Mwende Mutiso, Janet Mayanja, Sarah Nyaga, John Sinelle, Sophie Renou, Camille Onyango, Charles Hareau, Guy Polar, Vivian Ashby, Jacqueline Okello, Julius Juma
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Published in
Frontiers in Sustainable Food Systems
The study assesses the gender implications of a target product profile for table potato in Kenya. Breeding programs mostly emphasize farmers’ trait requirements and rarely pay attention to other value chain actors’ preferences. This partially contributes to the low uptake of improved varieties. Therefore, efforts are required to assess the gender i...
Lu, Katie Brauns, Timothy Sluder, Ann E Poznansky, Mark C Dogan, Fatma
Published in
FASEB bioAdvances
While progress has been made in the development of islet cell transplantation (ICT) as a viable alternative to the use of exogenous insulin therapy in the treatment of type 1 diabetes, it has not yet achieved its full potential in clinical studies. Ideally, ICT would enable lifelong maintenance of euglycemia without the need for exogenous insulin, ...
Caldwell, Nicola Afshar, Rana Baragaña, Beatriz Bustinduy, Amaya L Caffrey, Conor R Collins, James J Fusco, Daniela Garba, Amadou Gardner, Mark Gomes, Mireille
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In September 2022, the Drug Discovery Unit at the University of Dundee, UK, organised an international meeting at the Wellcome Collection in London to explore the current clinical situation and challenges associated with treating schistosomiasis. The aim of this meeting was to discuss the need for new treatments in view of the clinical situation an...
Fongwen, Noah Asiedu, Kingsley B Bakhiet, Sahar Bonifaz, Alexandro Cruz, Israel Argaw, Daniel Estrada-Chavez, Guadalupe Fahal, Ahmed H Litvintseva, Ana Marks, Michael
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Published in
Tropical medicine & international health : TM & IH
Mycetoma is a neglected tropical disease caused by more than 70 different microorganisms and identified by the WHO as one of the high-priority diseases for developing diagnostic tests. To ensure the production of diagnostic assays for use by clinical staff in endemic regions, target product profiles (TPPs) were designed. We describe the development...
Martín-Escolano, Javier Marín, Clotilde Rosales, María J Tsaousis, Anastasios D Medina-Carmona, Encarnación Martín-Escolano, Rubén
Published in
ACS infectious diseases
Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies CD as the most prevalent of poverty-promoting neglected tropical diseases, the most important parasitic one, and the third most infectious disease in Latin America. Current...
d., colin
The coronavirus SARS-CoV-2, which causes Coronavirus disease 2019 (COVID-19), has infected more than 100 million people globally and caused over 2.5 million deaths in just over one year since its discovery in Wuhan, China in December 2019. The pandemic has evoked widespread collateral damage to societies and economies, and has destabilized mental h...
Villamagna, Angela Holly Gore, Sara J. Lewis, James S. Doggett, J. Stone
Published in
Frontiers in Medicine
Respiratory failure due to SARS-CoV-2 has caused widespread mortality, creating an urgent need for effective treatments and a long-term need for antivirals for future emergent coronaviruses. Pharmacotherapy for respiratory viruses has largely been unsuccessful with the exception of early treatment of influenza viruses, which shortens symptom durati...
Timpe, Carsten Stegemann, Sven Barrett, Andrew Mujumdar, Siddharthya
Published in
British journal of clinical pharmacology
In the past, drug developers in industry chose approaches mainly focusing on the drug product's efficacy, safety and quality according to the level required by regulatory expectations stipulated in guidelines, pharmacopoeia and other regulatory provisions. By putting more focus on the patient perspective, regulatory authorities are currently raisin...
Craciunas, Laurentiu Pickering, Oonagh Chu, Justin Žurauskienė, Justina Coomarasamy, Arri
Published in
European journal of obstetrics, gynecology, and reproductive biology
To assess the women's views in relation to the characteristics of an endometrial receptivity test in the context of recurrent miscarriage with an overarching aim to guide the development of a Target Product Profile (TPP) based on minimum acceptable ("worst-case") and ideal ("best-case") features. This was a descriptive cross-sectional study involvi...
Callahan, Rebecca L Mehta, Neha J Nanda, Kavita Kopf, Gregory S
Published in
Biology of reproduction
A significant global unmet need for new contraceptive options for both women and men remains due to side effect profiles, medical concerns, and inconvenience of many currently available products. The pharmaceutical industry has largely abandoned early research and development for contraception and will not likely engage to bring new products to the...
