de Campos, Viviane Souza Calaza, Karin C. Adesse, Daniel
Published in
Frontiers in Cellular and Infection Microbiology
There are certain critical periods during pregnancy when the fetus is at high risk for exposure to teratogens. Some microorganisms, including Toxoplasma gondii , are known to exhibit teratogenic effects, interfering with fetal development and causing irreversible disturbances. T. gondii is an obligate intracellular parasite and the etiological agen...
Savier, Elise Laura Dunbar, James Cheung, Kyle Reber, Michael
Published in
eLife
We previously identified and modeled a principle of visual map alignment in the midbrain involving the mapping of the retinal projections and concurrent transposition of retinal guidance cues into the superior colliculus providing positional information for the organization of cortical V1 projections onto the retinal map (Savier et al., 2017). This...
Akula, James D. Arellano, Ivana A. Swanson, Emily A. Favazza, Tara L. Bowe, Theodore S. Munro, Robert J. Ferguson, R. Daniel Hansen, Ronald M. Moskowitz, Anne Fulton, Anne B.
...
Published in
Investigative Ophthalmology & Visual Science
Purpose Because preterm birth and retinopathy of prematurity (ROP) are associated with poor visual acuity (VA) and altered foveal development, we evaluated relationships among the central retinal photoreceptors, postreceptor retinal neurons, overlying fovea, and VA in ROP. Methods We obtained optical coherence tomograms (OCTs) in preterm born subje...
Bell, Claire M. Zack, Donald J. Berlinicke, Cynthia A.
Recent advances in stem cell engineering have led to an explosion in the use of organoids as model systems for studies in multiple biological disciplines. Together with breakthroughs in genome engineering and the various omics, organoid technology is making possible studies of human biology that were not previously feasible. For vision science, ret...
Linderman, Rachel E Georgiou, Michalis Woertz, Erica N Cava, Jenna A Litts, Katie M Tarima, Sergey Rajendram, Ranjan Provis, Jan M Michaelides, Michel Carroll, Joseph
...
Published in
Investigative ophthalmology & visual science
To examine the foveal avascular zone (FAZ) in patients with congenital achromatopsia (ACHM). Forty-two patients with genetically confirmed ACHM were imaged either with Optovue's AngioVue system or Zeiss's Plex Elite 9000, and the presence or absence of a FAZ was determined. For images where a FAZ was present and could be confidently segmented, FAZ ...
Ge, Yichen Wu, Fuguo Cheng, Mobin Bard, Jonathan Mu, Xiuqian
Published in
Developmental dynamics : an official publication of the American Association of Anatomists
During development, all retinal cell types arise from retinal progenitor cells (RPCs) in a step-wise fashion. Atoh7 and Pou4f2 mark, and function in, two phases of retinal ganglion cell (RGC) genesis; Atoh7 functions in a subpopulation of RPCs to render them competent for the RGC fate, whereas Pou4f2 participates in RGC fate specification and RGC d...
Spencer, Peter S
Published in
Eye and brain
To reexamine the etiology of a unique retinal pathology (linear and vermiform sub-retinal tubular structures) described among subjects with and without neurodegenerative disease in former high-incidence foci of Western Pacific amyotrophic lateral sclerosis and parkinsonism-dementia complex (ALS/PDC) in Guam (USA) and the Kii peninsula of Honshu isl...
Volkov, Leo I. Kim-Han, Jeong Sook Saunders, Lauren M. Poria, Deepak Hughes, Andrew E. O. Kefalov, Vladimir J. Parichy, David M. Corbo, Joseph C.
Published in
Proceedings of the National Academy of Sciences of the United States of America
Thyroid hormone (TH) signaling plays an important role in the regulation of long-wavelength vision in vertebrates. In the retina, thyroid hormone receptor β ( thrb ) is required for expression of long-wavelength-sensitive opsin ( lws ) in red cone photoreceptors, while in retinal pigment epithelium (RPE), TH regulates expression of a cytochrome P45...
Wang, Yishen Wang, Xiao Jiang, Yukang Liu, Ruyuan Cao, Di Pan, Jianying Luo, Yan
Published in
Molecular Medicine Reports
MicroRNAs (miRNAs) are upstream regulators of gene expression and are involved in several biological processes. The purpose of the present study was to obtain a detailed spatiotemporal miRNA expression profile in mouse retina, to identify one or more miRNAs that are key to mouse retinal development and to investigate the roles and mechanisms of the...
Wu, Yihui Qiu, Jin Chen, Shuilian Chen, Xi Zhang, Jing Zhuang, Jiejie Liu, Sian Yang, Meng Zhou, Pan Chen, Haoting
...
Published in
Frontiers in Cell and Developmental Biology
Cone rod homeobox (Crx) plays a key role at the center of a regulatory network that coordinates many pathways in the retina. Its abnormal expression induces retinal disorders. However, the underlying regulatory mechanism of Crx expression is not well defined. Here, we present data that show that the levels of Crx mRNA were inconsistent with that of...
