There is an increasing interest in biodegradable metal implants made from magnesium (Mg), iron (Fe), zinc (Zn) and their alloys because they are well tolerated in vivo and have mechanical properties that approach those of non-degradable metals. In particular, Zn and its alloys show the potential to be the next generation of biodegradable materials ...
Published in Pharmacological Reports
BackgroundThe unpredictable side effects of a majority currently used drugs are the substantial issue, in which patients and physicians are forced to deal with. Augmenting the therapeutic efficacy of drugs may prove more fruitful than searching for the new ones. Since recent studies show that new cationic derivatives of polyisoprenoid alcohols (APr...
Published in Progress in neuro-psychopharmacology & biological psychiatry
This preclinical study investigated how a short-term risperidone treatment in adolescence impacts antipsychotic response to olanzapine and clozapine in adulthood. Antipsychotic effect was indexed by a drug's suppressive effect on avoidance responding in a rat conditioned avoidance response (CAR) model. Male adolescent Sprague-Dawley rats were first...
Published in Reproductive Toxicology
Our aims were to evaluate whether exposure to Bisphenol A (BPA) modifies the development of the male rat mammary gland (MG) and to evaluate whether this modification is gender specific. From gestational day 9, pregnant rats were exposed either subcutaneously to 0, 25 or 250μg BPA/kgbw/day until parturition or orally to 0 and 64μg BPA/kgbw/day until...
Published in Hearing Research
•Cochlear implantation via the round window membrane (RWM) or a cochleostomy.•Sealing material: no additional sealing, muscle graft or carboxylate cement.•Hearing thresholds correlated with the amount of tissue formation.•The RWM approach resulted in less tissue formation than the cochleostomy approach.•Carboxylate cement sealing resulted in a stro...
Published in Pharmacology, biochemistry, and behavior
We aimed to determine the potential of various doses of metoclopramide (MCP, a dopamine antagonist) to reduce lithium chloride (LiCl)-induced conditioned gaping (a nausea-induced behaviour) in rats, using the taste reactivity test. We then evaluated whether an ineffective low dose of cannabidiolic acid (CBDA, 0.1 μg/kg, Rock and Parker, 2013), the ...
Published in Immunobiology
The methylmalonic acidemia is an inborn error of metabolism (IEM) characterized by methylmalonic acid (MMA) accumulation in body fluids and tissues, causing neurological dysfunction, mitochondrial failure and oxidative stress. Although neurological evidence demonstrate that infection and/or inflammation mediators facilitate metabolic crises in pati...
Published in Epilepsy & Behavior
•Melatonin attenuated seizure activity in kainic acid-treated spontaneously hypertensive rats.•Melatonin reduced the neuronal damage in the CA1 area of the hippocampus and piriform cortex.•Melatonin was unable to affect epilepsy-related disturbed diurnal rhythms and behavioral changes.•Behavioral hyperactivity was affected by melatonin treatment af...
Published in Comprehensive Toxicology
Cytotoxic T lymphocytes (CTLs) represent one of several types of cells of the immune system that have the capacity to directly kill other cells. They play a major role in host defense against viral infection, as well as infection by other intracellular pathogens that replicate in the cytoplasm of the host cell. Clinically important infections in wh...
Published in Biochemical and Biophysical Research Communications
The role of MT2-MMP in cancer progression remains to be elucidated in spite of many reports on MT1-MMP. Using a human fibrosarcoma cell, HT1080 and a human gastric cancer cell, TMK-1, endogenous expression of MT1-MMP or MT2-MMP was suppressed by siRNA induction to examine the influence of cancer progression in vitro and in vivo. In HT1080 cells, po...
