Dong, Jing Fu, Hui Fu, Yuanyuan You, Mingdan Li, Xudong Wang, Chaonan Leng, Kunkun Wang, Yuan Chen, Jie
Published in
ACS chemical neuroscience
Exposure to di-(2-ethylhexyl) phthalate (DEHP), a widely used kind of plasticizer, can result in neurodevelopment impairments and learning and memory disorders. We studied the effects and possible mechanisms of maternal DEHP treatment on hippocampal synaptic plasticity in offspring. Pregnant Wistar rats were randomly divided into four groups and re...
Lonnemann, Niklas Hosseini, Shirin Marchetti, Carlo Skouras, Damaris B Stefanoni, Davide D'Alessandro, Angelo Dinarello, Charles A Korte, Martin
Published in
Proceedings of the National Academy of Sciences of the United States of America
Numerous studies demonstrate that neuroinflammation is a key player in the progression of Alzheimer's disease (AD). Interleukin (IL)-1β is a main inducer of inflammation and therefore a prime target for therapeutic options. The inactive IL-1β precursor requires processing by the the nucleotide-binding oligomerization domain-like receptor family, py...
Qu, Wenhui Li, Ling
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Triggering receptor expressed on myeloid cells 2 (TREM2), a receptor exclusively expressed by microglia in the brain, modulates microglial immune homeostasis. Human genetic studies have shown that the loss-of-function mutations in TREM2 signaling are strongly associated with an elevated risk of age-related neurodegenerative diseases including Alzhe...
Agnes, Everton J Luppi, Andrea I Vogels, Tim P
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cortical areas comprise multiple types of inhibitory interneurons, with stereotypical connectivity motifs that may follow specific plasticity rules. Yet, their combined effect on postsynaptic dynamics has been largely unexplored. Here, we analyze the response of a single postsynaptic model neuron receiving tuned excitatory connections alongside inh...
Gendelis, Shani Inbar, Dorrit Inbar, Kineret Mesner, Shanee Kupchik, Yonatan M
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
A major driver of obesity is the increasing palatability of processed foods. Although reward circuits promote the consumption of palatable food, their involvement in obesity remains unclear. The ventral pallidum (VP) is a key hub in the reward system that encodes the hedonic aspects of palatable food consumption and participates in various proposed...
Inglebert, Yanis Aljadeff, Johnatan Brunel, Nicolas Debanne, Dominique
Like many forms of long-term synaptic plasticity, spike-timing-dependent plasticity (STDP) depends on intracellular Ca 2+ signaling for its induction. Yet, all in vitro studies devoted to STDP used abnormally high external Ca 2+ concentration. We measured STDP at the CA3-CA1 hippocampal synapses under different extracellular Ca 2+ concentrations an...
Ostrovskaya, Olga I Cao, Guan Eroglu, Cagla Harris, Kristen M
Published in
Hippocampus
Analysis of long-term potentiation (LTP) provides a powerful window into cellular mechanisms of learning and memory. Prior work shows late LTP (L-LTP), lasting >3 hr, occurs abruptly at postnatal day 12 (P12) in the stratum radiatum of rat hippocampal area CA1. The goal here was to determine the developmental profile of synaptic plasticity leading ...
Ploux, Eva Bouet, Valentine Radzishevsky, Inna Wolosker, Herman Freret, Thomas Billard, Jean-Marie
d-serine is the major co-agonist of N-methyl-D-aspartate receptors (NMDAR) at CA3/CA1 hippocampal synapses, the activation of which drives long-term potentiation (LTP). The use of mice with targeted deletion of the serine racemase (SR) enzyme has been an important tool to uncover the physiological and pathological roles of D-serine. To date, some u...
Cho, In Ha Panzera, Lauren C Chin, Morven Alpizar, Scott A Olveda, Genaro E Hill, Robert A Hoppa, Michael B
Published in
Proceedings of the National Academy of Sciences of the United States of America
Analysis of the presynaptic action potential's (APsyn) role in synaptic facilitation in hippocampal pyramidal neurons has been difficult due to size limitations of axons. We overcame these size barriers by combining high-resolution optical recordings of membrane potential, exocytosis, and Ca2+ in cultured hippocampal neurons. These recordings revea...
Squires, Katherine E Gerber, Kyle J Tillman, Matthew C Lustberg, Daniel J Montañez-Miranda, Carolina Zhao, Meilan Ramineni, Suneela Scharer, Christopher D Saha, Ramendra N Shu, Feng-Jue
...
Published in
The Journal of biological chemistry
The human genome contains vast genetic diversity as naturally occurring coding variants, yet the impact of these variants on protein function and physiology is poorly understood. RGS14 is a multifunctional signaling protein that suppresses synaptic plasticity in dendritic spines of hippocampal neurons. RGS14 also is a nucleocytoplasmic shuttling pr...
