Nardo-Marino, Amina Petersen, Jesper Brewin, John N Birgens, Henrik Williams, Thomas N Kurtzhals, Jørgen A L Rees, David C Glenthøj, Andreas
Published in
British journal of haematology
The loss of red blood cell (RBC) deformability in sickle cell anaemia (SCA) is considered the primary factor responsible for episodes of acute pain and downstream progressive organ dysfunction. Oxygen gradient ektacytometry (Oxygenscan) is a recently commercialised functional assay that aims to describe the deformability of RBCs in SCA at differing...
Adeniyi, Olayemi Baptista, Rafael Bhowmick, Sumana Cookson, Alan Nash, Robert J Winters, Ana Shen, Jianying Mur, Luis A J
Published in
Journal of clinical medicine
Alchornea cordifolia Müll. Arg. (commonly known as Christmas Bush) has been used traditionally in Africa to treat sickle cell anaemia (a recessive disease, arising from the S haemoglobin (Hb) allele), but the active compounds are yet to be identified. Herein, we describe the use of sequential fractionation coupled with in vitro anti-sickling assays...
Nardo-Marino, Amina Braunstein, Thomas H. Petersen, Jesper Brewin, John N. Mottelson, Mathis N. Williams, Thomas N. Kurtzhals, Jørgen A. L. Rees, David C. Glenthøj, Andreas
Published in
Frontiers in Physiology
The spleen plays an important role in the body’s defence against bacterial infections. Measuring splenic function is of interest in multiple conditions, including sickle cell anaemia (SCA), where spleen injury occurs early in life. Unfortunately, there is no direct and simple way of measuring splenic function, and it is rarely assessed in clinical ...
Nardo-Marino, A Braunstein, TH Petersen, J Brewin, JN Mottelson, MN Williams, TN Kurtzhals, JAL Rees, DC Glenthøj, A
The spleen plays an important role in the body's defence against bacterial infections. Measuring splenic function is of interest in multiple conditions, including sickle cell anaemia (SCA), where spleen injury occurs early in life. Unfortunately, there is no direct and simple way of measuring splenic function, and it is rarely assessed in clinical ...
gentinetta;, thomas
People living with sickle cell disease (SCD) face intermittent acute pain episodes due to vaso-occlusion primarily treated palliatively with opioids. Hemolysis of sickle erythrocytes promotes release of heme, which activates inflammatory cell adhesion proteins on endothelial cells and circulating cells, promoting vaso-occlusion. In this study, plas...
Hammoudi, Nadjib Ceccaldi, Alexandre Haymann, Jean-Philippe Guedeney, Paul Nicolas-Jilwan, Fadila Zeitouni, Michel Montalescot, Gilles Lionnet, François Isnard, Richard Hatem, Stéphane N
...
Published in
European journal of clinical investigation
The underlying mechanisms of exercise intolerance in sickle cell anaemia (SCA) patients are complex and not yet completely understood. While latent heart failure at rest could be unmasked upon exercise, most previous studies assessed cardiac function at rest. We aimed to investigate exercise cardiovascular reserve as a potential contributor to exer...
Nardo-Marino, A Petersen, J Brewin, J Birgens, H Williams, T Kurtzhals, J Rees, D Glenthøj, A
The loss of red blood cell (RBC) deformability in sickle cell anaemia (SCA) is considered the primary factor responsible for episodes of acute pain and downstream progressive organ dysfunction. Oxygen gradient ektacytometry (Oxygenscan) is a recently commercialised functional assay that aims to describe the deformability of RBCs in SCA at differing...
Adebayo, Oyindamola Christiana Betukumesu, DieuMerci Kabasele Nkoy, Agathe Bikupe Adesoji, Oluyomi Modupe Ekulu, Pepe Mfutu Van den Heuvel, Lambertus P Levtchenko, Elena N Labarque, Veerle
Published in
British journal of haematology
Clinical and genetic factors have been reported as influencing the development of sickle cell nephropathy (SCN). However, such data remain limited in the paediatric population. In this cross-sectional study, we enrolled 361 sickle cell disease children from the Democratic Republic of Congo. Participants were genotyped for the beta (β)-globin gene, ...
Adebayo, Oyindamola Christiana; 134542; Betukumesu, DieuMerci Kabasele; Nkoy, Agathe Bikupe; Adesoji, Oluyomi Modupe; Ekulu, Pepe Mfutu; Van den Heuvel, Lambertus P; 59284; Levtchenko, Elena N; 55533; Labarque, Veerle; 41869;
Clinical and genetic factors have been reported as influencing the development of sickle cell nephropathy (SCN). However, such data remain limited in the paediatric population. In this cross-sectional study, we enrolled 361 sickle cell disease children from the Democratic Republic of Congo. Participants were genotyped for the beta (β)-globin gene, ...
Ware, Russell E Dertinger, Stephen D
Published in
British journal of haematology
Hydroxyurea (hydroxycarbamide) is approved for treating both children and adults with sickle cell anaemia (SCA). Fetal haemoglobin (HbF) induction is the primary treatment response, along with improved anaemia, reduced haemolysis, myelosuppression and decreased endothelial inflammation. Hydroxyurea has proven clinical efficacy for SCA - treatment s...
