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Decreased hepatic microsomal cytochrome P450 due to indomethacin: Protective roles of 16,16-dimethylprostaglandin F 2α a...

Published in Biochemical Pharmacology

Indomethacin administration to rats caused a dose-dependent decrease in hepatic microsomal cytochrome P450, aminopyrine N-demethylase, ethoxyresorufin O-de-ethylase and benzyloxyresorufin O-debenzylase, accompanied by selective alterations in microsomal sodium dodecylsulphate polyacrylamide gel electrophoretograms. High doses (⪖8.5 mg/kg) caused th...