Kaneko, Yuko Kawahito, Yutaka Kojima, Masayo Nakayama, Takeo Hirata, Shintaro Kishimoto, Mitsumasa Endo, Hirahito Seto, Yohei Ito, Hiromu Nishida, Keiichiro
...
Published in
Modern rheumatology
To evaluate the efficacy and safety of tacrolimus in adult patients with rheumatoid arthritis (RA) by using the GRADE approach. We searched PubMed, Japana Centra Revuo Medicina Web (Ichu-shi web), and the Cochrane Database of Systematic Reviews. Articles fulfilling the predefined inclusion criteria were appraised and used for meta-analysis. The pri...
Paiva, Mayara Rodrigues Brandão Andrade, Gracielle Ferreira Dourado, Lays Fernanda Nunes Castro, Brenda Fernanda Moreira Fialho, Silvia Ligório Sousa, Edésia Martins Barros Silva-Cunha, Armando
Published in
Journal of biomaterials applications
Tacrolimus (TAC), a potent immunosuppressive macrolide, has been investigated for ocular diseases due to promising results in the treatment of anterior and posterior segments eye diseases. Mesoporous and functionalized silica nanoparticles show potential as TAC delivery platforms owing to their interesting characteristic as large surface area, unif...
Poshekhontseva, V. Yu. Fokina, V. V. Sukhodolskaya, G. V. Shutov, A. A. Donova, M. V.
Published in
Applied Biochemistry and Microbiology
AbstractThe effect of inactivated yeast cells, individual components of the yeast cells, and the inactivated biomass of filamentous fungi (micromycetes) of various taxonomic positions on the biosynthesis of immunosuppressant tacrolimus (FK-506) by Streptomyces tsukubensis VKM Ac-2618D cells has been studied. The fractions of soluble and insoluble c...
Reynolds, Kelly A Pithadia, Deeti J Lee, Erica B Wu, Jashin J
Published in
The Journal of dermatological treatment
Background: Inverse psoriasis often requires a targeted treatment strategy due to the inherent sensitivity, thinness, and occlusion of flexural areas. However, most treatment recommendations are based on anecdotal evidence.Methods: A systematic literature search was conducted in October 2018 in Pubmed, Scopus, Embase, and Cochrane Library with keyw...
Chin, Ho Jun Chae, Dong-Wan Kim, Yong Chul An, Won Suk Ihm, ChunGyoo Jin, Dong-Chan Kim, Sung Gyun Kim, Yong-Lim Kim, Yong-Soo Kim, Yoon-Goo
...
Published in
Journal of the American Society of Nephrology : JASN
Tacrolimus is used as a steroid-sparing immunosuppressant in adults with minimal change nephrotic syndrome. However, combined treatment with tacrolimus and low-dose steroid has not been compared with high-dose steroid for induction of clinical remission in a large-scale randomized study. In this 24-week open-label noninferiority study, we randomize...
Fernández-Juárez, Gema Rojas-Rivera, Jorge Logt, Anne-Els van de Justino, Joana Sevillano, Angel Caravaca-Fontán, Fernando Ávila, Ana Rabasco, Cristina Cabello, Virginia Varela, Alfonso
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Published in
Kidney international
A cyclical corticosteroid-cyclophosphamide regimen is recommended for patients with primary membranous nephropathy at high risk of progression. We hypothesized that sequential therapy with tacrolimus and rituximab is superior to cyclical alternating treatment with corticosteroids and cyclophosphamide in inducing persistent remission in these patien...
Nakagawa, Koji Funaki, Satoru Hisano, Michi Sugiyama, Rikikazu Yamaguchi, Koushi
Published in
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
A Rho-incompatible pregnancy induces anemia in the fetus and can ultimately lead to fetal hydrops and intrauterine fetal death. A patient who had experienced recurrent implantation failures following a first successful delivery finally succeeded in achieving a second pregnancy via the use of tacrolimus. The second pregnancy was Rho-incompatible. Du...
Salionov, D. S. Poshekhontseva, V. Yu. Fokina, V. V. Shutov, A. A. Nikolaeva, V. M. Vasiarov, G. G. Titova, E. V. Karasev, V. S. Staroverov, S. M. Donova, M. V.
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Published in
Applied Biochemistry and Microbiology
AbstractTacrolimus is known as the most effective immunosuppressive drug which is synthesized by actinobacteria of the genus Streptomyces. Its biosynthesis is accompanied by the formation of the structural analogs. A new method for the production of tacrolimus by Streptomyces tsukubensis BKM Ac-2618D with the use of brominated styrene-divinylbenzen...
Zimecki, Michał Artym, Jolanta Kałas, Wojciech Strządała, Leon Kaleta-Kuratewicz, Katarzyna Kuryszko, Jan Kaszuba, Andrzej Kaczmarek, Krzysztof Zabrocki, Janusz
Published in
Pharmaceutics
A cyclic tetrapeptide Pro-Pro-Pheβ3ho-Phe (4B8M) was tested for immunosuppressive activity and potential therapeutic utility in several in vitro and in vivo mouse and human models. The tetrapeptide was less toxic for mouse splenocytes in comparison to cyclosporine A (CsA) and a parent cyclolinopeptide (CLA). The tetrapeptide demonstrated potent ant...
Bertrand, Dominique Terrec, Florian Etienne, Isabelle Chavarot, Nathalie Sberro, Rebecca Gatault, Philippe Garrouste, Cyril Bouvier, Nicolas Grall-Jezequel, Anne Jaureguy, Maïté
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Published in
Journal of Clinical Medicine
Conversion from calcineurin-inhibitors (CNIs) to belatacept can help kidney-transplant (KT) recipients avoid CNI-related nephrotoxicity. The risk of associated opportunistic infections (OPIs) is ill-defined. We conducted a multicentric cohort study across 15 French KT-centers in a real-life setting. Between 07-2010 and 07-2019, 453 KT recipients we...
