Rinker, Franziska Bremer, Corinna M Schröder, Kathrin Wiegand, Steffen B Bremer, Birgit Manns, Michael P Kraft, Anke R Wedemeyer, Heiner Yang, Lei Pavlovic, Vedran
...
Published in
Liver international : official journal of the International Association for the Study of the Liver
Hepatitis B virus (HBV) contains three viral surface proteins, large, middle and small hepatitis B surface protein (LHBs, MHBs, SHBs). Proportions of LHBs and MHBs are lower in patients with inactive versus active chronic infection. Interferon alfa may convert HBeAg-positive chronic hepatitis B (CHB) to an inactive carrier state, but prediction of ...
eskelin, katri poranen, minna m.
Viruses protect their genomes by enclosing them into protein capsids that sometimes contain lipid bilayers that either reside above or below the protein layer. Controlled dissociation of virions provides important information on virion composition, interactions, and stoichiometry of virion components, as well as their possible role in virus life cy...
Rausch, Andreas Schanze, Thomas
Published in
Current Directions in Biomedical Engineering
The development of new medicines against virus infections like the Marburg virus disease requires an accurate knowledge of the respective pathogens. Conventionally, this process is very time expensive. In cooperation with the Virology of the Philipps-University in Marburg an automatic tracking algorithm for subviral particles in fluorescence image ...
Kaak, Michelle Rausch, Andreas Müller, Dennis Schanze, Thomas
Published in
Current Directions in Biomedical Engineering
The development of a drug against pathogens of hemorrhagic fever, like the Marburg virus, is a great challenge. Therefore, accurate knowledge of the properties of subviral particles in the host cell must be obtained. The base for subviral particle analysis is a special fluorescence microscopy technique. In order to automate and visualize the subvir...
Rausch, Andreas Schanze, Thomas
Published in
Current Directions in Biomedical Engineering
Automatic detection and tracking of subviral particles in image sequences is an indispensable supportive method for modern medicine research programs. This paper describes the development of a highly adaptable camera-to-world system motion invariant tracking algorithm. A translation compensation is obtained by cross correlations. Particles are dete...
Rausch, Andreas Müller, Dennis Schanze, Thomas
Published in
Current Directions in Biomedical Engineering
Automated detection and tracking of subviral particles is a promising method to obtain insights in complicated virus-cell interactions. This paper describes the implementation of a linear assignment problem solver and a Kalman-filter in an existing particle tracking algorithm. Two different simulated image sequences are used for the evaluation of t...
Roingeard, Philippe
Published in
Liver international : official journal of the International Association for the Study of the Liver
Pijlman, G.P.
Arthropod-borne arboviruses form a continuous threat to human and animal health, but few arboviral vaccines are currently available. Advances in expression technology for complex, enveloped virus-like particles (eVLPs) create new opportunities to develop potent vaccines against pathogenic arboviruses. In this short review, I highlight the successes...
hütter, sylvia zurnic, irena lindemann, dirk
Like all other viruses, a successful egress of functional particles from infected cells is a prerequisite for foamy virus (FV) spread within the host. The budding process of FVs involves steps, which are shared by other retroviruses, such as interaction of the capsid protein with components of cellular vacuolar protein sorting (Vps) machinery via l...
Patient, Romuald Hourioux, Christophe Roingeard, Philippe
Published in
Cellular microbiology
After cell hijacking and intracellular amplification, non-lytic enveloped viruses are usually released from the infected cell by budding across internal membranes or through the plasma membrane. The enveloped human hepatitis B virus (HBV) is an example of virus using an intracellular compartment to form new virions. Four decades after its discovery...
