Published in Pest management science
To guarantee sustainability and progress, the agrochemical industry is faced with several major challenges. Currently, loss of active ingredients due to consumer perception, changing grower needs and ever-changing regulatory requirements is far higher than the number being introduced into the market. Therefore, there is a need to develop new produc...
Published in Inorganic Materials
AbstractWe develop a method on the basis of high-performance liquid phase chromatography–mass spectrometry (HPLC-MS) for determination of triterpene glycosides in ginseng extracts. In contrast to procedures based on HPLC with ultraviolet detection (HPLC-UV), commonly used for extract standardization, superior selectivity afforded by the developed m...
Published in Russian Chemical Bulletin
The sorption of lead by an impregnated type sorbent based on the phosphorylpodand, 1,8-bis[2-(diphenylphosphorylmethyl)phenoxy]-3,6-dioxaoctane, was studied. Sorption isotherms were plotted, as well as the data on kinetics, selectivity, and dynamics of sorption were obtained. The phosphorylpodand-based sorbent attains the sorption equilibrium of le...
Published in International journal of molecular sciences
The correlation between dysfunction in the glutamatergic system and neuropsychiatric disorders, including schizophrenia and autism spectrum disorder, is undisputed. Both disorders are associated with molecular and ultrastructural alterations that affect synaptic plasticity and thus the molecular and physiological basis of learning and memory. Alter...
Published in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry
A molecularly imprinted polymer-modified potentiometric histamine (HIS) sensor was prepared and used for quantitative determination of HIS in bovine serum. The calibration curve using the potential responses measured in 1 × 10-3 mol L-1 phosphate buffer (pH 7.4) showed good linearity in the HIS concentration range of 3 × 10-4 to 1 × 10-2 mol L-1 (r...
Published in ChemSusChem
CO2 electroreduction has gained significant interest. However, fabricating cost-effective nonprecious-metal electrocatalysts that can selectively convert CO2 to a specific product remains highly challenging. Herein, Pb-based materials consisting of Pb0 and PbO confined in ordered mesoporous carbon (OMC) (Pb/[email protected]) were constructed for CO2 electro...
This work proposes a spectrofluorometric method for the determination of total antioxidant capacity (CAO) in beverage samples, based on inhibition of thiochrome formation (λex = 370 nm, λem = 440 nm); a product of thiamine (vitamin B1) oxidation from K3Fe(CN)6. In the development of the method, gallic acid (GA) was used as a reference, and inhibiti...
Published in Journal of enzyme inhibition and medicinal chemistry
The selectivity for a specific human Carbonic Anhydrase (hCA) isoform is an important property a hCA inhibitor (CAI) should be endowed with, in order to constitute a valuable therapeutic tool for the treatment of a desired pathology. In this context, we developed a chemoinformatic platform that allows the analysis of the structure and selectivity p...
Published in Immunological medicine
The treatment of rheumatoid arthritis has changed dramatically over the last two decades since the development of biological disease-modifying anti-rheumatic drugs (bDMARDs). Moreover, Janus kinase (JAK) inhibitors became available in 2013. JAK inhibitors are low-molecular-weight compounds, which exert anti-rheumatic effects by suppressing the acti...
Published in Journal of enzyme inhibition and medicinal chemistry
Abnormal alterations in the expression and biological function of retinoid X receptor alpha (RXRα) have a key role in the development of cancer. Potential modulators of RXRα as anticancer agents are explored in growing numbers of studies. A series of (4/3-(pyrimidin-2-ylamino)benzoyl)hydrazine-1-carboxamide/carbothioamide derivatives are synthesise...
