Nonami, Atsushi Matsuo, Ryu Funakoshi, Kouta Nakayama, Tomohiro Goto, Shigenori Iino, Tadafumi Takaishi, Shigeo Mizuno, Shinichi Akashi, Koichi Eto, Masatoshi
...
Published in
Cytotherapy
This prospective clinical study aimed to determine the efficacy and prognostic factors of adoptive activated αβT lymphocyte immunotherapy for various refractory cancers. The primary endpoint was overall survival (OS), and the secondary endpoint was radiological response. The authors treated 96 patients. Activated αβT lymphocytes were infused every ...
Chen, Qingchuan Liu, Zhouyang Tan, Yuen Pan, Siwei An, Wen Xu, Huimian
Published in
Cancer medicine
Most human genes have diverse transcript isoforms, which mainly arise from alternative cleavage and polyadenylation (APA) at 3' ends. N7-methylguanosine (m7 G) is also an essential epigenetic modification at the 5' end. However, the contribution of these two RNA modifications to the development, prognosis, regulation mechanisms, and drug sensitivit...
Jin, Xiaxia Hu, Lingling Fang, Meidan Zheng, Qiaofei Yuan, Yuan Lu, Guoguang Li, Tao
Published in
Frontiers in Oncology
Background Malignant pericardial effusion (MPE) is a serious complication in patients with advanced malignant tumors, which indicates a poor prognosis. However, its clinical manifestations lack specificity, making it challenging to distinguish MPE from benign pericardial effusion (BPE). The aim of this study was to develop and validate a scoring sy...
Pekar-Zlotin, Marina Maymon, Ron Eliassi Revivo, Perry Ezratty, Jody Melcer, Yaakov Kugler, Nadav Jauniaux, Eric
Published in
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Placenta Accreta Spectrum (PAS) disorders have become a major iatrogenic obstetric complication worldwide. Data on the accuracy of ultrasound examination diagnosis are limited by incomplete confirmation and variability in the description of the different grades of PAS at delivery. The aim of this study was to compare our prenatal routine sonographi...
Zhou, Xiaochen Li, Xuwen Fu, Bin Liu, Weipeng Zhang, Cheng Xia, Yu Gong, Honghan Zhu, Lingyan Lei, Enjun Kaplan, Joshua
...
Published in
Frontiers in Endocrinology
Objectives To propose an original and standardized scoring system to quantify the functional and anatomical characteristics of adrenal tumor. Materials and methods Four groups of consecutive adrenalectomies (n = 458) with heterogeneity in tumor characteristics and surgical approaches, including 212 laparoscopic cases (Group 1) and 105 robotic cases...
Hu, Shiwei Chen, Dan Xu, Xiaofei Zhang, Lan Wang, Shengjie Jin, Keyi Zheng, Yan Zhu, Xiaoqiong Jin, Jie Huang, Jian
...
Published in
Cancers
A proportion of patients with somatic variants show resistance or intolerance to TKI therapy, indicating additional mutations other than BCR∷ABL1 may lead to TKI treatment failure or disease progression. We retrospectively evaluated 151 CML patients receiving TKI therapy and performed next-generation sequencing (NGS) analysis of 22 CML patients at ...
Recher, Morgan Leteurtre, Stéphane Canon, Valentine Baudelet, Jean Benoit Lockhart, Marguerite Hubert, Hervé
Published in
Frontiers in Pediatrics
Severity and organ dysfunction (OD) scores are increasingly used in pediatric intensive care units (PICU). Therefore, this review aims to provide 1/ an updated state-of-the-art of severity scoring systems and OD scores in pediatric critical care, which explains 2/ the performance measurement tools and the significance of each tool in clinical pract...
Zhang, Jianguo Zhao, Daguo Hu, Jianhui Huang, Xing Gu, Qingqing Tao, Zhimin
Published in
Frontiers in Public Health
Background Presently, the omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dominates amid the coronavirus disease 2019 (COVID-19) pandemic, but its clinical characteristics with intrinsic severity and organ tropism remain understudied. Methods We reported 1,001 mild COVID-19 patients that were infected with the omicro...
Parker, Victoria L Winter, Matthew C Tidy, John A Hancock, Barry W Palmer, Julia E Sarwar, Naveed Kaur, Baljeet McDonald, Katie Aguiar, Xianne Singh, Kamaljit
...
Published in
International journal of cancer
Gestational trophoblastic neoplasia (GTN) patients are treated according to the eight-variable International Federation of Gynaecology and Obstetrics (FIGO) scoring system, that aims to predict first-line single-agent chemotherapy resistance. FIGO is imperfect with one-third of low-risk patients developing disease resistance to first-line single-ag...
Contro, Elena Cattani, Laura Balducci, Anna Prandstraller, Daniela Perolo, Antonella Larcher, Laura Reggiani, Maria Letizia Bacchi- Farina, Antonio Donti, Andrea Gargiulo, Gaetano Domenico
...
Published in
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Coarctation of the aorta (CoA) is common and can lead to neonatal emergency. Despite its burden, antenatal detection of this condition remains inaccurate. To evaluate the diagnostic performance of fetal echocardiography and to design a scoring system for risk stratification of CoA in suspected cases. A retrospective cohort study. S. Orsola Hospital...
