Lorenzo, Melissa Lynch, Aine Ashkanase, Jenna Fazari, Linda George, Kristen Arathoon, Katelyn Minn, Sunghoon Nicolson, Dawn Jeewa, Aamir Jean-St-Michel, Emilie
...
Published in
Frontiers in Pediatrics
Introduction Children with restrictive cardiomyopathy (RCM) traditionally have a poor prognosis, with most patients either dying or requiring heart transplantation within 2 years of diagnosis. The development of symptoms in RCM suggests advanced disease. However, as screening practices evolve and lead to diagnosis of early disease, identifying appr...
Luo, Ying Li, Xiaoxiao Zhao, Yawei Zhong, Wen Xing, Malcolm Lyu, Guozhong
Published in
Pharmaceutics
Drugs may undergo costly preclinical studies but still fail to demonstrate their efficacy in clinical trials, which makes it challenging to discover new drugs. Both in vitro and in vivo models are essential for disease research and therapeutic development. However, these models cannot simulate the physiological and pathological environment in the h...
Oztarhan, Kazim Senturk, Beyza Ucar, Ozlem
Published in
Cardiology in the young
Left ventricular non-compaction is a very rare, still unclassified congenital cardiomyopathy. Nine distinct subtypes of functional and anatomical left ventricular non-compaction have been identified. Studies on the prognosis and mortality of subtypes are ongoing. Our study presented the first restrictive subtype left ventricular non-compaction case...
Wang, Bryan Nash, Trevor Zhang, Xiaokan Rao, Jenny Abriola, Laura Kim, Youngbin Zakharov, Sergey Kim, Michael Luo, Lori Morsink, Margaretha
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Restrictive cardiomyopathy (RCM) is defined as increased myocardial stiffness and impaired diastolic relaxation leading to elevated ventricular filling pressures. Human variants in filamin C (FLNC) are linked to a variety of cardiomyopathies, and in this study, we investigate an in-frame deletion (c.7416_7418delGAA, p.Glu2472_Asn2473delinAsp) in a ...
Monda, Emanuele Kaski, Juan Pablo Limongelli, Giuseppe
Published in
Frontiers in Pediatrics
Ji, Lianfu Chen, Jinlong Qin, Yuming Yang, Shiwei
Published in
Frontiers in Cardiovascular Medicine
Restrictive cardiomyopathy (RCM) is a rare form of heart muscle disease with poor prognosis. Its primary manifestations were caused by systemic or pulmonary circulation congestion. Here, we reported a case of RCM with ventricular fibrillation as initial symptom in a 7-year-old boy. The child suffered cardiac and respiratory arrest suddenly while ex...
Gordon, Jonathan S Blazoski, Cameron M Wood, Chelsey T Zuber, Charlotte Massey, Howard T Throckmorton, Amy Tchantchaleishvili, Vakhtang
Published in
Artificial organs
Restrictive cardiomyopathy (RCM) and hypertrophic cardiomyopathy (HCM) are two disease processes that are known to progress to heart failure with preserved ejection fraction (HFpEF). Pharmacologic therapies for HFpEF have not improved patient outcomes or reduced mortality in this patient cohort; thus, there continues to be substantial interest in o...
Aikawa, Tadao Ibe, Tatsuro Manabe, Osamu Oyama-Manabe, Noriko
Published in
Internal medicine (Tokyo, Japan)
Chatzileontiadou, Sofia Zegkos, Thomas Frouzaki, Christina Apsemidou, Athanasia Efthimiadis, Georgios Parcharidou, Despoina Papaioannou, Maria
Published in
Frontiers in Oncology
Cardiac amyloidosis (CA) represents a myocardial disorder developed by fibril deposition of a heterogeneous group of misfolding proteins. Despite being rare, a high clinical index of suspicion and novel advanced diagnostic methods seem to facilitate its early recognition. Currently nine types of cardiac amyloidosis have been described with AL and A...
Stoian, Marilena Bucur, Ionela Silviu, Seitan Scarlat, Gabriel Procopiescu, Bianca
Published in
Internal Medicine
Type 2 diabetic nephropathy may be the consequence of some non-diabetic form of renal disease, unlike type 1 diabetes mellitus (DM) of long duration (≥10 years) in which severe proteinuria is always related to a well -defined pattern of diabetic nephropathy. The clinical manifestations of diabetic nephropathy are similar in type 1 and type 2 diabet...
