Li, Jing Cheng, Ping Li, Shoufeng Zhao, Pengfei Han, Bing Ren, Xiaoyuan Zhong, Julia Li Lloyd, Matthew D Pourzand, Charareh Holmgren, Arne
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Published in
Antioxidants & redox signaling
Aims: Drug-induced liver injury, especially acetaminophen (APAP)-induced liver injury, is a leading cause of liver failure worldwide. Mouse models were used to evaluate the effect of microelement selenium levels on the cellular redox environment and consequent hepatotoxicity of APAP. Results: APAP treatment affected mouse liver selenoprotein thiore...
Okunade, Kehinde S Olowoselu, Olusola F John-Olabode, Sarah Hassan, Basirat O Akinsola, Oluwatosin J Nwogu, Chidinma M Ugwu, Aloy O Moses, Olusanjo E Rabiu, Kabiru A Ajepe, Adegbenga
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Published in
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
To examine the effects of selenium supplementation on pregnancy outcomes and disease progression among HIV-infected pregnant women in Lagos. A randomized, placebo-controlled trial conducted among HIV-positive pregnant women between September 2018 and August 2019. At enrollment, 90 women were randomly assigned into each treatment arm to receive eith...
Groth, Sabrina Budke, Christoph Weber, Timo Neugart, Susanne Brockmann, Sven Holz, Martina Sawadski, Bao Chau Daum, Diemo Rohn, Sascha
Notable parts of the population in Europe suffer from allergies towards apples. To address this health problem, the analysis of the interactions of relevant allergens with other substances such as phenolic compounds is of particular importance. The aim of this study was to evaluate the correlations between the total phenolic content (TPC), polyphen...
Lin, Kaiwen Xie, Boming Wang, Zhenfeng Yin, Qingwu Wang, Yuehui Duan, Chunhui Huang, Fei Cao, Yong
Published in
Frontiers in Chemistry
An electron acceptor with a truxene core and ring-fusion perylene diimide (PDI) tripolymer annulated by selenium (Se) branch, named as FTr-3PDI-Se, is designed and synthesized. FTr-3PDI-Se exhibits large conjugated planar conformation, strong absorption spectra in the regions of 300–400 and 450–550 nm, the deep HOMO energy level of 6.10 eV, and hig...
Erol, Seyit Ahmet Polat, Naci Akdas, Sevginur Aribal Ayral, Pelin Anuk, Ali Taner Ozden Tokalioglu, Eda Goncu Ayhan, Şule Kesikli, Burcu Ceylan, Merve Nur Tanacan, Atakan
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Published in
Journal of medical virology
Adequate maternal selenium level is essential for immune response and healthy pregnancy. This study aimed to shed light on the selenium status of pregnant women with COVID-19 and the effects of potential deficiency in serum selenium levels. Totally 141 pregnant women, 71 of them were COVID-19 patients, in different trimesters were included in the s...
Bizerea-Moga, Teofana Otilia Pitulice, Laura Bizerea-Spiridon, Otilia Moga, Tudor Voicu
Published in
Nutrients
Selenium, residing in a series of selenoproteins, plays an important role in both female and male reproductive function. Of particular significance for reproduction is the antioxidant glutathione peroxidase (GPx), a main selenoenzyme, whose level is regulated by the availability of Se in the body. We hypothesized that changes in Se status, closely ...
Perfileva, Alla I Nozhkina, Olga A Ganenko, Tatjana V Graskova, Irina A Sukhov, Boris G Artem'ev, Alexander V Trofimov, Boris A Krutovsky, Konstantin V
Published in
International journal of molecular sciences
The paper presents a study of the effect of chemically synthesized selenium nanocomposites (Se NCs) in natural polymer matrices arabinogalactan (AG) and starch (ST) on the viability of the potato ring rot pathogen Clavibacter sepedonicus (Cms), potato plants in vitro, and the soil bacterium Rhodococcus erythropolis. It was found that the studied Se...
Marcello, Elena Maqbool, Muhammad Nigmatullin, Rinat Cresswell, Mark Jackson, Philip R. Basnett, Pooja Knowles, Jonathan C. Boccaccini, Aldo R. Roy, Ipsita
Published in
Frontiers in Bioengineering and Biotechnology
Due to the threat posed by the rapid growth in the resistance of microbial species to antibiotics, there is an urgent need to develop novel materials for biomedical applications capable of providing antibacterial properties without the use of such drugs. Bone healing represents one of the applications with the highest risk of postoperative infectio...
Huang, Min-Fu N. Luis, José A. S. Silva, Alison P. da Rocha, Juliana C. Lima, Tatjana K. S. Scotti, Marcus T. Scotti, Luciana Oliveira, Rafael F. de Souza, Helivaldo D. S. Athayde-Filho, Petrônio F. de
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This study describes a virtual screening performed for two series of selenides (28 compounds), derived from N-phenylacetamides chlorides and 7-chloro-quinoline, to determine their potential for leishmanicidal activity against Leishmania amazonensis and Leishmania donovani. Seven compounds were predicted as potential leishmanicides; therefore, they ...
Lemos, Briana B Motta, Ketlyn P da Paltian, Jaini J Reis, Angélica S Blödorn, Gustavo B Soares, Mauro P Alves, Diego Luchese, Cristiane Wilhelm, Ethel A
Published in
Canadian journal of physiology and pharmacology
There is an increasing incidence of hepatotoxicity induced by oxaliplatin (OXA); therefore, researchers' attention has been drawn to therapeutic alternatives that may decrease OXA-induced hepatotoxicity. Studies indicate that oxidative stress plays a major role in OXA-induced liver injury. As several pharmacological effects of 7-chloro-4-(phenylsel...
