Rosenblatt, Kathryn Walker, Keenan A Goodson, Carrie Olson, Elsa Maher, Dermot Brown, Charles H 4th Nyquist, Paul
Published in
Journal of intensive care medicine
Impaired cerebral autoregulation and cerebral hypoperfusion may play a critical role in the high morbidity and mortality in patients with sepsis-associated encephalopathy (SAE). Bedside assessment of cerebral autoregulation may help individualize hemodynamic targets that optimize brain perfusion. We hypothesize that near-infrared spectroscopy (NIRS...
Semler, Matthew W Janz, David R Casey, Jonathan D Self, Wesley H Rice, Todd W
Published in
Journal of intensive care medicine
The feasibility and clinical outcomes of conservative fluid management after sepsis resuscitation remain unknown. To evaluate the effect of a conservative fluid management protocol on fluid balance and intensive care unit (ICU)-free days among patients with sepsis. In a single-center phase II/III randomized trial, we enrolled adults with suspected ...
Lee, Chien-Chang Kwa, Andrea Lay Hoon Apisarnthanarak, Anucha Feng, Jia-Yih Gluck, Eric Howard Ito, Akihiro Karuniawati, Anis Periyasamy, Petrick Pratumvinit, Busadee Sharma, Jeetendra
...
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Introduction Recently, an expert consensus on optimal use of procalcitonin (PCT)-guided antibiotic stewardship was published focusing mainly on Europe and the United States. However, for Asia-Pacific countries, recommendations may need adaptation due to differences in types of infections, available resources and standard of clinical care. Methods P...
Fahmey, Sameh S Hodeib, Mahmoud Refaat, Khaled Mohammed, Walaa
Published in
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Background: Neonatal sepsis is an important cause of neonatal morbidity and mortality especially in developing countries. Cardiac dysfunction is a major complication of severe sepsis and occurs as a part of multiple organ failure.Objective: To asses right and left ventricular functions in neonates with sepsis using tissue Doppler imaging (TDI).Meth...
Wang, Yiwen Gong, Dandan Yao, Chuanxia Zheng, Feng Zhou, Tingting Cao, Qingxin Zhu, Xuhui Wang, Maorong Zhu, Jin
Published in
Molecular medicine reports
Previous studies have revealed that activation of the Toll‑like receptor 4 (TLR4)‑mediated proinflammatory signaling pathway plays an important role in acute inflammation, sepsis and chronic inflammatory disorders. Moreover, TLR4 significantly contributes to lipopolysaccharide (LPS)‑induced immune response. Thus, modulation of the TLR4 pathway is a...
Stahl, Klaus Busch, Markus Maschke, Sabine K Schneider, Andrea Manns, Michael P Fuge, Jan Wiesner, Olaf Meyer, Bernhard C Hoeper, Marius M Hinrichs, Jan B
...
Published in
Journal of intensive care medicine
To analyze demography, clinical signs, and survival of intensive care patients diagnosed with nonocclusive mesenteric ischemia (NOMI) and to evaluate the effect of a local intra-arterial prostaglandin therapy. Retrospective observational study screening 455 intensive care patients with acute arterial mesenteric perfusion disorder in a tertiary care...
Kelly, Barry Patlak, Johann Shaefi, Shahzad Boone, Dustin Mueller, Ariel Talmor, Daniel
Published in
Journal of intensive care medicine
To compare the discriminative value of the quick-sequential organ failure assessment score (qSOFA) to SOFA in a critically ill population, in which a microbial pathogen was isolated within 48 hours of admission to intensive care. Retrospective cohort study. Academic tertiary referral center from July 2008 to June 2017. Hospitalized patients admitte...
Kasugai, Daisuke Hirakawa, Akihiko Ozaki, Masuyuki Nishida, Kazuki Ikeda, Takao Takahashi, Kunihiko Matsui, Shigeyuki Uenishi, Norimichi
Published in
Journal of intensive care medicine
The management of refractory septic shock remains a major challenge in critical care and its early indicators are not fully understood. We hypothesized that the maximum norepinephrine dosage within 24 hours of intensive care unit (ICU) admission may be a useful indicator of early mortality in patients with septic shock. In this retrospective single...
Karki, Rajendra Sharma, Bhesh Raj Tuladhar, Shraddha Williams, Evan Peter Zalduondo, Lillian Samir, Parimal Zheng, Min Sundaram, Balamurugan Banoth, Balaji Malireddi, R. K. Subbarao
...
Published in
bioRxiv
The COVID-19 pandemic has caused significant morbidity and mortality. Currently, there is a critical shortage of proven treatment options and an urgent need to understand the pathogenesis of multi-organ failure and lung damage. Cytokine storm is associated with severe inflammation and organ damage during COVID-19. However, a detailed molecular path...
Almutary, Abdulaziz Althunayyan, Saqer Alenazi, Khaled Alqahtani, Abdulrahman Alotaibi, Badar Ahmed, Marwa Osman, Isam S Kakpuri, Adil Alanazi, Abdulaziz Arafat, Mohammed
...
Published in
Infection and Drug Resistance
Purpose We assessed the National Early Warning Score (NEWS) in emergency triage for predicting sepsis-related outcomes. Methods A retrospective chart review of all cases enrolled in the sepsis management protocol for a one-year duration. The protocol utilized the NEWS as a screening tool for sepsis in the triage area. Primary outcomes of interest w...
