Sivapalan, Pradeesh Bikov, András Jensen, Jens-Ulrik
Published in
Diagnostics (Basel, Switzerland)
Treating patients hospitalised with acute exacerbations of chronic obstructive pulmonary disease (COPD) usually involves administering systemic corticosteroids. The many unwanted side effects associated with this treatment have led to increased interest in minimising the accumulated corticosteroid dose necessary to treat exacerbations. Studies have...
Sullivan, Patrick W Ghushchyan, Vahram H Skoner, David P LeCocq, Jason Park, Siyeon Zeiger, Robert S
Published in
The journal of allergy and clinical immunology. In practice
Limited comparative data are available on impact of systemic corticosteroid (SCS) use in children and adolescents. To determine if asthmatic children and adolescents treated with SCS have a higher likelihood of developing complications versus those not receiving SCS and to examine healthcare resource utilization (HCRU) in this population. A retrosp...
Wu, Jianfeng Huang, Jianqiang Zhu, Guochao Liu, Yihao Xiao, Han Zhou, Qian Si, Xiang Yi, Hui Wang, Cuiping Yang, Daya
...
Published in
The Journal of clinical endocrinology and metabolism
Systemic corticosteroids are now recommended in many treatment guidelines, although supporting evidence is limited to 1 randomized controlled clinical trial (RECOVERY). To identify whether corticosteroids were beneficial to COVID-19 patients. A total of 1514 severe and 249 critical hospitalized COVID-19 patients from 2 medical centers in Wuhan, Chi...
Chauvet, Paul Mallat, Jihad Arumadura, Clothilde Vangrunderbeek, Nicolas Dupre, Céline Pauquet, Philippe Orfi, Annis Granier, Maxime Lemyze, Malcolm
Published in
Critical Care Explorations
Severe coronavirus disease 2019 pneumonia can lead to acute respiratory distress syndrome. Recently, several publications reported on coronavirus disease 2019-associated pulmonary aspergillosis. However, risk factors remain unclear. We retrospectively collected all the cases of coronavirus disease 2019 acute respiratory distress syndrome patients (...
Ricardo, Jose W Lipner, Shari R
Published in
Dermatologic therapy
Sawanyawisuth, Kanlayanee Chattakul, Paiboon Khamsai, Sittichai Boonsawat, Watchara Ladla, Arinrada Chotmongkol, Verajit Limpawattana, Panita Chindaprasirt, Jarin Senthong, Vichai Phitsanuwong, Chalongchai
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Published in
Journal of Emergencies, Trauma, and Shock
Background: Several studies showed that inhaled corticosteroids (ICS) may be a potential treatment in acute asthma exacerbation in children. This study was an update meta-analysis on the roles of ICS in the management of acute asthma exacerbation in children presenting to the hospital. Materials and Methods: Published articles with key words of ICS...
Gu, Yong-Li Pang, Jie Sun, Zeng-Xian Hu, Jing Sun, Ying Wu, Xiao-Wen Guo, Jin-Juan Yang, Guang-Sheng
Published in
Journal of clinical pharmacy and therapeutics
Corticosteroids are recommended by almost all international guidelines for the management of exacerbations of chronic obstructive pulmonary disease (COPD). Nevertheless, due to their side effects, there are still concerns regarding the use of systemic corticosteroids (SCs). The Global Initiative for Chronic Obstructive Lung Disease guideline states...
Humbert, Marc Bourdin, Arnaud Papadopoulos, Nikolaos G Holgate, Stephen T Hanania, Nicola A Halpin, David M G Chapman, Kenneth R Gavornikova, Marcela Price, David B Kaplan, Alan
...
Published in
The Journal of asthma : official journal of the Association for the Care of Asthma
Since their introduction many decades ago, systemic corticosteroids have become a mainstay treatment for asthma. Despite being a highly effective therapy, corticosteroids can cause significant adverse effects in patients. This results in a "double hit" for some patients as they suffer the burden of disease as well as the burden of treatment-induced...
Hillas, Georgios Fouka, Evangelia Papaioannou, Andriana I
Published in
Expert review of respiratory medicine
Introduction: Since the discovery of eosinophils in the sputum of asthmatic patients, several studies have offered evidence on their prominent role in the pathology and severity of asthma. Blood eosinophils, are a useful biomarker for therapy selection in severe asthma patients. IL-5 plays crucial role on maturation, activation, recruitment, and su...
Bleecker, Eugene R Menzies-Gow, Andrew N Price, David B Bourdin, Arnaud Sweet, Stephen Martin, Amber L Alacqua, Marianna Tran, Trung N
Published in
American journal of respiratory and critical care medicine
Systemic corticosteroid use to manage uncontrolled asthma and its associated healthcare burden may account for important health-related adverse effects. We conducted a systematic literature review to investigate the real-world extent and burden of systemic corticosteroid use in asthma. We searched MEDLINE and Embase databases to identify English-la...
