Bajaj, Jasmohan S Garcia-Tsao, Guadalupe Biggins, Scott W Kamath, Patrick S Wong, Florence McGeorge, Sara Shaw, Jawaid Pearson, Meredith Chew, Micheal Fagan, Andrew
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Published in
Gut
Comorbid conditions are associated with poor prognosis in COVID-19. Registry data show that patients with cirrhosis may be at high risk. However, outcome comparisons among patients with cirrhosis+COVID-19 versus patients with COVID-19 alone and cirrhosis alone are lacking. The aim of this study was to perform these comparisons. A multicentre study ...
Choi, Hyung Jun Yun, Jun-Won Kim, Youn-Hee Kwon, Euna Hyon, Min-Kyong Kim, Ji Young Che, Jeong-Hwan Park, Jin-Sung Kim, Hyoung-Chin Ho Kim, Woo
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Published in
Drug and chemical toxicology
Sodium taurodeoxycholate (TDCA) has been investigated for various inflammatory disorders such as sepsis. We recently evaluated nonclinical safety profile of TDCA using rats infused intravenously. As a series of preclinical safety investigations, we further conducted toxicity studies with TDCA delivered to dogs via intravenous administration under G...
Liu, Vincent X Bhimarao, Meghana Greene, John D Manickam, Raj N Martinez, Adriana Schuler, Alejandro Barreda, Fernando Escobar, Gabriel J
Published in
Critical care explorations
To characterize the signs and symptoms of sepsis, compare them with those from simple infection and other emergent conditions and evaluate their association with hospital outcomes. A multicenter, retrospective cohort study of 408,377 patients hospitalized through the emergency department from 2012 to 2017 with sepsis, suspected infection, heart fai...
Liu, Xiaqing Lin, Zhengfang Xu, Yufeng
Published in
Journal of Inflammation (London, England)
Background This study was designed to investigate the role of Pellino1 in lung injury model of sepsis and its anti-inflammation mechanism. Method: C57BL/6 male mice (6–7 weeks old) and Pellino1−/− male mice were subjected to laparotomy followed by extracorporeal cecum mobilization and ligation. THP-1 cells were treated with 500 ng/ml of LPS for 4 h...
Creeden, Justin Fortune Imami, Ali Sajid Eby, Hunter M. Gillman, Cassidy Becker, Kathryn N. Reigle, Jim Andari, Elissar Pan, Zhixing K O’Donovan, Sinead M McCullumsmith, Robert E
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Published in
Biomedicine & Pharmacotherapy
Yang, Xingyue Ren, He Zhang, Hong Liu, Gengqi Jiang, Zhen Qiu, Qian Yu, Cui Murthy, Niren Zhao, Kun Lovell, Jonathan F
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Published in
ACS applied materials & interfaces
One potential approach to address the rising threat of antibiotic resistance is through novel formulations of established drugs. We designed antibiotic cross-linked micelles (ABC-micelles) by cross-linking the Pluronic F127 block copolymers with an antibiotic itself, via a novel one-pot synthesis in aqueous solution. ABC-micelles enhanced antibioti...
Pakyz, Amy L Orndahl, Christine M Johns, Alicia Harless, David W Morgan, Daniel J Bearman, Gonzalo Hohmann, Samuel F Stevens, Michael P
Published in
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
The Centers for Medicare and Medicaid Services (CMS) implemented a core measure sepsis (SEP-1) bundle in 2015. One element was initiation of broad-spectrum antibiotics within 3 hours of diagnosis. The policy has the potential to increase antibiotic use and Clostridioides difficile infection (CDI). We evaluated the impact of SEP-1 implementation on ...
Wegrzyn, Gracelene Walborn, Amanda Rondina, Matthew Fareed, Jawed Hoppensteadt, Debra
Published in
Clinical and Applied Thrombosis/Hemostasis
Sepsis-associated disseminated intravascular coagulation (DIC) is related to marked hemostatic changes such as transient thrombocytopenia secondary to the endogenous activation and consumption of platelets. This study measured markers of platelet function in 103 adult ICU patients with clinically established sepsis-associated DIC to determine the b...
Brown, Armand O Singh, Kavindra V Cruz, Melissa R Kaval, Karan Gautam Francisco, Liezl E Murray, Barbara E Garsin, Danielle A
Published in
The Journal of infectious diseases
Enterococcus faecalis is a significant cause of hospital-acquired bacteremia. Herein, the discovery is reported that cardiac microlesions form during severe bacteremic E. faecalis infection in mice. The cardiac microlesions were identical in appearance to those formed by Streptococcus pneumoniae during invasive pneumococcal disease. However, E. fae...
Giacobbe, Daniele Roberto Signori, Alessio Del Puente, Filippo Mora, Sara Carmisciano, Luca Briano, Federica Vena, Antonio Ball, Lorenzo Robba, Chiara Pelosi, Paolo
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Published in
Frontiers in Medicine
Sepsis is a major cause of death worldwide. Over the past years, prediction of clinically relevant events through machine learning models has gained particular attention. In the present perspective, we provide a brief, clinician-oriented vision on the following relevant aspects concerning the use of machine learning predictive models for the early ...