Nolano, Maria Tozza, Stefano Caporaso, Giuseppe Provitera, Vincenzo
Published in
Brain Sciences
In the last three decades the study of cutaneous innervation through 3 mm-punch-biopsy has provided an important contribution to the knowledge of small fiber somatic and autonomic neuropathies but also of large fiber neuropathies. Skin biopsy is a minimally invasive technique with the advantage, compared to sural nerve biopsy, of being suitable to ...
Vecchio, Michele Chiaramonte, Rita Romano, Marcello Pavone, Piero Musumeci, Giuseppe Mauro, Giulia Letizia
Published in
Diagnostics (Basel, Switzerland)
The aim of this systematic review is to guide the physician in defining the pharmacologic and rehabilitative therapeutic approaches for adopting the best strategies described in the current literature. The search was conducted in PubMed, EMBASE, Cochrane Library and Web of Science to identify the treatment of small fiber neuropathies. Two reviewers...
Cox, James J. Woods, C. Geoffrey Kurth, Ingo
Published in
Medizinische Genetik
Peripheral sensory neurons are afferent neurons that innervate the skin, joints, bones, muscles, and mucosal tissues. By converting different stimuli into action potentials, they transmit signals for the sensing of temperature, touch, pressure, or pain. This review discusses the known Mendelian disorders which affect pain sensing in humans. For pai...
Shin, Changsun Lee, Meonghun
Published in
Sensors (Basel, Switzerland)
The swarm intelligence (SI)-based bio-inspired algorithm demonstrates features of heterogeneous individual agents, such as stability, scalability, and adaptability, in distributed and autonomous environments. The said algorithm will be applied to the communication network environment to overcome the limitations of wireless sensor networks (WSNs). H...
Chiaramonte, Rita Romano, Marcello Vecchio, Michele
Published in
Diagnostics
This systematic review describes the several methods to diagnose and measure the severity of small fiber neuropathies and aims to guide the physician to define all the diagnostic approaches for adopting the best strategies described in the current literature. The search was conducted in PubMed, EMBASE, Cochrane Library and Web of Science. Two revie...
Ghasemi, Majid Rajabally, Yusuf A
Published in
Muscle & nerve
Small fiber neuropathy (SFN) is being recognized with increasing frequency in neuromuscular practice due to improved diagnostic techniques. Although there are some common etiologies, up to one-third of cases are considered idiopathic. In recent years, several disorders have unexpectedly been reported in association with SFN, on clinical grounds and...
Parikh, Prachi Polston, David Li, Yuebing
Published in
Muscle & nerve
We aimed to evaluate the significance of electromyographic findings in the intrinsic foot muscles (IFMs) of patients with skin biopsy proven small fiber neuropathy (SFN). This was a single-center retrospective analysis of patients who underwent skin biopsy for intra-epidermal nerve fiber density (IENFD) measurement and electrodiagnostic (EDX) study...
Porubcin, Michal G Novak, Peter
Published in
Frontiers in neurology
Background: Small fiber neuropathy (SFN) is a common health problem. SFN is associated with loss of small fibers, either sensory, autonomic or both. Reduced autonomic sudomotor sweat gland nerve fiber density (SGNFD) and sensory epidermal nerve fiber density (ENFD) can be seen in SFN. Electrochemical skin conductance (ESC) is a non-invasive test fo...
Farschtschi, Said C Kluwe, Lan Schön, Gerhard Friedrich, Reinhard E Matschke, Jakob Glatzel, Markus Weis, Joachim Hagel, Christian Mautner, Victor-Felix
Published in
Brain pathology (Zurich, Switzerland)
Schwannomatosis and neurofibromatosis type 2 (NF2) are two distinct neuro-genetic tumor predisposition disorders, which, however, share some clinical and genetic features. While germline mutations in the NF2 gene are only found in NF2, a majority of schwannomatosis patients have germline mutations in the SMARCB1 or LZTR1 genes. The overlapping clin...
Rosenberg, Michael L. Tohidi, Vahid Sherwood, Karna Gayen, Sujoy Medel, Rosina Gilad, Gad M.
Published in
Nutrients
Peripheral neuropathies associated with painful small fiber neuropathy (SFN) are complex conditions, resistant to treatment with conventional medications. Previous clinical studies strongly support the use of dietary agmatine as a safe and effective treatment for neuropathic pain. Based on this evidence, we conducted an open-label consecutive case ...