Tang, Longteng Zhang, Shuce Zhao, Yufeng Rozanov, Nikita D. Zhu, Liangdong Wu, Jiahui Campbell, Robert E. Fang, Chong
Published in
International Journal of Molecular Sciences
Ratiometric indicators with long emission wavelengths are highly preferred in modern bioimaging and life sciences. Herein, we elucidated the working mechanism of a standalone red fluorescent protein (FP)-based Ca2+ biosensor, REX-GECO1, using a series of spectroscopic and computational methods. Upon 480 nm photoexcitation, the Ca2+-free biosensor c...
Helbing, Tim Carraro, Caterina Francke, Alexander Sosic, Alice De Franco, Michele Gandin, Valentina Göttlich, Richard Gatto, Barbara
Published in
ChemMedChem
In this study, we describe the synthesis and biological evaluation of a set of bis-3-chloropiperidines (B-CePs) containing rigid aromatic linker structures. A modification of the synthetic strategy also enabled the synthesis of a pilot tris-3-chloropiperidine (Tri-CeP) bearing three reactive meta-chloropiperidine moieties on the aromatic scaffold. ...
Hessels, Joeri Masferrer‐Rius, Eduard Yu, Fengshou Detz, Remko J. Klein Gebbink, Robertus J. M. Reek, Joost N. H.
Published in
Chemsuschem
The odd one out : Trends in oxygen evolution activity of nickel complexes are revealed using Oxone as chemical oxidant, showing that there are different design rules for these nickel complexes than for other first‐row transition metals. A cyclam‐like complex with imine donor groups is most active, reaching a turnover number of up to 380 and a turno...
Seifert, Markus Marschall, Mathias S. Gille, Torsten Jonscher, Clemens Royla, Philipp Busse, Oliver Reschetilowski, Wladimir Weigand, Jan J.
Published in
Chemistry, an Asian Journal
A combination of synthesis, post‐synthesis and reaction technology to enhance aromatics yield and reduce coking in ethanol conversion on ZSM‐5 zeolite is a challenging and multidisciplinary task. A harmonization of product formation speed and product transport through catalyst grain and bed reveals unexpected resonance conditions explained by carbo...
Mazzotta, Sarah Carullo, Gabriele Schiano Moriello, Aniello Amodeo, Pietro Di Marzo, Vincenzo Vega-Holm, Margarita Vitale, Rosa Maria Aiello, Francesca Brizzi, Antonella De Petrocellis, Luciano
...
Published in
Marine Drugs
Labdane diterpenes are widespread classes of natural compounds present in variety of marine and terrestrial organisms and plants. Many of them represents “natural libraries” of compounds with interesting biological activities due to differently functionalized drimane nucleus exploitable for potential pharmacological applications. The transient rece...
Makume, Boitumelo F Holzapfel, Cedric W Maumela, Munaka C Willemse, J Alexander van den Berg, Jan A
Published in
ChemPlusChem
The effect of ethylene tetramerisation ligand structures on 1-octene selectivity is well studied. However, by-product formation is less understood. In this work, a range of PNP ligand structures are correlated with the full product selectivity and with catalyst activity. As steric bulk on the N-substituent increases, the product selectivity shifts ...
Georgiadis, Dimitris Ziotopoulou, Angeliki Kaloumenou, Eleni Lelis, Angelos Papasava, Antonia
Published in
Frontiers in Pharmacology
Insulin-Regulated Aminopeptidase (IRAP, EC 3.4.11.3) is a multi-tasking member of the M1 family of zinc aminopeptidases. Among its diverse biological functions, IRAP is a regulator of oxytocin levels during late stages of pregnancy, it affects cellular glucose uptake by trafficking of the glucose transporter type 4 and it mediates antigen cross-pre...
Pang, Bo Lam, Su Shiung Shen, Xiao-Jun Cao, Xue-Fei Liu, Shi-Jie Yuan, Tong-Qi Sun, Run-Cang
Published in
ChemSusChem
The valorization of lignin to replace phenol is significant in the production of phenolic resins. However, a great challenge is to produce lignin-based resin (LR) with a suitable viscosity and high substitution rate of lignin to phenol. In this study, LRs were produced using hardwood technical lignin derived from the pulping industry. Structural an...
Sonoda, Yoriko Tohnai, Norimitsu Shimoi, Yukihiro
Published in
ChemPlusChem
Crystal structures and fluorescence spectroscopic properties were investigated for a series of all-(E) α,ω-di(4-pyridyl)polyenes (1-5) with different number of double bonds (n). Molecules 1 and 2 (n=1, 2) in crystals are arranged to form partially π-overlapped structures, whereas those of 3-5 (n=3-5) are stacked in a herringbone fashion. All these ...
Cai, Xiaoming Liu, Xi Jiang, Jun Gao, Meng Wang, Weili Zheng, Huizhen Xu, Shujuan Li, Ruibin
Published in
Small (Weinheim an der Bergstrasse, Germany)
It is a big challenge to reveal the intrinsic cause of a nanotoxic effect due to diverse branches of signaling pathways induced by engineered nanomaterials (ENMs). Biotransformation of toxic ENMs involving biochemical reactions between nanoparticles (NPs) and biological systems has recently attracted substantial attention as it is regarded as the u...
