Pal, Arindam Gautam, Anirudh Munjal, Sagar
Published in
Journal of clinical pharmacology
This 3-way, single-dose, randomized crossover study evaluated the pharmacokinetics (PK) and dose proportionality of 5-, 10-, and 15-mg doses of intranasal sumatriptan (DFN-02) coformulated with a permeation enhancer (DDM) in 18 healthy adults. The objective was to determine which DFN-02 dose approximates the PK of a 6-mg dose of sumatriptan deliver...
Ibrahimi, K Danser, Ahj Terwindt, G M van den Meiracker, A H MaassenVanDenBrink, A
Published in
Cephalalgia : an international journal of headache
Current antimigraine drugs are believed, besides their direct vasoconstrictive effect, to inhibit calcitonin gene-related peptide (CGRP) release from trigeminal nerve endings during migraine. Objective The objective of this report is to establish a biomarker for the CGRP-interfering effect of antimigraine drugs. Methods We quantified the effect of ...
Gutman, Dikla Hellriegel, Edward Aycardi, Ernesto Bigal, Marcelo E Kunta, Jeevan Chitra, Rohini Kansagra, Sujay Kidron, Orna Srur Knebel, Helena Linder, Steven
...
Published in
Headache
The iontophoretic TDS produced mean systemic exposures to sumatriptan in younger and older adolescents, in line with what was seen in adult subjects. It was generally well tolerated.
Zheng, Bing Li, Minyan Gao, Gui He, Yuying Walsh, Patrick J
Published in
Advanced synthesis & catalysis
A Palladium-catalyzed α-arylation of sulfonamides with aryl chlorides is presented. A Buchwald type precatalyst formed with Kwong's indole-based ligand enabled this transformation to be compatible with a large variety of methyl sulfonamides and aryl chlorides in good to excellent yields. Importantly, under the optimized reaction conditions, only mo...
Burgos-Vega, Carolina C Ahn, David Dong-Uk Bischoff, Christina Wang, Weiya Horne, Dan Wang, Judy Gavva, Narender Dussor, Gregory
Published in
Cephalalgia : an international journal of headache
These data indicate that transient receptor potential channel M8 activation in the meninges produces behaviors in rats that are consistent with migraine and that are sensitive to pharmacological mechanisms known to have efficacy for migraine in humans. The findings suggest that activation of meningeal transient receptor potential channel M8 may con...
Bigal, Marcelo E Lipton, Richard B Newman, Lawrence C Pierce, Mark W Silberstein, Stephen D
Published in
Headache
Sumatriptan TDS is not associated with the emergence of nausea in migraineurs without nausea. It is equally effective in participants with or without nausea at the time of treatment.
Vikelis, Michail Spingos, Konstantinos C Rapoport, Alan M
Published in
Therapeutic advances in neurological disorders
An iontophoretic transdermal system (ITS) (skin patch) formulation of sumatriptan for the acute treatment of migraine attacks was approved by the US Food and Drug Administration in January 2013. This transdermal system bypasses the gastrointestinal tract, as it uses low electrical current to move sumatriptan transdermally into the subcutaneous tiss...
Labruijere, Sieneke Chan, Kayi Y de Vries, René van den Bogaerdt, Antoon J Dirven, Clemens M Danser, Ah Jan Kori, Shashidhar H MaassenVanDenBrink, Antoinette
Published in
Cephalalgia : an international journal of headache
Contractions to DHE in distal coronary arteries are smaller than those to sumatriptan, while at clinical concentrations they both induce only slight contractions. In meningeal arteries contractions to DHE and sumatriptan are significantly larger, showing their cranioselectivity. Contractions to DHE in the saphenous vein are higher than those in the...
Johnson, Adriana Bickel, Jonathan Lebel, Alyssa
Published in
Pediatric neurology
Our findings support recent data regarding choices of medication in the pediatric population and additionally support current studies and future investigation into controlled trials in the pediatric population.
Calhoun, Anne H Pruitt, Amy P
Published in
Headache
Adult CVS is not only highly comorbid with migraine, but it responds to migraine preventives, and in some cases to injectable sumatriptan even in the absence of headache.
