Couloume, Laura Barbin, Laetitia Leray, Emmanuelle Wiertlewski, Sandrine Le Page, Emmanuelle Kerbrat, Anne Ory, Solenn Le Port, Damien Edan, Gilles Laplaud, David-Axel
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Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
A recent controlled trial suggested that high-dose biotin supplementation reverses disability progression in patients with progressive multiple sclerosis. To analyze the impact of high-dose biotin in routine clinical practice on disability progression at 12 months. Progressive multiple sclerosis patients who started high-dose biotin at Nantes or Re...
Fyndanis, Valantis Messinis, Lambros Nasios, Grigorios Dardiotis, Efthimios Martzoukou, Maria Pitopoulou, Maria Ntoskou, Aikaterini Malefaki, Sonia
Published in
Frontiers in Psychology
Background A recent systematic review found that language deficits are not very common in individuals with multiple sclerosis (MS). However, there are significant gaps in our knowledge about language abilities in MS. For instance, morphosyntactic production has not been explored adequately thus far. This study investigated verb-related morphosyntac...
Takewaki, Daiki Suda, Wataru Sato, Wakiro Takayasu, Lena Kumar, Naveen Kimura, Kimitoshi Kaga, Naoko Mizuno, Toshiki Miyake, Sachiko Hattori, Masahira
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Published in
Proceedings of the National Academy of Sciences of the United States of America
Multiple sclerosis (MS), an autoimmune disease of the central nervous system, generally starts as the relapsing remitting form (RRMS), but often shifts into secondary progressive MS (SPMS). SPMS represents a more advanced stage of MS, characterized by accumulating disabilities and refractoriness to medications. The aim of this study was to clarify ...
Giovannetti, Ambra Mara Barabasch, Anna Giordano, Andrea Quintas, Rui Barello, Serena Graffigna, Guendalina Alfieri, Sara Schiffmann, Insa Muche-Borowski, Cathleen Borreani, Claudia
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Published in
Frontiers in Neurology
Background: ManTra is a mixed-methods, co-production research project for developing an intervention (resource) for people with newly diagnosed secondary progressive multiple sclerosis (pwSPMS) in Italy and Germany. In previous project actions, six resources were outlined, meeting the needs prioritized by pwSPMS. Aims: This study aims to achieve mu...
Ziemssen, Tjalf Hoffmann, Olaf Klotz, Luisa Schreiber, Herbert Weber, Martin S Rauser, Benedict
Published in
JMIR research protocols
A high proportion of patients with relapsing remitting multiple sclerosis convert to secondary progressive multiple sclerosis (SPMS) characterized by irreversibly progressing disability and cognitive decline. Siponimod (Mayzent), a selective sphingosine-1-phosphate receptor modulator, was recently approved by the European Medicines Agency for the t...
Brown, James William L Chowdhury, Azmain Kanber, Baris Prados Carrasco, Ferran Eshaghi, Arman Sudre, Carole H Pardini, Matteo Samson, Rebecca S van de Pavert, Steven Hp Wheeler-Kingshott, Claudia Gandini
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Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
In relapse-onset multiple sclerosis (MS), tissue abnormality - as assessed with magnetisation transfer ratio (MTR) imaging - is greater in the outer cortical and inner periventricular layers. The cause of this remains unknown but meningeal inflammation has been implicated, particularly lymphoid follicles, which are seen in secondary progressive (SP...
Ziemssen, Tjalf Piani-Meier, Daniela Bennett, Bryan Johnson, Chloe Tinsley, Katie Trigg, Andrew Hach, Thomas Dahlke, Frank Tomic, Davorka Tolley, Chloe
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Published in
Journal of medical Internet research
Defining the transition from relapsing-remitting multiple sclerosis (RRMS) to secondary progressive multiple sclerosis (SPMS) can be challenging and delayed. A digital tool (MSProDiscuss) was developed to facilitate physician-patient discussion in evaluating early, subtle signs of multiple sclerosis (MS) disease progression representing this transi...
Law, Marco Tk Traboulsee, Anthony L Li, David Kb Carruthers, Robert L Freedman, Mark S Kolind, Shanon H Tam, Roger
Published in
Multiple sclerosis journal - experimental, translational and clinical
Enhanced prediction of progression in secondary progressive multiple sclerosis (SPMS) could improve clinical trial design. Machine learning (ML) algorithms are methods for training predictive models with minimal human intervention. To evaluate individual and ensemble model performance built using decision tree (DT)-based algorithms compared to logi...
Solari, Alessandra Giovannetti, Ambra Mara Giordano, Andrea Tortorella, Carla Torri Clerici, Valentina Brichetto, Giampaolo Granella, Franco Lugaresi, Alessandra Patti, Francesco Salvetti, Marco
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Published in
Frontiers in neurology
Background: Few studies have investigated the experiences of patients around the conversion to secondary progressive multiple sclerosis (SPMS). ManTra is a mixed-method, co-production research project conducted in Italy and Germany to develop an intervention for newly-diagnosed SPMS patients. In previous project actions, we identified the needs and...
Nathan, Janak Khedekar Kale, Dhanashri Naik, Vidula D Thakker, Forum Bailur, Sonal
Published in
Cureus
A 60-year-old man presented with a history of an acute episode of mono-ocular involvement and several acute spinal cord episodes from 1988 to 1991. Multiple MRIs of the spinal cord and brain and cerebrospinal fluid analysis were consistent with a clinical diagnosis of multiple sclerosis (MS). Following this, there was a quiescent period of four to ...
