterone levels and recognised, associated symptoms. The condition has high prevalence in men over 50 years of age, particularly those with type 2 diabetes (T2DM). Accumulating data show adult-onset TD is associated with increased mortality risk. We review ...
Papeleu, Tine Leyns, Clara Alighieri, Cassandra Vermeeren, Amber Motmans, Joz T'Sjoen, Guy D'haeseleer, Evelien
Objectives/hypotheses: The purpose of this study was to investigate voice and communication difficulties in transmasculine individuals to develop evidence-based voice and communication training programs. Study design: Qualitative study. Methods: Eight transmasculine individuals, who had received testosterone therapy (TT) for at least 1 year, were i...
magnussen, line velling jørgensen, louise helskov glintborg, dorte andersen, marianne skovsager
High hepcidin is linked to low-grade inflammation and lower iron levels. The consequences of testosterone replacement therapy (TRT) on inflammation and the risk of cardiovascular disease (CVD) are undetermined. We investigate the effect of TRT on the inflammatory cardiovascular risk markers hepcidin-iron, fibroblast growth factor 23 (FGF23)-phospha...
Britton, Rhys C Beamish, Nicole F
Published in
Journal of the Endocrine Society
Purpose To summarize the current state of knowledge surrounding the impact of testosterone therapy on cardiovascular risk factors in postmenopausal women. Methodology In this scoping review, a comprehensive search of peer-reviewed literature was conducted in adherence to a methodological framework comprising 4 distinct stages: conceptualizing a com...
Mann, Amar Strange, Richard C König, Carola S Hackett, Geoffrey Haider, Ahmad Haider, Karim Sultan Desnerck, Peter Ramachandran, Sudarshan
Publication status: Published / OBJECTIVES: We describe studies determining the association between testosterone therapy (TTh) and mortality. MATERIALS & METHODS: We used a registry database of 737 men with adult-onset testosterone deficiency defined as presenting with low serum total testosterone (TT) levels ≤12.1 nmol/L and associated symptoms ov...
