Harries, Lorna W
The FEBS journal
The human genome is capable of producing hundreds of thousands of different proteins and non-coding RNAs from
Zhang, Hong Jia, Jinbu Zhai, Jixian
Science China. Life sciences
Intron retention is the most common alternative splicing event in plants and plays a crucial role in the responses of plants to environmental signals. Despite a large number of RNA-seq libraries from different treatments and genetic mutants stored in public domains, a resource for querying the intron-splicing ratio of individual intron is still req...
Alternativno izrezovanje intronov in spajanje eksonov je aktualna raziskovalna tematika, o kateri je znanega že mnogo, pa vendar kljub številnim novim odkritjem še vedno obstaja precej neznank, ki na to razkritje še čakajo. Opisani so različni naravni mehanizmi tega procesa, mnogi pa so v raziskovalnih delih tudi inženirsko poustvarjeni. V tej magi...
Khatri, Deepak Putoux, Audrey Cologne, Audric Kaltenbach, Sophie Besson, Alicia Bertiaux, Eloïse Guguin, Justine Fendler, Adèle Dupont, Marie Benoit-Pilven, Clara
In the human genome, about 750 genes contain one intron excised by the minor spliceosome. This spliceosome comprises its own set of snRNAs, among which U4atac. Its noncoding gene, , has been found mutated in Taybi-Linder (TALS/microcephalic osteodysplastic primordial dwarfism type 1), Roifman (RFMN), and Lowry-Wood (LWS) syndromes. These rare devel...
Gingerich, Morgan A Liu, Xueying Chai, Biaoxin Pearson, Gemma L Vincent, Michael P Stromer, Tracy Zhu, Jie Sidarala, Vaibhav Renberg, Aaron Sahu, Debashish
CLEC16A regulates mitochondrial health through mitophagy and is associated with over 20 human diseases. However, the key structural and functional regions of CLEC16A, and their relevance for human disease, remain unknown. Here, we report that a disease-associated CLEC16A variant lacks a C-terminal intrinsically disordered protein region (IDPR) that...
Becatti, Matteo Dmello, Crismita Kumar, Binod
Frontiers in Molecular Biosciences
Bajsa-Hirschel, Joanna Pan, Zhiqiang Pandey, Pankaj Asolkar, Ratnakar N. Chittiboyina, Amar G. Boddy, Louis Machingura, Marylou C. Duke, Stephen O.
Frontiers in Plant Science
Spliceostatin C (SPC) is a component of a bioherbicide isolated from the soil bacterium Burkholderia rinojensis. The chemical structure of SPC closely resembles spliceostatin A (SPA) which was characterized as an anticancer agent and splicing inhibitor. SPC inhibited the growth of Arabidopsis thaliana seedlings with an IC50 value of 2.2 µM. The see...
Lothion-Roy, Jennifer Haigh, Daisy B. Harris, Anna E. Metzler, Veronika M. Alsaleem, Mansour Toss, Michael S. Kariri, Yousif Ntekim, Atara Robinson, Brian D. Khani, Francesca
Frontiers in Genetics
N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the m6A modification. These proteins, and the m6A modification, are involved in the regulation of gene expression, RNA stability, splicing and translation. Given its r...
Markowski, Adam Zaremba-Czogalla, Magdalena Jaromin, Anna Olczak, Ewa Zygmunt, Adrianna Etezadi, Haniyeh Boyd, Ben J Gubernator, Jerzy
Pancreatic cancer (PC) is one of the deadliest cancers so there is an urgent need to develop new drugs and therapies to treat it. Liposome-based formulations of naturally-derived bioactive compounds are promising anticancer candidates due to their potential for passive accumulation in tumor tissues, protection against payload degradation, and preve...
Bhattarai, Krishna Holcik, Martin
Frontiers in Virology
Understanding the host-virus interactions helps to decipher the viral replication strategies and pathogenesis. Viruses have limited genetic content and rely significantly on their host cell to establish a successful infection. Viruses depend on the host for a broad spectrum of cellular RNA-binding proteins (RBPs) throughout their life cycle. One of...