park, chan-wook lee, eun-mi shin, seung-han lee, chul won, jae-kyung
Our prior findings showed that BCL2A1 in neutrophils is highly expressed in the extra-placental membranes (EPMs) of both the human spontaneous preterm-birth (PTB) (i.e., PTL or preterm PROM) and nonhuman-primate PTB model. However, no data exist on whether the intensity of BCL2A1 expression quantitatively increases according to the stage progressio...
Mureanu, Nicoleta Bowman, Amanda M Porter-Wright, Imogen A Verma, Priya Efthymiou, Athina Nicolaides, Kypros H Scotta, Cristiano Lombardi, Giovanna Tribe, Rachel M Shangaris, Panicos
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Published in
International journal of molecular sciences
Spontaneous preterm birth (sPTB), defined as live birth before 37 weeks of gestational age, is associated with immune dysregulation and pro-inflammatory conditions that profoundly impact newborn health. The question of immune integrity at the maternal-foetal interface is a focus of recent studies centring not only sPTB but the conditions often affi...
Abheiden, Carolien N H Blomjous, Birgit S Slaager, Ciska Landman, Anadeijda J E M C Ket, Johannes C F Salmon, Jane E Buyon, Jill P Heymans, Martijn W de Vries, Johanna I P Bultink, Irene E M
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Published in
American journal of obstetrics and gynecology
Preterm birth is one of the most frequent complications of pregnancy in women with systemic lupus erythematosus. The high indicated preterm birth proportion due to hypertensive disorders of pregnancy and/or fetal growth restriction is well known, and preventive measures and screening for early detection are performed. The risk of spontaneous preter...
Lv, Wenqi Xie, Han Wu, Shengyu Dong, Jiaqi Jia, Yuanhui Ying, Hao
Published in
Frontiers in Endocrinology
Background Spontaneous preterm birth (sPTB) is a global disease that is a leading cause of death in neonates and children younger than 5 years of age. However, the etiology of sPTB remains poorly understood. Recent evidence has shown a strong association between metabolic disorders and sPTB. To determine the metabolic alterations in sPTB patients, ...
Becking, Ellis C.; Scheffer, Peter G.; Henrichs, Jens; Bax, Caroline J.; Crombag, Neeltje M.T.H.; 121732; Weiss, Marjan M.; Macville, Merryn V.E.; Van Opstal, Diane; Boon, Elles M.J.; Sistermans, Erik A.;
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BACKGROUND: Noninvasive prenatal testing by cell-free DNA analysis is offered to pregnant women worldwide to screen for fetal aneuploidies. In noninvasive prenatal testing, the fetal fraction of cell-free DNA in the maternal circulation is measured as a quality control parameter. Given that fetal cell-free DNA originates from the placenta, the feta...
hoffman, matthew k. kitto, carrie zhang, zugui shi, jing walker, michael g. shahbaba, babak ruhstaller, kelly
The AVERT PRETERM trial (NCT03151330) evaluated whether screening clinically low-risk pregnancies with a validated maternal blood biomarker test for spontaneous preterm birth (sPTB) risk, followed by preventive treatments for those screening positive, would improve neonatal outcomes compared to a clinically low-risk historical population that had r...
lee, kyong-no kim, youngmi bae, yeo kyeong hwang, jisong seo, yejin lee, keun-young lee, jae jun son, ga-hyun
Background: Preterm birth (PTB) is a significant challenge in contemporary obstetrics, affecting over one in ten infants worldwide and accounting for 75% of perinatal mortality. Short cervical length during mid-trimester is well known to be associated with an increased risk of spontaneous preterm birth (sPTB). Ultrasound-indicated cerclage (UIC) is...
Damanhuri, Narisa H Hairi, Noran N Ismail, Maslinor Jeganathan, Ravichandran Karalasingam, Shamala D Nasir, Muhammad Jaffri Mohd Soelar, Shahrul Aiman Musa, Kamarul Imran Tengku Ismail, Tengku Alina
Published in
Cureus
Background Spontaneous preterm birth (SPB) is a global public health concern with devastating health effects on SPB survivors. This study aimed to determine modifiable antenatal risk factors associated with SPB among women attending government healthcare facilities in Malaysia. Methodology A retrospective record review of 49,416 national obstetrics...
Zhang, Miaomiao Li, Shuilan Tian, Chao Li, Min Zhang, Baofang Yu, Hongkui
Published in
Frontiers in Physiology
Objective: To explore the feasibility of transvaginal ultrasound measurement of uterocervical angle (UCA) and cervical length (CL) in early and mid-pregnancy and evaluate their combined prediction of spontaneous preterm birth (sPTB) in singleton pregnancies. Patients and Methods: This retrospective study comprised 274 pregnant women who underwent t...
Woolner, Andrea M F Raja, Edwin Amalraj Bhattacharya, Sohinee Black, Mairead E
Published in
American journal of obstetrics and gynecology
Having a cesarean delivery at full dilatation has been associated with increased subsequent risk of spontaneous preterm birth. The Aberdeen Maternity and Neonatal Databank provides a rare opportunity to study subsequent pregnancy outcomes after a previous cesarean delivery at full dilatation over 40 years, with an ability to include a detailed eval...
