Published in Frontiers in Molecular Biosciences
Proteostasis mechanisms significantly contribute to the sculpting of the proteomes of all living organisms. ClpXP is a central AAA+ chaperone-protease complex present in both prokaryotes and eukaryotes that facilitates the unfolding and subsequent degradation of target substrates. ClpX is a hexameric unfoldase ATPase, while ClpP is a tetradecameric...
Published in Frontiers in Cell and Developmental Biology
How eukaryotic cells control their duplication is a fascinating example of how a biological system self-organizes specific activities to temporally order cellular events. During cell cycle progression, the cellular level of CDK (Cyclin-Dependent Kinase) activity temporally orders the different cell cycle phases, ensuring that DNA replication occurs...
Published in Exploration of Digestive Diseases
Caspases are key factors in the regulation of the apoptotic and/or inflammatory responses, both crucial in the pathogenesis of diverse diseases. Caspase-2 is the most evolutionary conserved albeit functionally poorly defined member of the caspase family. The precise role of caspase-2 as an initiator or effector caspase is still unknown, but it has ...
Published in Journal of Physics D: Applied Physics
Heavily Sn-doped films of α-Ga2O3 were grown by halide vapor phase epitaxy (HVPE) on basal plane c-sapphire and on (10-12) r-sapphire substrates with and without α-Cr2O3 thin buffers prepared by magnetron sputtering and annealing in air at 500 °C for 3 h. For both substrate orientations, the use of α-Cr2O3 buffers led to three major effects. The fi...
Published in Frontiers in Veterinary Science
Agility is a rapidly growing canine performance sport worldwide, yet the literature is sparse regarding the impact of ground substrate on performance and injury. Approximately 1/3 of dogs participating in agility trials will experience a performance-related injury. The impact of ground material has been well-documented in racing greyhounds, equine ...
Published in Frontiers in Built Environment
Green roofs are becoming increasingly popular in urban construction due to their wide array of benefits for creating a sustainable ecosystem. Many stakeholders invest in green roofs in the 21st century to enhance the environmental quality and mitigate urban ecological pollution. The substrate layer is the most important and critical component of gr...
Published in The FEBS journal
Transglutaminases are protein cross-linking and protein-modifying enzymes that have attracted considerable interest due to their causal involvement in various diseases and versatility in industrial applications. In particular, microbial transglutaminases (MTG) from Streptomyces bacteria have managed in recent years to evolve from simple food additi...
Published in Antimicrobial Agents and Chemotherapy
Albendazole (ABZ) is an anthelmintic with a broad-spectrum activity, widely used in human and veterinary medicine. ABZ is metabolized in all mammalian species to albendazole sulfoxide (ABZSO), albendazole sulfone (ABZSO2) and albendazole 2-aminosulphone (ABZSO2-NH2). ABZSO and ABZSO2 are the main metabolites detected in plasma and all three are det...
Published in Frontiers in Pharmacology
Cytochrome P450 (CYP) 3A7 is one of the major xenobiotic metabolizing enzymes in human embryonic, fetal, and newborn liver. CYP3A7 expression has also been observed in a subset of the adult population, including pregnant women, as well as in various cancer patients. The characterization of CYP3A7 is not as extensive as other CYPs, and health author...
Published in IOP Conference Series: Earth and Environmental Science
Intensification of aquaculture is directed at the effort to increase productivity by carrying capacity of production factors. This study was conducted to evaluate the growth performance of Holothuria scabra cultured intensively through the application of compost fertilizer. H. scabra were reared for 90 days (20 individuals/m2 of density), using a p...
