2021 ESC Guidelines on cardiovascular disease prevention in clinical practice.
...Published in European journal of preventive cardiology
2021 ESC Guidelines on cardiovascular disease prevention in clinical practice.
...Published in European heart journal
Real-World Patterns of Pharmacotherapeutic Management of Asthma Patients With Exacerbations in the Spanish National Heal...
Published in Frontiers in Pharmacology
Background Little is known about the real1world characteristics of asthma patients with exacerbations or their pharmacotherapeutic management. We described the sociodemographic and clinical characteristics, and the patterns of short and long-term management of asthma attacks, in a population-wide cohort of exacerbators in the region of Valencia, Sp...
How focus creates engagement in Primary Design and Technology Education: The effect of well-defined tasks and joint pres...
During a Design and Technology class, engagement is both required to start creative hands-on work and a sign of pupil’s creative thinking. To find ways to achieve engagement, we can look to the Montessori tradition. Due to the fact that learning is regarded as feeding insight through experimenting, tasks have to offer pupils the opportunity to gain...
Improving the power to establish clinical similarity in a Phase 3 efficacy trial by incorporating prior evidence of anal...
Published in Journal of biopharmaceutical statistics
To improve patients' access to safe and effective biological medicines, abbreviated licensure pathways for biosimilar and interchangeable biological products have been established in the US, Europe, and other countries around the world. The US Food and Drug Administration and European Medicines Agency have published various guidance documents on th...
Constipation and fecal incontinence in children with cerebral palsy : overview of literature and flowchart for a stepwis...
Background and study aims : Constipation and fecal incontinence are common problems in neurologically impaired children. This paper aims to give an overview on bowel problems in cerebral palsy children and to suggest a stepwise treatment approach. A pubmed search was performed looking at studies during the past 20 years investigating bowel problems...
On sample size requirement for analytical similarity assessment.
Published in Journal of biopharmaceutical statistics
For approval of biosimilar products, the U.S. Food and Drug Administration (FDA) recommends a stepwise approach for obtaining the totality-of-the-evidence for assessing biosimilarirty between a proposed biosimilar product and its corresponding innovative (reference) biologic product. The stepwise approach starts with the assessment of analytical si...
Constipation and fecal incontinence in children with cerebral palsy. Overview of literature and flowchart for a stepwise...
Published in Acta gastro-enterologica Belgica
Constipation and fecal incontinence are common problems in neurologically impaired children. This paper aims to give an overview on bowel problems in cerebral palsy children and to suggest a stepwise treatment approach. A pubmed search was performed looking at studies during the past 20 years investigating bowel problems in neurologically disabled ...
Sample size requirement in analytical studies for similarity assessment.
Published in Journal of biopharmaceutical statistics
For the assessment of biosimilar products, the FDA recommends a stepwise approach for obtaining the totality-of-the-evidence for assessing biosimilarity between a proposed biosimilar product and its corresponding innovative biologic product. The stepwise approach starts with analytical studies for assessing similarity in critical quality attributes...
Diagnosis and Management of Drooling in Children With Progressive Dystonia: A Case Series of Patients With MEGDEL Syndro...
Published in Journal of child neurology
Drooling is a common problem in children with progressive dystonia. The authors noted a 58% incidence of drooling in 22/38 children with MEGDEL, a rare neurodegenerative cause of dystonia and report on the clinical course of four patients. Drooling of varying severity and subsequent respiratory problems were treated at the authors' multidisciplinar...
