Ordaz-Ramos, Alejandro Tellez-Jimenez, Olivia Vazquez-Santillan, Karla
Published in
Frontiers in Cell and Developmental Biology
Breast cancer stem cells (BCSCs) represent a distinct subpopulation of cells with the ability to self-renewal and differentiate into phenotypically diverse tumor cells. The involvement of CSC in treatment resistance and cancer recurrence has been well established. Numerous studies have provided compelling evidence that the self-renewal ability of c...
Liu, Ying Jiang, Leilei Song, Wenbo Wang, Chenxi Yu, Shiting Qiao, Juhui Wang, Xinran Jin, Chenrong Zhao, Daqing Bai, Xueyuan
...
Published in
Frontiers in Cell and Developmental Biology
Recent studies have demonstrated that stem cells have attracted much attention due to their special abilities of proliferation, differentiation and self-renewal, and are of great significance in regenerative medicine and anti-aging research. Hence, finding natural medicines that intervene the fate specification of stem cells has become a priority. ...
Ling, Bai Xu, Yunyang Qian, Siyuan Xiang, Ze Xuan, Shihai Wu, Jian
Published in
Frontiers in Cell and Developmental Biology
Hematopoietic stem cells (HSCs) are important for the hematopoietic system because they can self-renew to increase their number and differentiate into all the blood cells. At a steady state, most of the HSCs remain in quiescence to preserve their capacities and protect themselves from damage and exhaustive stress. However, when there are some emerg...
Le Minh, Giang Esquea, Emily M. Dhameliya, Tejsi T. Merzy, Jessica Lee, Mi-Hye Ball, Lauren E. Reginato, Mauricio J.
Published in
Frontiers in Oncology
Introduction Breast tumor development is regulated by a sub-population of breast cancer cells, termed cancer stem-like cells (CSC), which are capable of self-renewing and differentiating, and are involved in promoting breast cancer invasion, metastasis, drug resistance and relapse. CSCs are highly adaptable, capable of reprogramming their own metab...
Schaafsma, Paulien Kracht, Laura Baanstra, Mirjam Jellema-de Bruin, Anne L. Coppes, Robert P.
Published in
Frontiers in Molecular Biosciences
Human salivary gland organoids have opened tremendous possibilities for regenerative medicine in patients undergoing radiotherapy for the treatment of head and neck cancer. However, their clinical translation is greatly limited by the current use of Matrigel for organoid derivation and expansion. Here, we envisage that the use of a fully, synthetic...
Herzog, Alexandra E. Somayaji, Ritu Nör, Jacques E.
Published in
Frontiers in Oral Health
Head and neck cancers are composed of a diverse group of malignancies, many of which exhibit an unacceptably low patient survival, high morbidity and poor treatment outcomes. The cancer stem cell (CSC) hypothesis provides an explanation for the substantial patient morbidity associated with treatment resistance and the high frequency of tumor recurr...
Coronas, Valérie Arnault, Patricia Jégou, Jean-François Cousin, Laetitia Rabeony, Hanitriniaina Clarhaut, Sandrine Harnois, Thomas Lecron, Jean-Claude Morel, Franck
Mainly known for its role in immune defense and inflammation, interleukin 22 (IL-22) has emerged over the past decade as a cytokine involved in the adaptation of stem/progenitor cell activity for tissue homeostasis and repair. IL-22 is present in the brain, which harbors neural stem cells (NSC) in specific niches of which the ventricular-subventric...
Yokoyama, Akihiko
Published in
The FEBS journal
Homeostasis in the blood system is maintained by the balance between self-renewing stem cells and nonstem cells. To promote self-renewal, transcriptional regulators maintain epigenetic information during multiple rounds of cell division. Mutations in such transcriptional regulators cause aberrant self-renewal, leading to leukemia. MOZ, a histone ac...
Picerno, Angela Giannuzzi, Francesca Curci, Claudia De Palma, Giuseppe Di Chiano, Mariagiovanna Simone, Simona Franzin, Rossana Gallone, Anna Di Lorenzo, Vito Francesco Stasi, Alessandra
...
Published in
Stem cells (Dayton, Ohio)
The long non-coding RNAs (lncRNA) play an important role in several biological processes, including some renal diseases. Nevertheless, little is known about lncRNA that are expressed in the healthy kidneys and involved in renal cell homeostasis and development, and even less is known about lncRNA involved in the maintenance of human adult renal ste...
Ayaz, Gamze Yan, Hualong Malik, Navdeep Huang, Jing
Published in
Stem cells (Dayton, Ohio)
The TP53 gene is unarguably one of the most studied human genes. Its encoded protein, p53, is a tumor suppressor and is often called the "guardian of the genome" due to its pivotal role in maintaining genome stability. Historically, most studies of p53 have focused on its roles in somatic cells and tissues, but in the last 2 decades, its functions ...
