Rosenberg, Michael L. Tohidi, Vahid Sherwood, Karna Gayen, Sujoy Medel, Rosina Gilad, Gad M.
Published in
Nutrients
Peripheral neuropathies associated with painful small fiber neuropathy (SFN) are complex conditions, resistant to treatment with conventional medications. Previous clinical studies strongly support the use of dietary agmatine as a safe and effective treatment for neuropathic pain. Based on this evidence, we conducted an open-label consecutive case ...
Timmins, Hannah C Li, Tiffany Kiernan, Matthew C Horvath, Lisa G Goldstein, David Park, Susanna B
Published in
The journal of pain : official journal of the American Pain Society
Chemotherapy-induced peripheral neuropathy (CIPN) is a major, dose-limiting side effect of treatment with neurotoxic cancer treatments which can result in long-term impairment. Deficits often reflect a large fiber polyneuropathy, however small fiber involvement resulting in neuropathic pain and autonomic dysfunction can occur. Quantification of bot...
Görlach, Jonas Amsel, Daniel Kölbel, Heike Grzybowsky, Michelle Rutsch, Frank Schlierbach, Hannah Vanlander, Arnaud Pogatzki-Zahn, Esther Habig, Kathrin Garkisch, Stefanie
...
Published in
Muscle & nerve
Small fiber neuropathies (SFN) are associated with a reduction in quality of life. In adults, epidermal nerve fiber density (END) analysis is recommended for the diagnosis of SFN. In children, END assessment is not often performed. We analyzed small nerve fiber innervation to elucidate the potential diagnostic role of skin biopsies in young patient...
Moulton, Eric A. Borsook, David
Published in
Brain Sciences
C-fibers are unmyelinated nerve fibers that transmit high threshold mechanical, thermal, and chemical signals that are associated with pain sensations. This review examines current literature on measuring altered peripheral nerve morphology and discusses the most relevant aspects of corneal microscopy, especially whether corneal imaging presents si...
Ryabkova, Varvara A. Churilov, Leonid P. Shoenfeld, Yehuda
Published in
International Journal of Molecular Sciences
Fibromyalgia is a disorder characterized by chronic widespread pain and non-pain symptoms, such as fatigue, dysautonomia, and cognitive and sleep disturbances. Its pathogenesis and treatment continue to be the subject of debate. We highlight the role of three mechanisms—autoimmunity, neuroinflammation, and small fiber neuropathy—in the pathogenesis...
Nielson Hoberg, Tatiana Frahm, Steffen Hennings, Kristian Arendt-Nielsen, Lars Dahl Mørch, Carsten
Published in
Muscle & nerve
Topical application of lidocaine-and-prilocaine (LP) cream attenuates the functionality of small cutaneous nerve fibers. The aim of this human study was to measure the underlying excitability modulation of small cutaneous nerve fibers using a novel and fast perception threshold tracking (PTT) technique. Small sensory fibers were selectively blocked...
Zis, Panagiotis Sarrigiannis, Ptolemaios Georgios Rao, Dasappaiah Ganesh Sanders, David Surendran Hadjivassiliou, Marios
Published in
Postgraduate medicine
Objectives: The commonest types of peripheral neuropathy in the context of Coeliac Disease (CD) and gluten sensitivity (GS) are length-dependent symmetrical sensorimotor neuropathies and sensory ganglionopathies. In patients with such neuropathy, (gluten neuropathy), peripheral neuropathic pain is prevalent suggesting involvement of small fibers. T...
Cho, Eun Bin Seok, Jin Myoung Min, Ju-Hong Suh, Bum Chun Park, Ki-Jong Kim, Byoung Joon
Published in
Journal of Clinical Neurology (Seoul, Korea)
Background and Purpose Diagnosing small-fiber neuropathy (SFN) is challenging because there is no gold-standard test and few diagnostic tests. This study investigated the clinical symptom profile and its associations with the results of quantitative sensory testing (QST) and the quantitative sudomotor axon reflex test (QSART) as well as the quality...
Jeziorska, Maria Atkinson, Andrew Kass-Iliyya, Lewis Javed, Saad Kobylecki, Christopher Gosal, David Marshall, Andrew Silverdale, Monty Malik, Rayaz A.
Published in
Frontiers in Neurology
Background: Previous studies have shown cutaneous small fiber pathology in patients with Parkinson's disease (PD). These studies have focused on nerve degeneration, but recent reports suggest that nerve regeneration may also be important in PD pathology. Objective: To establish the extent of intraepidermal nerve fiber (IENF) degeneration and regene...
Foschi, Matteo Vacchiano, Veria Avoni, Patrizia Incensi, Alex Battaglia, Stella Donadio, Vincenzo Panzeri, Elena Bassi, Maria Teresa Liguori, Rocco Rizzo, Giovanni
...
Published in
Frontiers in Neurology
X-linked adrenoleukodystrophy (x-ALD) is a rare genetic disorder caused by a mutation in the ABCD1 gene, which encodes for a peroxisomal very long chain fatty acid transporter. Clinically, x-ALD can present a wide spectrum of different phenotypes: asymptomatic carriers, Addison only, cerebral x-ALD, and myelopathy with/without evidence of periphera...
