zhang, zhenyu xiaoming, ma yongfu, la guo, xian chu, min bao, pengjia yan, ping xiaoyun, wu liang, chunnian
Single-cell sequencing technology provides apparent advantages in cell population heterogeneity, allowing individuals to better comprehend tissues and organs. Sequencing technology is currently moving beyond the standard transcriptome to the single-cell level, which is likely to bring new insights into the function of breast cells. In this study, w...
Uchigashima, Motokazu Mikuni, Takayasu
Published in
Frontiers in Neural Circuits
Our brain adapts to the environment by optimizing its function through experience-dependent cortical plasticity. This plasticity is transiently enhanced during a developmental stage, known as the “critical period,” and subsequently maintained at lower levels throughout adulthood. Thus, understanding the mechanism underlying critical period plastici...
Liu, Han Da, Wacili Mu, Jianhua He, Xuanhong Li, Zhuangzhuang Gong, Taojun Wang, Jingjing Min, Li Lu, Minxun Tu, Chongqi
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Published in
Frontiers in Genetics
Background Platelets are associated with poor prognosis in most tumors, but their specific pathogenic mechanism in osteosarcoma is not yet clear. The objective of this study is to conduct an in-depth analysis of how genes closely related to platelet function impact the prognosis of osteosarcoma patients. We hope that through this research, we can u...
Akimov, Vasiliy E. Tychinin, Dmitriy I. Antonova, Olga A. Shaymardanov, Abusaid M. Voronina, Maria D. Deinichenko, Kseniia A. Fateev, Oleg D. Yudin, Vladimir S. Yudin, Sergey M. Mukhin, Vladimir E.
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Published in
Frontiers in Immunology
COVID-19 is characterized by systemic pro-inflammatory shifts with the development of serious alterations in the functioning of the immune system. Investigations of the gene expression changes accompanying the infection state provide insight into the molecular and cellular processes depending on the sickness severity and virus variants. Severe Delt...
Cai, Linfeng Lin, Li Lin, Shiyan Wang, Xuanqun Chen, Yingwen Zhu, Huanghuang Zhu, Zhi Yang, Liu Xu, Xing Yang, Chaoyong
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Published in
Small methods
Proteins as crucial components of cells are responsible for the majority of cellular processes. Sensitive and efficient protein detection enables a more accurate and comprehensive investigation of cellular phenotypes and life activities. Here, a protein sequencing method with high multiplexing, high throughput, high cell utilization, and integratio...
Shao, Tuo Gao, Qichang Tang, Weilong Ma, Yiming Gu, Jiaao Yu, Zhange
Published in
Inflammation
Immune infiltration plays a crucial role in intervertebral disc degeneration (IDD). In this study, we explored the immune microenvironment of IDD through single-cell bioinformatics analysis. Three single-cell datasets were integrated into this study. Nucleus pulposus cells (NPCs) were divided into subgroups based on characteristic genes, and the ro...
Adegoke, Abdulsalam Ribeiro, Jose M. C. Smith, Ryan C. Karim, Shahid
Published in
Frontiers in Immunology
peng, bo pan, lixia wenhui, li
The hepatitis B virus (HBV) infects approximately 290 million people globally, with chronic infection sustained by persistent viral gene expression. Recent single-cell analyses of HBV viral transcripts have uncovered novel features of HBV transcription and provided fresh insights into its regulation at the single-cell level. In this review, we summ...
Chao, Lin Chan, Chun Shi, Chao Rang, Ulla
Lineages of rod-shaped bacteria such as Escherichia coli exhibit a temporal decline in elongation rate in a manner comparable to cellular or biological aging. The effect results from the production of asymmetrical daughters, one with a lower elongation rate, by the division of a mother cell. The slower daughter compared to the faster daughter, deno...
wang, helen h. korah, maria jing, serena l. berry, charlotte e. griffin, michelle f. longaker, michael t. januszyk, michael
Diabetes mellitus is an increasingly prevalent chronic metabolic disorder characterized by physiologic hyperglycemia that, when left uncontrolled, can lead to significant complications in multiple organs. Diabetic wounds are common in the general population, yet the underlying mechanism of impaired healing in such wounds remains unclear. Single-cel...
