Mandl, Markus Viertler, Hans P Hatzmann, Florian M Brucker, Camille Großmann, Sonja Waldegger, Petra Rauchenwald, Tina Mattesich, Monika Zwierzina, Marit Pierer, Gerhard
...
Published in
Adipocyte
We established a functional adipose organoid model system for human adipose stem/progenitor cells (ASCs) isolated from white adipose tissue (WAT). ASCs were forced to self-aggregate by a hanging-drop technique. Afterwards, spheroids were transferred into agar-coated cell culture dishes to avoid plastic-adherence and dis-aggregation. Adipocyte diffe...
Jørgensen, Astrid S. Daugvilaite, Viktorija De Filippo, Katia Berg, Christian Mavri, Maša Benned-Jensen, Tau Juzenaite, Goda Hjortø, Gertrud Malene Rankin, Sara Våbenø, Jon
...
Following the FDA-approval of the hematopoietic stem cell (HSC) mobilizer plerixafor, orally available and potent CXCR4 antagonists were pursued. One such proposition was AMD11070, which was orally active and had superior antagonism in vitro / however, it did not appear as effective for HSC mobilization in vivo. Here we show that while AMD11070 act...
Amadasu, Efosa Kang, Richard Usmani, Ahsan Borlongan, Cesario V.
Published in
Cell Transplantation
Although brain tumors occur less frequently than other forms of cancer, they have one of the bleakest prognoses with low survival rates. The conventional treatment for brain tumors includes surgery, radiotherapy, and chemotherapy. However, resistance to treatment remains a problem with recurrence shortly following. The resistance to treatment may b...
Berthiaume, François Hsia, Henry C.
Chronic skin wounds are commonly found in older individuals who have impaired circulation due to diabetes or are immobilized due to physical disability. Chronic wounds pose a severe burden to the health-care system and are likely to become increasingly prevalent in aging populations. Various treatment approaches exist to help the healing process, a...
gyöngyösi;, mariann
Individual patient data (IPD)-based meta-analysis (ACCRUE, meta-analysis of cell-based cardiac studies, NCT01098591) revealed an insufficient effect of intracoronary cell-based therapy in acute myocardial infarction. Patients with ischemic heart failure (iHF) have been treated with reparative cells using percutaneous endocardial, surgical, transven...
duval;, tanguy
Purpose: With current gold standard treatment, which associates maximum safe surgery and chemo-radiation, the large majority of glioblastoma patients relapse within a year in the peritumoral non contrast-enhanced region (NCE). A subpopulation of glioblastoma stem-like cells (GSC) are known to be particularly radio-resistant and aggressive, and are ...
m., anton
The GLI-Similar 1-3 (GLIS1-3) genes, in addition to encoding GLIS1-3 Krüppel-like zinc finger transcription factors, also generate circular GLIS (circGLIS) RNAs. GLIS1-3 regulate gene transcription by binding to GLIS binding sites in target genes, whereas circGLIS RNAs largely act as miRNA sponges. GLIS1-3 play a critical role in the regulation of ...
Sørensen, Karam Matlub Jensen, Charlotte Harken Sheikh, Søren Paludan Qvist, Niels Sørensen, Jens Ahm
Published in
Inflammatory bowel diseases
Qiu, Haiyuan Guo, Rong Zhang, Yuanwen Ying, Jianghui Yan, Yazhou Xiong, Jiachao
Published in
Frontiers in Public Health
Background: Diabetes mellitus (DM) is a metabolic disease that endangers human health, and its prevalence is exploding and younger. Stem cell-derived extracellular vesicles (SC-EVs) have a repair function similar to SCs and no risk of tumor formation, which have been widely used in the repair of DM and its complications. We aim to map the hot trend...
Jaiswal, Amit Xudong, Zhu Zhenyu, Ju Saretzki, Gabriele
Published in
The FEBS journal
The mammalian sirtuin family consists of seven proteins, three of which (SIRT3, SIRT4, and SIRT5) localise specifically within mitochondria and preserve mitochondrial function and homeostasis. Mitochondrial sirtuins are involved in diverse functions such as deacetylation, ADP-ribosylation, demalonylation and desuccinylation, thus affecting various ...
