Brown, James William L Chowdhury, Azmain Kanber, Baris Prados Carrasco, Ferran Eshaghi, Arman Sudre, Carole H Pardini, Matteo Samson, Rebecca S van de Pavert, Steven Hp Wheeler-Kingshott, Claudia Gandini
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Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
In relapse-onset multiple sclerosis (MS), tissue abnormality - as assessed with magnetisation transfer ratio (MTR) imaging - is greater in the outer cortical and inner periventricular layers. The cause of this remains unknown but meningeal inflammation has been implicated, particularly lymphoid follicles, which are seen in secondary progressive (SP...
Ziemssen, Tjalf Piani-Meier, Daniela Bennett, Bryan Johnson, Chloe Tinsley, Katie Trigg, Andrew Hach, Thomas Dahlke, Frank Tomic, Davorka Tolley, Chloe
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Published in
Journal of Medical Internet Research
Background Defining the transition from relapsing-remitting multiple sclerosis (RRMS) to secondary progressive multiple sclerosis (SPMS) can be challenging and delayed. A digital tool (MSProDiscuss) was developed to facilitate physician-patient discussion in evaluating early, subtle signs of multiple sclerosis (MS) disease progression representing ...
Couloume, Laura Barbin, Laetitia Leray, Emmanuelle Wiertlewski, Sandrine Le Page, Emmanuelle Kerbrat, Anne Ory, Solenn Le Port, Damien Edan, Gilles Laplaud, David-Axel
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Background - A recent controlled trial suggested that high-dose biotin supplementation reverses disability progression in patients with progressive multiple sclerosis. Objective - To analyze the impact of high-dose biotin in routine clinical practice on disability progression at 12 months. Methods - Progressive multiple sclerosis patients who start...
Tam, Roger
Published in
Multiple Sclerosis Journal - Experimental, Translational and Clinical
Background Enhanced prediction of progression in secondary progressive multiple sclerosis (SPMS) could improve clinical trial design. Machine learning (ML) algorithms are methods for training predictive models with minimal human intervention. Objective To evaluate individual and ensemble model performance built using decision tree (DT)-based algori...
Solari, Alessandra Giovannetti, Ambra Mara Giordano, Andrea Tortorella, Carla Torri Clerici, Valentina Brichetto, Giampaolo Granella, Franco Lugaresi, Alessandra Patti, Francesco Salvetti, Marco
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Published in
Frontiers in neurology
Background: Few studies have investigated the experiences of patients around the conversion to secondary progressive multiple sclerosis (SPMS). ManTra is a mixed-method, co-production research project conducted in Italy and Germany to develop an intervention for newly-diagnosed SPMS patients. In previous project actions, we identified the needs and...
Nathan, Janak Khedekar Kale, Dhanashri Naik, Vidula D Thakker, Forum Bailur, Sonal
Published in
Cureus
A 60-year-old man presented with a history of an acute episode of mono-ocular involvement and several acute spinal cord episodes from 1988 to 1991. Multiple MRIs of the spinal cord and brain and cerebrospinal fluid analysis were consistent with a clinical diagnosis of multiple sclerosis (MS). Following this, there was a quiescent period of four to ...
Romme Christensen, Jeppe Komori, Mika von Essen, Marina Rode Ratzer, Rikke Börnsen, Lars Bielekova, Bibi Sellebjerg, Finn
Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
Development of treatments for progressive multiple sclerosis (MS) is challenged by the lack of sensitive and treatment-responsive biomarkers of intrathecal inflammation. To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relati...
Kadowaki, Atsushi Saga, Ryoko Lin, Youwei Sato, Wakiro Yamamura, Takashi
Published in
Brain
The mechanism underlying the progression of relapsing-remitting multiple sclerosis to secondary progressive multiple sclerosis (SPMS), characterized by accumulating fixed disability, is yet to be fully understood. Although alterations in the gut microbiota have recently been highlighted in multiple sclerosis pathogenesis, the mechanism linking the ...
Iacobaeus, Ellen Douagi, Iyadh Jitschin, Regina Marcusson-Ståhl, Maritha Andrén, Anton Törnqvist Gavin, Caroline Lefsihane, Katia Davies, Lindsay C Mougiakakos, Dimitrios Kadri, Nadir
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Published in
Immunology and cell biology
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system involving dysregulated encephalitogenic T cells. Myeloid-derived suppressor cells (MDSCs) have been recognized for their important function in regulating T-cell responses. Recent studies have indicated a role for MDSCs in autoimmune diseases, but their significanc...
Kappos, Ludwig Butzkueven, Helmut Wiendl, Heinz Spelman, Timothy Pellegrini, Fabio Chen, Yi Dong, Qunming Koendgen, Harold Belachew, Shibeshih Trojano, Maria
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Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
Confirmed Expanded Disability Status Scale (EDSS) progression occurring after a fixed-study entry baseline is a common measure of disability increase in relapsing-remitting multiple sclerosis (RRMS) studies but may not detect all disability progression events, especially those unrelated to overt relapses. To evaluate possible measures of disability...
