Chistyakov, Dmitry V. Astakhova, Alina A. Goriainov, Sergei V. Sergeeva, Marina G.
Published in
International Journal of Molecular Sciences
Neuroinflammation is a key process of many neurodegenerative diseases and other brain disturbances, and astrocytes play an essential role in neuroinflammation. Therefore, the regulation of astrocyte responses for inflammatory stimuli, using small molecules, is a potential therapeutic strategy. We investigated the potency of peroxisome proliferator-...
Hong, Hwanhee Wang, Chenguang Rosner, Gary L
Published in
Clinical trials (London, England)
Regulatory approval of a drug or device involves an assessment of not only the benefits but also the risks of adverse events associated with the therapeutic agent. Although randomized controlled trials (RCTs) are the gold standard for evaluating effectiveness, the number of treated patients in a single RCT may not be enough to detect a rare but ser...
Xu, Lingyan Ma, Xinran Verma, Narendra Perie, Luce Pendse, Jay Shamloo, Sama Marie Josephson, Anne Wang, Dongmei Qiu, Jin Guo, Mingwei
...
Published in
Aging Cell
In this manuscript, we show that chronic use of low doses of antidiabetic drugs that target the nuclear receptor PPARgamma preserves metabolic organ function and cognitive abilities and decreases depression‐ and anxiety‐like symptoms. Through functional, histological, and molecular analyses, we demonstrated that treated mice have improved adipose t...
Kumar, Navneet Gahlawat, Anuj Kumar, Rajaram Naresh Singh, Yash Pal Modi, Gyan Garg, Prabha
Published in
Journal of biomolecular structure & dynamics
Alzheimer's disease (AD) is one of the most familiar multifactorial and complex neurodegenerative disorders characterized by loss of cholinergic neurons in the brain. The various attempts for drug development to treat AD have been hampered by largely unsuccessful clinical trials in the last two decades. Developing a new drug from scratch takes enor...
Zhang, Shun Zhuang, Lingling Liu, Qian Yu, Xiaolin Min, Qinghua Chen, Minjie Chen, Qi
Published in
Molecular Medicine Reports
Endometriosis is closely associated with inflammatory reactions and angiogenesis. Whether PPARγ is a target for the treatment of endometriosis remains unknown. The present study was designed to investigate the impact of a PPARγ agonist (rosiglitazone, RSG) on endometriosis in a rat model and to identify the underlying mechanism. The endometriosis m...
Almeida, Maria Kim, Ha-Neui Han, Li Zhou, Daohong Thostenson, Jeff Porter, Ryan M Ambrogini, Elena Manolagas, Stavros C Jilka, Robert L
Published in
Aging cell
Marrow adipocytes and osteoblasts differentiate from common mesenchymal progenitors in a mutually exclusive manner, and diversion of these progenitors toward adipocytes in old age has been proposed to account for the decline in osteoblasts and the development of involutional osteoporosis. This idea has been supported by evidence that thiazolidinedi...
Veettil, Raveendran Arkiath Fernandez, Cornelius James Jacob, Koshy
Published in
Current drug safety
Type 2 diabetes mellitus (T2DM) is characterized by a progressive beta cell dysfunction in the setting of peripheral insulin resistance. Insulin resistance in subjects with type 2 diabetes and metabolic syndrome is primarily caused by an ectopic fat accumulation in liver and skeletal muscle. Insulin sensitizers are particularly important in the man...
Guan, Xiaoshu Jiang, Lan Cai, Linhong Zhang, Li Hu, Xiangnan
Published in
Molecules
A co-crystal of rosiglitazone (Rsg) with berberine (Bbr), Rsg-Bbr, was prepared by the solvent evaporation method and characterized. The results showed that the electrostatic attraction existed between the nitrogen anion of rosiglitazone and the quaternary ammonium cation of berberine, and C-H···O hydrogen bonds were formed between Rsg and Bbr. In ...
Li, Mingyang Hu, Jingwen Yao, Lihua Gao, Minzhi
Published in
Journal of cellular and molecular medicine
Insufficient endometrial angiogenesis during peri-implantation impairs endometrial receptivity (ER), which contributes to recurrent implantation failure (RIF) during in vitro fertilization and embryo transfer (IVF-ET). Angiopoietin-like protein 4 (ANGPTL4) acts as a multifunctional secretory protein and is involved in the regulation of lipid metabo...
GÜNDOĞDU, Burcu TAPISIZ, Ömer Lütfi DİLBAZ, Berna MÜLAZIMOĞLU, Serkan Barış MÜFTÜOĞLU, Kamil Hakan DÜNDAR, Betül GÖKTOLGA, Ümit
Published in
Turkish Journal of Medical Sciences
Background/aim To evaluate the effects of hysterectomy on rat ovaries and the possible protective role of peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist-rosiglitazone against ovarian reserve decrement. Materials and methods Forty-five adult Wistar albino rats were randomly divided into three groups. Hysterectomy was performed (n ...
