This PhD thesis aimed to provide additional evidence to demonstrate the potential of an integrated testing strategy using in vitro assays with physiologically based kinetic (PBK) modeling based-reverse dosimetry to predict in vivo toxicity without animal testing. Kidney toxicity was chosen as the toxicity endpoint and aristolochic acids (AAs) were ...
Currently, fungicides are necessary to protect potato crops against late blight, Phytophthora infestans, one of the world’s most damaging crop pathogens. The introgression of plant resistance genes from wild potato species targeted specifically to the late blight pathogen into susceptible potato varieties may alleviate the environmental impact of c...
Pesticide use and off-site risk assessment: a case study of glyphosate fate in Chinese Loess soil Xiaomei Yang Abstract: Repeated applications of pesticide may contaminate the soil and water, threatening their quality within the environmental system and beyond it through water erosion related processes and leaching. Taking into account the situatio...
Engineered nanoparticles (ENPs) are used everywhere and have large technological and economic potential. Like all novel materials, however, ENPs have no history of safe use. Insight into risks of nanotechnology and the use of nanoparticles is an essential condition for the societal acceptance and safe use of nanotechnology. Risk assessment of ENPs ...
The current increase in application rate and usage frequency of application of pesticides in Ethiopia pose direct risks to surface water aquatic organisms and humans and cattle using surface water as a source of drinking water in rural parts of the country. A model based risk assessment as currently being used in Europe and elsewhere in the world i...
Determination of safe human exposure levels of chemicals in toxicological risk assessments largely relies on animal toxicity data. In these toxicity studies, the highest number of animals are used for reproductive and developmental toxicity testing. Because of economic and ethical reasons, there is large interest in the development of in vitro and/...
Absorption of toxic substances via the skin is an important phenomenon in the assessment of the risk of exposure to these substances. People are exposed to a variety of substances and products via the skin, either directly or indirectly, while at work, at home or in public space. Pesticides, organic solvents and metalworking fluids are seen to be i...
Een beoordeling is uitgevoerd van 21 stoffen die door LTO-Noord en de Biogas Branche Organisatie (BBO)aangemeld zijn voor opname in bijlage Aa van de Uitvoeringsregeling Meststoffenwet. Op verzoek van het ministerieEZ zijn daar 6 stoffen aan toegevoegd (21+6) en werden 119 eerder aangemelde stoffen herbeoordeeld in metverband wijziging van de keuze...
Trudy M.A. Wijnhoven Overweight and obesity in primary-school children: a surveillance system for policy-making in Europe from 2007 onwards. Background As a follow-up to the European Ministerial Conference on Counteracting Obesity convened in 2006 in Turkey, the European Childhood Obesity Surveillance Initiative (COSI) was launched by the Regional ...
