Ye, Minsook Lee, SunYoung Yu, Hyo Jeong Kim, Kyu-Ri Park, Hyun-Jung Kang, In-Cheol Kang, Soon Ah Chung, Young-Shin Shim, Insop
Published in
International journal of molecular sciences
Glycine max Merr. (GM) is a functional food that provides many beneficial phytochemicals. However, scientific evidence of its antidepressive and sedative activities is scarce. The present study was designed to investigate the antidepressive and calmative effects of GM and its biologically active compound, genistein (GE), using electroencephalograph...
Bhuiya, N M Mahmudul Alam Hossen, Forman Islam, Monirul Hasan, Moynul
Published in
Turkish journal of pharmaceutical sciences
Gomphandra tetrandra (Wall.) Sleumer (leaves) belonging to the family Stemonuraceae was investigated for preliminary phytochemical screening and evaluating their pharmacological activities in various pharmacological models. The crude methanolic extract was screened with different chemical reagents for the qualitative detection of different phytoche...
Rakhshandeh, Hassan Rashidi, Roghayeh Vahedi, Mohammad Mahdi Khorrami, Mohammad Bagher Abbassian, Hassan Forouzanfar, Fatemeh
Published in
Recent patents on food, nutrition & agriculture
Sleep disorders are among the most common psychiatric and medical conditions. Herbal medicine appears to be effective in the treatment of sleep disorders which have been valued by many of publications and patents. The present study aimed at investigating the hypnotic activity of the hydro-alcoholic extract of Capparis spinosa (HAE) in mice. Three d...
Mikail, Hudu Garba Akumka, David Dezi Adamu, Mohammed Zaifada, Aishatu Ummi
Published in
Veterinary World
Background and Aim: Sedative drugs mostly cause dose-dependent depression of the central nervous system which results in hypnosis and anesthesia possibly; however, these agents are associated with some side effects ranging respiratory, digestive, immune system dysfunctions, tolerance, cognitive function deterioration, and physical dependence; hence...
Yuan, Mingxing Jiang, Li-juan Cheng, Chao Wang, Yujun Li, Ying Yin, Shufan
Published in
Chemistry of Natural Compounds
A series of helicid derivatives with benzyl protection of the hydroxyl group at allopyranosyloxy was synthesized and evaluated for sedative-hypnotic activity. The structures of the new compounds were characterized by 1H NMR, IR, and HR-MS spectra. The sedative-hypnotic activities of the target compounds were evaluated using the spontaneous locomoto...
Zheng, Lei Yin, Xiu Juan Yang, Cong Ling Li, Ying Yin, Shu Fan
Published in
Chemistry of Natural Compounds
Reactions of natural helicid with a number of 1,3-dicarbonyl compounds or β-ketoester in the presence of ammonium acetate or 1-naphthylamine gave a series of helicid derivatives containing a 1,4-dihydropyridine fragment (2a–2h). Eight novel helicid derivatives were structurally confirmed by IR, 1H NMR, 13C NMR, and HR-MS spectroscopy and evaluated ...
Yang, Congling Lv, Shiming Li, Ying Yin, Shufan
Published in
Chemistry of Natural Compounds
Under solvent-free conditions, syntheses of 2-aryl-4-(4-β-D-allopyranosyloxyphenyl)-4,6,7,8tetrahydroquinolin-5(1H)-one derivatives were carried out from chalcone (2a–2e), cyclohexane-1,3-dione (3), and NH4OAc in excellent yield without using any catalysts. The structure of the new compounds were characterized by 1H NMR, IR, and HR-MS spectroscopy....
Ling Luo, Hua Yang, Wei Li, Ying Fan Yin, Shu
Published in
Chemistry of Natural Compounds
A series of novel helicid derivatives containing 3,4-dihydropyrimidin-2(1H)-one and 3,4-dihydropyrimidine2(1H)-thione moiety (3a–3f and 4a–4f) were synthesized starting from helicid. The structure of the new compounds were characterized by 1H NMR, IR and HR-MS spectra. The sedative-hypnotic activities of the target compounds were evaluated using th...
