Stolbovaya, A. Yu. Smirnov, I. V. Pinevich, A. A. Berlina, M. A. Kozyreva, A. R. Shashkova, O. A. Sokolov, D. I. Selkov, S. A. Samoilovich, M. P.
Published in
Cell and Tissue Biology
AbstractThe endothelium of blood vessels plays an important role in the regulation of normal and pathological processes occurring in the tissues. Monoclonal antibodies (MAbs) to endoglin (CD105), a marker of endothelial cells, are considered as potential agents to affect the functional characteristics of endothelial cells. Here, we report the abili...
Zhang, Luyan Li, Xuechun Zhou, Chengcheng You, Zhengming Zhang, Jianwei Cao, Guomei
Published in
Journal of clinical laboratory analysis
To detect the levels of signal transducer and activator of transcription 4 (STAT4) and soluble endoglin (sEng) in preeclampsia patients and analyze the diagnostic values of STAT4 and sEng in preeclampsia. Fifty-four pregnant women with preeclampsia from October 2017 to June 2018 were included in this study. Twenty-eight matched healthy pregnant wom...
Lawera, Aleksandra Tong, Zhen Thorikay, Midory Redgrave, Rachael E. Cai, Jie van Dinther, Maarten Morrell, Nicholas W. Afink, Gijs B. Charnock-Jones, D. Stephen Arthur, Helen M.
...
Published in
Proceedings of the National Academy of Sciences of the United States of America
Endoglin (ENG) is a coreceptor of the transforming growth factor-β (TGFβ) family signaling complex, which is highly expressed on endothelial cells and plays a key role in angiogenesis. Its extracellular domain can be cleaved and released into the circulation as soluble ENG (sENG). High circulating levels of sENG contribute to the pathogenesis of pr...
Schmella, Mandy J Assibey-Mensah, Vanessa Parks, W Tony Roberts, James M Jeyabalan, Arun Hubel, Carl A Catov, Janet M
Published in
Placenta
We evaluated the association between plasma soluble endoglin (sENG) and maternal vascular malperfusion (MVM) lesions of the placenta in women with preeclampsia. We measured sENG (sCD105) by ELISA in N = 70 women diagnosed with preeclampsia (median [IQR] GA at sampling = 36.4 [6.0] weeks) and available placental pathology. Placental pathology report...
Raia-Barjat, Tiphaine Prieux, Carole Gris, Jean-Christophe Chapelle, Céline Laporte, Silvy Chauleur, Céline
Published in
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
The study aimed to compare the level of two angiogenic factors, soluble fms-like tyrosine kinase-1 (sFlt1) and soluble endoglin (sEng), for the prediction of preeclampsia and intrauterine growth restriction in high-risk pregnant women. A prospective multicenter cohort study of 200 pregnant patients was conducted between June 2008 and October 2010. ...
Nanjo, Sakiko Minami, Sawako Mizoguchi, Mika Yamamoto, Madoka Yahata, Tamaki Toujima, Saori Shiro, Michihisa Kobayashi, Aya Muragaki, Yasuteru Ino, Kazuhiko
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Published in
The journal of obstetrics and gynaecology research
We aimed to investigate maternal serum angiogenic marker profiles within 1 week prior to delivery in cases of gestational hypertension (GH), pre-eclampsia (PE), and/or fetal growth restriction (FGR) with different clinical conditions. We enrolled 165 women with singleton pregnancy. The participants were classified based on three characteristics: (i...
Conroy, Andrea L McDonald, Chloe R Gamble, Joel L Olwoch, Peter Natureeba, Paul Cohan, Deborah Kamya, Moses R Havlir, Diane V Dorsey, Grant Kain, Kevin C
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Published in
American journal of obstetrics and gynecology
An antiangiogenic state in the second or third trimester is associated with adverse birth outcomes, including stillbirth in women and adolescents living with HIV and receiving antiretroviral therapy.
Conroy, Andrea L McDonald, Chloe R Gamble, Joel L Olwoch, Peter Natureeba, Paul Cohan, Deborah Kamya, Moses R Havlir, Diane V Dorsey, Grant Kain, Kevin C
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Angiogenic processes in the placenta are critical regulators of fetal growth and impact birth outcomes, but there are limited data documenting these processes in HIV-infected women or women from low-resource settings.We sought to determine whether angiogenic factors are associated with adverse birth outcomes in HIV-infected pregnant women started o...
Cim, Numan Kurdoglu, Mertihan Ege, Serhat Yoruk, Ibrahim Yaman, Gorkem Yildizhan, Recep
Published in
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
The aim of this study was to evaluate the roles of proangiogenic factors including serum vitamin D and vascular endothelial growth factor (VEGF) and anti-angiogenic factors including soluble endoglin (sEng) and soluble fms-like tyrosine kinase 1 (sFlt1) in the diagnosis and severity of late-onset preeclampsia. The study was conducted at Yuzuncu Yil...
Nakashima, Akitoshi Aoki, Aiko Kusabiraki, Tae Shima, Tomoko Yoshino, Osamu Cheng, Shi-Bin Sharma, Surendra Saito, Shigeru
Published in
The journal of obstetrics and gynaecology research
Autophagy is a well-conserved mechanism in cells from yeast to mammals, and autophagy maintains homeostasis against stress. The role of autophagy was originally shown to be a mechanism of energy production under starvation. In fact, multiple lines of evidence reveal that autophagy has numerous functions, such as protection from stress, energy regul...
