Han, A Lum Lee, Hee Kyung
Published in
Metabolites
Non-alcoholic fatty liver disease (NAFLD) was redefined as metabolic dysfunction-associated fatty liver disease (MAFLD) in 2020. Due to this, further validation of the non-invasive tests used in NAFLD diagnosis is required for MAFLD. There are five known steatosis indices for computed tomography (CT)-diagnosed MAFLD. These indices include the fatty...
Cao, Ye Luk, Ho Ming Zhang, Yanyan Chau, Matthew Hoi Kin Xue, Shuwen Cheng, Shirley S. W. Li, Albert Martin Chong, Josephine S. C. Leung, Tak Yeung Dong, Zirui
...
Published in
Frontiers in Genetics
Background: Structural variations (SVs) are various types of the genomic rearrangements encompassing at least 50 nucleotides. These include unbalanced gains or losses of DNA segments (copy number changes, CNVs), balanced rearrangements (such as inversion or translocations), and complex combinations of several distinct rearrangements. SVs are known ...
Zhang, Wei Wu, Minmin Gao, Xucan Ma, Chiyu Xu, Huixuan Lin, Liewen He, Jingquan Cai, Wanxia Zhong, Yafang Tang, Donge
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Published in
Frontiers in Cell and Developmental Biology
Background: The disturbed molecular alterations of nucleus may promote the development of colorectal cancer (CRC). A multi-platform-based analysis of nucleus of CRC patients helps us to better understand the underlying mechanism of CRC and screen out the potential drug targets for clinical treatment. However, such studies on nucleus in human CRC ar...
g., cassandria
Pangenomes aim to represent the complete repertoire of the genome diversity present within a species or cohort of species, capturing the genomic structural variance between individuals. This genomic information coupled with phenotypic data can be applied to identify genes and alleles involved with abiotic stress tolerance, disease resistance, and o...
Padariya, Monikaben Jooste, Mia-Lyn Hupp, Ted Fåhraeus, Robin Vojtesek, Borek Vollrath, Fritz Kalathiya, Umesh Karakostis, Konstantinos
The p53 tumor suppressor is a transcription factor with roles in cell development, apoptosis, oncogenesis, aging, and homeostasis in response to stresses and infections. p53 is tightly regulated by the MDM2 E3 ubiquitin ligase. The p53-MDM2 pathway has coevolved, with MDM2 remaining largely conserved, whereas the TP53 gene morphed into various isof...
Danilina, D. M. Nazimova, D. I. Konovalova, M. E.
Published in
Contemporary Problems of Ecology
AbstractThe results of stationary studies (1965–2017) on the regularities of the dynamics of the spatial structure of old-growth, cedar-pine forests are shown on the example of a natural-growth, cedar-pine sedge–tall herb–fern forest of the late succession stage (Western Sayan, 53°01′ N, 92°59′ E, individual test site area of 1.56 ha). It was found...
Gupta, Pushpendra K
Published in
Trends in genetics : TIG
For identification of marker-trait associations (MTAs) for complex traits in animals and plants, thousands of genome-wide association studies (GWAS) were conducted during the past two decades. This involved regular improvement in methodology. Initially, a reference genome and SNPs were used; more recently pan-genomes and the markers structural vari...
Yousaf, Aisha Liu, Junfeng Ye, Sicheng Chen, Hua
Published in
Frontiers in Genetics
The availability of high-quality genome sequences of great ape species provides unprecedented opportunities for genomic analyses. Herein, we reviewed the recent progress in evolutionary comparative genomic studies of the existing great ape species, including human, chimpanzee, bonobo, gorilla, and orangutan. We elaborate discovery on evolutionary h...
Wei, Neng Pérez-Escobar, Oscar A. Musili, Paul M. Huang, Wei-Chang Yang, Jun-Bo Hu, Ai-Qun Hu, Guang-Wan Grace, Olwen M. Wang, Qing-Feng
Published in
Frontiers in Plant Science
With c. 2,000 species, Euphorbia is one of the largest angiosperm genera, yet a lack of chloroplast genome (plastome) resources impedes a better understanding of its evolution. In this study, we assembled and annotated 28 plastomes from Euphorbiaceae, of which 15 were newly sequenced. Phylogenomic and comparative analyses of 22 plastome sequences f...
Cumer, Tristan Boyer, Frédéric Pompanon, François
Published in
Genome Biology and Evolution
During domestication processes, changes in selective pressures induce multiple phenotypical, physiological, and behavioral changes in target species. The rise of next-generation sequencing has provided a chance to study the genetics bases of these changes, most of the time based on single nucleotide polymorphisms (SNPs). However, several studies ha...
