Rogne, Tormod Damås, Jan Kristian Flatby, Helene Marie Åsvold, Bjørn Olav DeWan, Andrew Thomas Solligård, Erik
Published in
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Bloodstream infection and sepsis are major causes of health loss worldwide, and it is important to identify patients at risk of developing and dying from these conditions. The single-nucleotide polymorphism most strongly associated with sepsis mortality is FER rs4957796. However, it is not known how this variant is associated with bloodstream infec...
Hamer, Davidson H Coffin, Susan E
Published in
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Zheng, Xiangtao Chen, Weiwei Gong, Fangchen Chen, Ying Chen, Erzhen
Published in
Frontiers in Immunology
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Recently was been found that pyroptosis is a unique form of proinflammatory programmed death, that is different from apoptosis. A growing number of studies have investigated pyroptosis and its relationship with sepsis, including the mechanis...
Insuela, Daniella Bianchi Reis Ferrero, Maximiliano Ruben Gonçalves-de-Albuquerque, Cassiano Felip... Chaves, Amanda da Silva da Silva, Adriano Yagho Oliveira Castro-Faria-Neto, Hugo Caire Simões, Rafael Loureiro Barja-Fidalgo, Thereza Christina Silva, Patricia Machado Rodrigues e Martins, Marco Aurélio
...
Published in
Frontiers in Immunology
Sepsis is one of the most common comorbidities observed in diabetic patients, associated with a deficient innate immune response. Recently, we have shown that glucagon possesses anti-inflammatory properties. In this study, we investigated if hyperglucagonemia triggered by diabetes might reduce the migration of neutrophils, increasing sepsis suscept...
Yang, Xu Haque, Anwarul Matsuzaki, Shigenobu Matsumoto, Tetsuya Nakamura, Shigeki
Published in
Frontiers in Microbiology
The emergence of multi-drug resistant Pseudomonas aeruginosa necessitates the search for treatment options other than antibiotic use. The use of bacteriophages is currently being considered as an alternative to antibiotics for the treatment of bacterial infections. A number of bacteriophages were introduced to treat pneumonia in past reports. Howev...
Cox, Dermot
Published in
Frontiers in Pharmacology
It is clear that COVID-19 is more than a pneumonia and is associated with a coagulopathy and multi-organ failure. While the use of anti-coagulants does reduce the incidence of pulmonary emboli, it does not help with survival. This suggests that the coagulopathy is more likely to be platelet-driven rather than thrombin-driven. There is significant e...
Wang, Min Wei, Jilou Shang, Futai Zang, Kui Zhang, Peng
Published in
Journal of biochemistry
Sepsis is an acute systemic infectious disease engendered by infectious factors, which can cause the dysfunction of multiple organs, including acute kidney injury (AKI). Recently, more and more researchers are focussing on long noncoding RNA (lncRNA) that is closely associated with the development and progression of various diseases; however, the r...
Wang, Zhen Liu, Menglin Ye, Di Ye, Jing Wang, Menglong Liu, Jianfang Xu, Yao Zhang, Jishou Zhao, Mengmeng Feng, Yongqi
...
Published in
Frontiers in Pharmacology
Cardiac dysfunction is a well-recognized complication of sepsis and is associated with the outcome and prognosis of septic patients. Evidence suggests that Il12a participates in the regulation of various cardiovascular diseases, including heart failure, hypertension and acute myocardial infarction. However, the effects of Il12a in sepsis-induced ca...
Krasselt, Marco Baerwald, Christoph Petros, Sirak Seifert, Olga
Published in
Journal of intensive care medicine
Patients with rheumatoid arthritis (RA) have a high risk of infections that may require intensive care unit (ICU) admission in case of resulting sepsis. Data regarding the mortality of these patients are very limited. This study investigated clinical characteristics and outcomes of patients with RA admitted to the ICU for sepsis and compared the re...
McNeal, Christina D Ryan, Clare A Berghaus, Londa J Credille, Brenton C Lo, Chih-Ping Fajt, Virginia R
Published in
Journal of veterinary pharmacology and therapeutics
Cephalosporin antimicrobials can be utilized for the treatment of sepsis in neonatal foals, particularly when an aminoglycoside is contraindicated. Some cephalosporins, however, are not utilized because of cost, sporadic availability, or uncertainty about efficacy. The plasma disposition of ceftazidime, a third-generation cephalosporin with a broad...
