Picerno, Angela Giannuzzi, Francesca Curci, Claudia De Palma, Giuseppe Di Chiano, Mariagiovanna Simone, Simona Franzin, Rossana Gallone, Anna Di Lorenzo, Vito Francesco Stasi, Alessandra
...
Published in
Stem cells (Dayton, Ohio)
The long non-coding RNAs (lncRNA) play an important role in several biological processes, including some renal diseases. Nevertheless, little is known about lncRNA that are expressed in the healthy kidneys and involved in renal cell homeostasis and development, and even less is known about lncRNA involved in the maintenance of human adult renal ste...
Egea-Zorrilla, Alejandro Vera, Laura Saez, Borja Pardo-Saganta, Ana
Published in
Cells
The lung epithelium is constantly exposed to harmful agents present in the air that we breathe making it highly susceptible to damage. However, in instances of injury to the lung, it exhibits a remarkable capacity to regenerate injured tissue thanks to the presence of distinct stem and progenitor cell populations along the airway and alveolar epith...
Nweke, Chukwuma E Stegemann, Jan P
Published in
Journal of biomedical materials research. Part B, Applied biomaterials
Biomaterial-based bone regeneration strategies often include a cellular component to accelerate healing. Modular approaches have the potential for minimally-invasive delivery and the ability to conformally fill complex defects. In this study, spherical gelatin microparticles were fabricated via water-in-oil emulsification and were subsequently cros...
man, rishi
Radiation-induced loss of the hematopoietic stem cell progenitor population compromises bone marrow regeneration and development of mature blood cells. Failure to rescue bone marrow functions results in fatal consequences from hematopoietic injury, systemic infections, and sepsis. So far, bone marrow transplant is the only effective option, which p...
al-lamee;, hannan
Recurrent implantation failure (RIF) and recurrent pregnancy loss (RPL), collectively referred to as recurrent reproductive failure (RRF), are both challenging conditions with many unanswered questions relating to causes and management options. Both conditions are proposed to be related to an aberrant endometrial microenvironment, with different pr...
Endo, Mitsuharu Kamizaki, Koki Minami, Yasuhiro
Published in
Frontiers in Cell and Developmental Biology
The Ror-family proteins, Ror1 and Ror2, act as receptors or co-receptors for Wnt5a and its related Wnt proteins to activate non-canonical Wnt signaling. Ror1 and/or Ror2-mediated signaling plays essential roles in regulating cell polarity, migration, proliferation and differentiation during developmental morphogenesis, tissue-/organo-genesis and re...
k., amaresh
Neurological/neurovascular disorders constitute the leading cause of disability and the second leading cause of death globally. Major neurological/neurovascular disorders or diseases include cerebral stroke, Alzheimer’s disease, spinal cord injury, neonatal hypoxic-ischemic encephalopathy, and others. Their pathophysiology is considered highly comp...
Overi, Diletta Carpino, Guido Moretti, Marta Franchitto, Antonio Nevi, Lorenzo Onori, Paolo De Smaele, Enrico Federici, Luca Santorelli, Daniele Maroder, Marella
...
Published in
Frontiers in Cell and Developmental Biology
Contrasting evidence is present regarding the contribution of stem/progenitor cell populations to pancreatic regeneration in diabetes. Interestingly, a cell compartment with stem/progenitor cell features has been identified in the pancreatic duct glands (PDGs). The aims of the present study were to evaluate pancreatic islet injury and regeneration,...
Cousins, Fiona L. Filby, Caitlin E. Gargett, Caroline E.
Published in
Frontiers in Reproductive Health
The human endometrium is a remarkable tissue, undergoing ~450 cycles of proliferation, differentiation, shedding (menstruation), repair, and regeneration over a woman's reproductive lifespan. Post-menstrual repair is an extremely rapid and scar-free process, with re-epithelialization of the luminal epithelium completed within 48 h of initiation of ...
Tan, Guak-Kim Pryce, Brian A Stabio, Anna Keene, Douglas R Tufa, Sara F Schweitzer, Ronen
Published in
Stem cell reports
Understanding cell recruitment in damaged tendons is critical for improvements in regenerative therapy. We recently reported that targeted disruption of transforming growth factor beta (TGFβ) type II receptor in the tendon cell lineage (Tgfbr2ScxCre) resulted in resident tenocyte dedifferentiation and tendon deterioration in postnatal stages. Here ...
