Chojnacka, Magdalena Beroun, Anna Magnowska, Marta Stawikowska, Aleksandra Cysewski, Dominik Milek, Jacek Dziembowska, Magdalena Kuzniewska, Bozena
Published in
Frontiers in Molecular Neuroscience
Fragile X syndrome (FXS) is the most common monogenetic cause of inherited intellectual disability and autism in humans. One of the well-characterized molecular phenotypes of Fmr1 KO mice, a model of FXS, is increased translation of synaptic proteins. Although this upregulation stabilizes in adulthood, abnormalities during the critical period of pl...
Zhao, Huilin Yang, Sungchil Fung, Chi Chung Alan
Published in
Frontiers in Computational Neuroscience
Introduction The N-methyl-D-aspartate receptor (NMDAR) plays a critical role in synaptic transmission and is associated with various neurological and psychiatric disorders. Recently, a novel form of postsynaptic plasticity known as NMDAR-based short-term postsynaptic plasticity (STPP) has been identified. It has been suggested that long-lasting glu...
Wang, Wei Sheng Shi, Zhi Wen Chen, Xin Li Li, Yan Xiao, Hui Zeng, Yu Heng Pi, Xiao Dong Zhu, Li Qiang
Published in
ACS applied materials & interfaces
Brain-inspired neuromorphic computing and portable intelligent electronic products have received increasing attention. In the present work, nanocellulose-gated indium tin oxide neuromorphic transistors are fabricated. The device exhibits good electrical performance. Short-term synaptic plasticities were mimicked, including excitatory postsynaptic c...
Sehgal, Megha Ehlers, Vanessa E. Moyer, James R. Jr.
Published in
Frontiers in Cellular Neuroscience
Introduction New learning results in modulation of intrinsic plasticity in the underlying brain regions. Such changes in intrinsic plasticity can influence allocation and encoding of future memories such that new memories encoded during the period of enhanced excitability are linked to the original memory. The temporal window during which the two m...
Liang, Rong Wang, Ling Yang, Qing Xu, Qing Sun, Shufan Zhou, Haichen Zhao, Meiling Gao, Jing Zheng, Chenguang Yang, Jiajia
...
Published in
Frontiers in Cellular Neuroscience
Introduction The investigation of cognitive function in microgravity, both short-term and long-term, remains largely descriptive. And the underlying mechanisms of the changes over time remain unclear. Methods Behavioral tests, electrophysiological recording, and RNA sequencing were used to observe differences in behavior, synaptic plasticity, and g...
Arshavsky, Yuri I
Published in
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
According to the commonly accepted opinion, memory engrams are formed and stored at the level of neural networks due to a change in the strength of synaptic connections between neurons. This hypothesis of synaptic plasticity (HSP), formulated by Donald Hebb in the 1940s, continues to dominate the directions of experimental studies and the interpret...
Argunsah, Ali Özgür Israely, Inbal
Published in
Frontiers in Cellular Neuroscience
Dendritic spines are highly dynamic structures whose structural and functional fluctuations depend on multiple factors. Changes in synaptic strength are not limited to synapses directly involved in specific activity patterns. Unstimulated clusters of neighboring spines in and around the site of stimulation can also undergo alterations in strength. ...
Lombardi, Aniello Wang, Qiang Stüttgen, Maik C. Mittmann, Thomas Luhmann, Heiko J. Kilb, Werner
Published in
Frontiers in Cellular Neuroscience
Introduction Short-term synaptic plasticity (STP) is a widespread mechanism underlying activity-dependent modifications of cortical networks. Methods To investigate how STP influences excitatory and inhibitory synapses in layer 2/3 of mouse barrel cortex, we combined whole-cell patch-clamp recordings from visually identified pyramidal neurons (PyrN...
Lamanna, Jacopo Ferro, Mattia Cocucci, Emanuele
Published in
Frontiers in Cellular Neuroscience
Kramer, Richard H.
Rod and cone photoreceptors degenerate in retinitis pigmentosa and age-related macular degeneration, robbing the visual system of light-triggered signals necessary for sight. However, changes in the retina do not stop with the photoreceptors. A stereotypical set of morphological and physiological changes, known as remodeling, occur in downstream re...
