Proceedings of the National Academy of Sciences of the United States of America
The plant growth hormone auxin controls cell identity, cell division, and expansion. In the primary root of Arabidopsis there is a robust auxin gradient with a peak concentration at the tip of the meristem and a significant decrease throughout the elongation zone. The molecular mechanisms of how such a steep auxin gradient is established and mainta...
Medicina (Kaunas, Lithuania)
Background and objectives: Body mass index (BMI) is commonly used to assess the proportionality of body mass; however, there are currently no standards for assessing the weight status of the child population for the needs of epidemiological studies. This study aims to establish bioelectric impedance analysis (BIA) standards for assessing the body w...
The Target of Rapamycin (TOR) is a highly conserved serine/threonine protein kinase that performs essential roles in the control of cellular growth and metabolism. TOR acts in two distinct multiprotein complexes, TORC1 and TORC2 (mTORC1 and mTORC2 in humans), which maintain different aspects of cellular homeostasis and orchestrate the cellular resp...
The protein kinase TOR is an evolutionary “TORtoise” that has not significantly evolved since the last eukaryotic common ancestor. Here, Brunkard discusses recent studies illuminating how signaling networks upstream and downstream of TOR have evolved through exaptation and adaptation to coordinate metabolism in diverse eukaryotic lineages.
International Journal of Molecular Sciences
Target of rapamycin (TOR) acts as a master regulator in coordination of cell growth with energy and nutrient availability. Despite the increased appreciation of the essential role of the TOR complex in interaction with phytohormone signaling, little is known about its function on ethylene signaling. Here, through expression analysis, genetic and bi...
Frontiers in genetics
DNA methylation is an indispensable epigenetic modification that dynamically regulates gene expression and genome stability during cell growth and development processes. The target of rapamycin (TOR) has emerged as a central regulator to regulate many fundamental cellular metabolic processes from protein synthesis to autophagy in all eukaryotic spe...
BioEssays : news and reviews in molecular, cellular and developmental biology
In response to nutrient limitation, many animals, including Caenorhabditis elegans, slow or arrest their development. This process requires mechanisms that sense essential nutrients and induce appropriate responses. When faced with nutrient limitation, C. elegans can induce both short and long-term survival strategies, including larval arrest, decr...
This study was conducted to explore the regulatory role of the target of rapamycin complex 1 (TORC1) signaling pathway in crop milk synthesis in breeding pigeons (Columba livia). Three groups of breeding pigeons in the lactation period (n = 30 pairs/group) were respectively injected with rapamycin (RAPA, a specific inhibitor of the target of rapamy...
Frontiers in cell and developmental biology
Autophagy is a major cellular recycling process that delivers cellular material and entire organelles to lysosomes for degradation, in a selective or non-selective manner. This process is essential for the maintenance of cellular energy levels, components, and metabolites, as well as the elimination of cellular molecular damage, thereby playing an ...