Uvod: Pri uravnavanju normalne koncentracije glukoze v krvi sodelujejo skeletne mišice, presnovno eno najbolj aktivnih tkiv in pomembno mesto od inzulina odvisnega privzema glukoze po obroku. Za ohranjanje energijske homeostaze je pomembna z AMP aktivirana kinaza (AMPK). AMPK je tudi zanimiva tarča za razvoj novih oblik zdravljenja inzulinske rezis...
Published in The Journal of physiology
Published in Journal of cardiac failure
Skeletal muscle is quantitatively and qualitatively impaired in patients with heart failure (HF), which is closely linked to lowered exercise capacity. Ultrasonography (US) for skeletal muscle has emerged as a useful, noninvasive tool to evaluate muscle quality and quantity. Here we investigated whether muscle quality based on US-derived echo inten...
Published in Journal of the American College of Nutrition
Objective: Pyrroloquinoline quinone (PQQ) is a novel supplement involved in processes such as mitochondrial biogenesis and cellular energy metabolism. Since endurance exercise and PQQ exhibit similar mechanisms for mitochondrial biogenesis, it is plausible that PQQ may have ergogenic value. Therefore, the purpose of this study was to examine the ef...
Published in Physiological reports
Skeletal muscle and extracellular vesicle (EV) miRNA expression increases following acute endurance exercise. However, research to date has only been performed in males. The aim of this study was to describe the expression levels of a subset of miRNAs in EVs following acute exercise and compare it to skeletal muscle miRNA expression. Twelve males (...
Published in Neuroscience
Since the pioneering works of Ricardo Miledi, the neuromuscular junction represents the best example of a synapse where ACh is the neurotransmitter acting on nicotinic ACh receptors. ATP, co-released with ACh, is promptly degraded to Ado, which acts as a modulator of the cholinergic synaptic activity. Consequently, both ACh and adenosine play a cru...
A common shortcoming of current tissue engineered constructs is the lack of a functional vasculature, limiting their size and functionality. Prevascularization is a possible strategy to introduce vascular networks in these constructs. It includes among others co-culturing target cells with endothelial (precursor) cells that are able to form endothe...
Published in Insects
Research on coprophagous beetles of the Hydrophilidae family in the Polish Carpathians was conducted from 2011 to 2013. The beetles were caught using baited traps. The research sites were selected to take into account both the horizontal diversity of habitat conditions and the vertical diversity associated with elevation above sea level. During the...
Distinctly organized microtubule networks contribute to the function of differentiated cell types such as neurons, epithelial cells, skeletal myotubes, and cardiomyocytes. In striated (i.e. skeletal and cardiac) muscle cells, the nuclear envelope acts as the dominant microtubule-organizing center (MTOC) and the function of the centrosome&mdash / th...
Striated muscle contraction involves sliding of actin thin filaments along myosin thick filaments, controlled by calcium through thin filament activation. In relaxed muscle, the two heads of myosin interact with each other on the filament surface to form the interacting-heads motif (IHM). A key question is how both heads are released from the surfa...
