Heerfordt, Ida M Poulsen, Thomas Wulf, Hans Christian
Published in
Journal of clinical pathology
Actinic keratosis (AK) is a precursor of cutaneous squamous cell carcinoma (SCC). No validated parameters can predict which AKs will progress into SCCs, but especially thick AKs are under suspicion. The clinical and histopathological thickness of AKs is strongly correlated. This study aimed to investigate the thicknesses and degree of dysplasia of ...
Pyatilova, Polina Ashry, Tameem Luo, Yanyan He, Jiajun Bonnekoh, Hanna Jiao, Qingqing Moñino-Romero, Sherezade Hu, Man Scheffel, Jörg Frischbutter, Stefan
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Published in
Frontiers in Immunology
Background Recently, the expression of the mast cell (MC) receptor Mas-related G protein–coupled receptor X2 (MRGPRX2) has been detected in lesional skin of adult patients with cutaneous mastocytosis. As of yet, little is known about the clinical relevance of MRGPRX2 and its agonists in patients with mastocytosis, including indolent systemic mastoc...
Wang, Junjie Zhen, Zhen Wang, Yanqing Wu, Runlong Hu, Yanhui Fu, Qiang Li, Yongzhi Xin, Bingmu Song, Jinping Li, Jianwei
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Published in
Frontiers in Physiology
Spaceflight presents a series of physiological and pathological challenges to astronauts resulting from ionizing radiation, microgravity, isolation, and other spaceflight hazards. These risks cause a series of aging-related diseases associated with increased oxidative stress and mitochondria dysfunction. The skin contains many autofluorescent subst...
Liu, E Gao, Hongjin Zhao, YiJia Pang, Yaobing Yao, Yejing Yang, Zhengru Zhang, Xueer Wang, YanJin Yang, Siming Ma, Xiao
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Published in
Frontiers in Pharmacology
Under normal circumstances, wound healing can be summarized as three processes. These include inflammation, proliferation, and remodeling. The vast majority of wounds heal rapidly; however, a large percentage of nonhealing wounds have still not been studied significantly. The factors affecting wound nonhealing are complex and diverse, and identifyi...
Jones, Christian F. E. Di Cio, Stefania Connelly, John T. Gautrot, Julien E.
Published in
Frontiers in Bioengineering and Biotechnology
Tissue-engineered skin constructs have been under development since the 1980s as a replacement for human skin tissues and animal models for therapeutics and cosmetic testing. These have evolved from simple single-cell assays to increasingly complex models with integrated dermal equivalents and multiple cell types including a dermis, epidermis, and ...
Wang, Zhao Li, Zhuoran Bal, Gürkan Franke, Kristin Zuberbier, Torsten Babina, Magda
Published in
Frontiers in Allergy
As a novel receptor that efficiently elicits degranulation upon binding to one of its numerous ligands, MRGPRX2 has moved to the center of attention in mast cell (MC) research. Indeed, MRGPRX2 is believed to be a major component of pseudo-allergic reactions to drugs and of neuropeptide-elicited MC activation in skin diseases alike. MRGPRX2 signals ...
Su, Shaofeng Wu, Hongxian Zhou, Jingfan Yuan, Guangwei Wang, Haibo Feng, Jie
Published in
Molecules (Basel, Switzerland)
Curcumin and germacrone, natural products present in the Zingiberaceae family of plants, have several biological properties. Among these properties, the anti-NSCLC cancer action is noteworthy. In this paper, kinetics of the two compounds in rat liver microsomes (RLMs), human liver microsomes (HLMs), and cytochrome P450 (CYP) enzymes (CYP3A4, 1A2, 2...
Pan, Yu Du, Dan Wang, Lian Wang, Xiaoyun He, Gu Jiang, Xian
Published in
Frontiers in Immunology
T helper 22 (Th22) cells are a newly identified subset of CD4+ T cells that secrete the effector cytokine interleukin 22 (IL-22) upon specific antigen stimulation, barely with IFN-γ or IL-17. Increasing studies have demonstrated that Th22 cells and IL-22 play essential roles in skin barrier defense and skin disease pathogenesis since the IL-22 rece...
Sychrová, Alice Škovranová, Gabriela Čulenová, Marie Bittner Fialová, Silvia
Published in
Molecules (Basel, Switzerland)
The review presents prenylated flavonoids as potential therapeutic agents for the treatment of topical skin infections and wounds, as they can restore the balance in the wound microenvironment. A thorough two-stage search of scientific papers published between 2000 and 2022 was conducted, with independent assessment of results by two reviewers. The...
Tan, Fei Wang, Yang Zhang, Shiqun Shui, Runying Chen, Jianghan
Published in
Frontiers in Oncology
Cold atmospheric plasma-based plasma medicine has been expanding the diversity of its specialties. As an emerging branch, plasma dermatology takes advantage of the beneficial complexity of plasma constituents (e.g., reactive oxygen and nitrogen species, UV photons, and electromagnetic emission), technical versatility (e.g., direct irradiation and i...
