(Meth)acrylate polymers are commonly used as photoresist materials in photolithography. However, these polymers encounter the problem of swelling during the development process. To address this, we explored the use of a hydrophobic group to control the solubility in the hydrophilic developer. In this study, we synthesized two types of polymers to e...
Backgroud/Objectives: Silymarin, an extract from milk thistle, is widely recognized for its therapeutic potential in treating liver disorders. However, its clinical utility is limited by the poor solubility and low bioavailability of its key active ingredient, Silybin. In this study, we sought to address this issue through the development of a nove...
Apigenin (APG), a bioactive flavonoid with promising therapeutic potential, suffers from poor water solubility, which limits its bioavailability. To address this, solid dispersions of APG were prepared using ball milling with sodium alginate (SA), Pluronic® F-68 (PLU68), Pluronic® F-127 (PLU127), PVP K30, and PVP VA64 as polymeric excipients. These...
This study investigated the impact of natural compound enrichment, specifically quercetin and trans, trans-farnesol (tt-farnesol), on the physicochemical properties of a universal adhesive system. A preliminary DPPH assay was conducted to determine the optimal concentrations of quercetin (0.24 mg/mL) and tt-farnesol (1.43 mg/mL) based on their radi...
To improve the low solubility of poorly water soluble olaparib, in the following study, we prepared olaparib-loaded quaternary solid dispersions with hypromellose, Tween 20 or Labrasol, and colloidal silica. The solubility of olaparib with various types of surfactants was evaluated to select the most suitable surfactant to effectively enhance its s...
The implications of various pH solutions in the gastrointestinal fluid system as solvent-mediated phase transitions on concurrent polymorphism transformation, notably metastable polymorphic forms of Efavirenz (EFV), has never been investigated. The impact will be shifting in the solubility and crystallinity of EFV polymorphisms, particularly metast...
The complete dissolution of the Ti and Fe content of ilmenite is a necessary first step for the production of TiO2 directly from ilmenite. Hydrochloric acid is one of the possible solubilizing agents. However, the ability to dissolve ilmenite in hydrochloric acid depends on the nature of the source material. Here, we consider the effect that the ox...
Background: Curcumin appears to be well tolerated and effective for managing chronic inflammatory pain, but its poor oral bioavailability has been a hurdle in its use as a therapeutic agent. The current study was performed to characterize a novel co-amorphous compound based on curcumin/L-arginine 1:2 (CAC12). Methods: Stability, solubility and stru...
Naproxen (NAP) is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the arylpropionic acid class. Classified as a Biopharmaceutical Classification System (BCS) class II drug, NAP exhibits low water solubility, thus resulting in restricted oral bioavailability. This study aimed to evaluate the effectiveness of pharmaceutical salts in en...
There are millions of tons of fresh soy sauce residue (SSR) by-products created by China’s soy sauce industry every year. Most of the SSR is directly discarded; this not only wastes resources, but also pollutes the environment. As it is rich in dietary fiber, which is beneficial to human health, skimmed SSR was used as a raw material to obtain solu...
