Ma, Yijun Wang, Jun Tang, Chao Li, Wei Lv, Xuan Zhu, Suijun
Published in
Frontiers in Neurology
Background Interleukin-1 receptor-associated kinase 3 (IRAK3) modulates neuroinflammation. This study aimed to determine the prognostic role of serum IRAK3 in acute intracerebral hemorrhage (ICH). Methods In this prospective observational cohort study, 152 patients with supratentorial ICH, along with 63 healthy controls, were recruited. Serum IRAK3...
Chen, Yijing Zhou, Lijun Chen, Fang Chen, Zhongzhong Huang, Yichen Lv, Yiqing Wu, Min Lin, Xiaoling Xie, Hua
Published in
Frontiers in Pediatrics
Background CNV in KCTD13 has been identified to influence androgen receptor function via its changes in gene dosage, which might contribute to hypospadias. However, there is lack of population-level evidence to assess the contribution of KCTD13 CNV to hypospadias.Methods 349 isolated hypospadias patients were recruited and their genotyping was perf...
Ouyang, Shijia Peng, Xiaoyin Huang, Wenchen Bai, Jinli Wang, Hong Jin, Yuwei Jiao, Hui Wei, Maoti Ge, Xiushan Song, Fang
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Published in
Frontiers in Neurology
Background Biomarkers can be used to assess the severity of spinal muscular atrophy (5q SMA; SMA). Despite their potential, the relationship between biomarkers and clinical outcomes in SMA remains underexplored. This study aimed to assess the association among biomarkers, phenotypes, and motor milestones in Chinese patients diagnosed with SMA. Meth...
Yalcin, Nadir; van den Anker, John; Samiee-Zafarghandy, Samira; Allegaert, Karel; 46648;
INTRODUCTION: Assessment of drug-related adverse events is essential to fully understand the benefit-risk balance of any drug exposure, weighing efficacy versus safety. This is needed for both drug labeling and clinical decision-making. Assessment is based on seriousness, severity and causality, be it more difficult to apply in neonates. Adverse ev...
Ho, Hsi-En Arditi, Zoe Radigan, Lin Grishina, Galina Zhang, Lingdi Chun, Yoojin Lo, Tracy Wang, Julie Sicherer, Scott Bunyavanich, Supinda
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Published in
The Journal of allergy and clinical immunology
Reaction threshold and severity in food allergy are difficult to predict, and noninvasive predictors are lacking. We sought to determine the relationships between pre-challenge levels of peanut (PN)-specific antibodies in saliva and reaction threshold, severity, and organ-specific symptoms during PN allergic reactions. We measured PN-specific antib...
Idris, Zulkarnain Md Wahid, Wathiqah Seri Rakna, Mohd Ikhwan Mukmin Ghazali, Nuraffini Hassan, Noor Wanie Abdul Manap, Siti Nor Azreen Mohamed, Ahmad Imran Chuangchaiya, Sriwipa Mohd Kasri, Muhd Rafiq
Published in
Frontiers in Public Health
Introduction Anaemia remains a primary concern of public health in developing countries. Indigenous populations are a significant and frequently underreported group at risk for anaemia. This study aimed to assess the prevalence of anaemia and identify its determinants in the Temiar sub-ethnic indigenous Orang Asli (OA) community in Peninsular Malay...
Roshan, Gholamreza Arekhi, Saleh Bayganeh, Zainab Attia, Shady
peer reviewed / Increasing land surface temperature (LST) and urban heat island intensity (UHII) have been reported to be closely associated with a large number of environmental issues. Understanding LST and UHII rise in cities during heatwaves is crucial for implementing mitigation measures. This paper aims to explain these variations in response ...
Aalaie, Behnaz Sadeghi, Javad Mohammadi, Tanya Mohammadi, Babak
Published in
Modern rheumatology
To develop a clinical instrument to assess carpal tunnel syndrome (CTS) severity before electrodiagnostic testing. Data from 1037 patients with CTS (39.1% male) were included. The mean (SD) age was 58.0 (10.8) years. The severity of CTS was based on electrodiagnostic findings. We devised a composite index incorporating a pain numeric rating scale (...
Yun, Ji Hyun Chang, Euijin Bae, Seongman Jung, Jiwon Kim, Min Jae Chong, Yong Pil Kim, Sung-Han Choi, Sang-Ho Lee, Sang-Oh Kim, Yang Soo
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Published in
Microbiology Spectrum
In this study, we assessed the clinical and microbiological characteristics of heterogeneous vancomycin-intermediated Staphylococcus aureus (hVISA) bacteremia and identified risk factors for vancomycin treatment failure. We found that advanced age and severity of infection were independent risk factors for vancomycin treatment failure. On the other...
Cao, Fengsheng Zhang, Lu Zhao, Zhenwang Shen, Xiaofang Xiong, Jinsong Yang, Zean Gong, Baoxian Liu, Mingming Chen, Huabo Xiao, Hong
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Published in
Frontiers in Immunology
Introduction Acute respiratory distress syndrome (ARDS) is a major cause of death among critically ill patients in intensive care settings, underscoring the need to identify biomarkers capable of predicting ARDS patient clinical status and prognosis at an early time point. This study specifically sought to explore the utility and clinical relevance...
