Menghini, Stefano Ho, Ping Shu Gwisai, Tinotenda Schuerle, Simone
Published in
International journal of molecular sciences
Interest has grown in harnessing biological agents for cancer treatment as dynamic vectors with enhanced tumor targeting. While bacterial traits such as proliferation in tumors, modulation of an immune response, and local secretion of toxins have been well studied, less is known about bacteria as competitors for nutrients. Here, we investigated the...
Scott, Cassidy Arora, Gaurav Dickson, Kayle Lehmann, Christian
Published in
Molecules
Iron is an essential element in multiple biochemical pathways in humans and pathogens. As part of the innate immune response in local infection, iron availability is restricted locally in order to reduce overproduction of reactive oxygen species by the host and to attenuate bacterial growth. This physiological regulation represents the rationale fo...
Sekovanić, Sanja
Pfister, Joachim Bata, Roland Hubmann, Isabella Hörmann, Anton Amadeus Gsaller, Fabio Haas, Hubertus Decristoforo, Clemens
Published in
Journal of Fungi
Antifungal resistance of human fungal pathogens represents an increasing challenge in modern medicine. Short antimicrobial peptides (AMP) display a promising class of antifungals with a different mode of action, but lack target specificity and metabolic stability. In this study the hexapeptide PAF26 (Ac-dArg-dLys-dLys-dTrp-dPhe-dTrp-NH2) and the th...
Nodwell, Matthew B Britton, Robert
Published in
ACS infectious diseases
A solid-phase platform for the precise and sequential synthesis of enterobactin analogues is described. This chemistry unites the power of solid-phase peptide synthesis with the unique opportunities and applications offered by siderophore chemistry. Here, a series of hybrid enterobactin hydroxamate/catecholate (HEHC) analogues were synthesized usin...
Gunzer, Matthias Thornton, Christopher R. Beziere, Nicolas
Published in
Journal of Fungi
Invasive pulmonary aspergillosis (IPA) is a life-threatening infection of immunocompromised patients with Aspergillus fumigatus , a ubiquitous environmental mould. While there are numerous functioning antifungal therapies, their high cost, substantial side effects and fear of overt resistance development preclude permanent prophylactic medication o...
David, Sébastien R Geoffroy, Valérie A
Published in
Microorganisms
Asbestos, silicate minerals present in soil and used for building constructions for many years, are highly toxic due primarily to the presence of high concentrations of the transition metal iron. Microbial weathering of asbestos occurs through various alteration mechanisms. Siderophores, complex agents specialized in metal chelation, are common mec...
Southwell, James W Black, Conor M Duhme-Klair, Anne-Kathrin
Published in
ChemMedChem
The field of antibacterial siderophore conjugates, referred to as Trojan Horse antibacterials, has received increasing attention in recent years, driven by the rise of antimicrobial resistance. Trojan Horse antibacterials offer an opportunity to exploit the specific pathways present in bacteria for active iron uptake, potentially allowing the drugs...
Vander Elst, Niels Breyne, Koen Steenbrugge, Jonas Gibson, Amanda Jane Smith, David George Emslie Germon, Pierre Werling, Dirk Meyer, Evelyne
Iron is an essential nutrient for bacterial growth. Therefore, bacteria have evolved chelation mechanisms to acquire iron for their survival. Enterobactin, a chelator with high affinity for ferric iron, is secreted by Escherichia coli and contributes to its improved bacterial fitness. In this preliminary study, we evaluated enterobactin deficiency ...
de Souza, Aparecido Ferreira de Paula, Marcella Silva Lima, Raisa Melo Silva, Marielle Garcia de Curcio, Juliana Santana Pereira, Maristela de Almeida Soares, Célia Maria
Published in
Journal of Fungi
Paracoccidioides is a genus of thermodimorphic fungi that causes paracoccidioidomycosis. When in the host, the fungus undergoes several challenges, including iron deprivation imposed by nutritional immunity. In response to the iron deprivation triggered by the host, the fungus responds in a ternary manner using mechanisms of high affinity and speci...
