Borisov, V. B.
Published in
Biochemistry (Moscow)
AbstractCytochrome bd-I is a terminal oxidase of the Escherichia coli respiratory chain. This integral membrane protein contains three redox-active prosthetic groups (hemes b558, b595, and d) and couples the electron transfer from quinol to molecular oxygen to the generation of proton motive force, as one of its important physiological functions. T...
Perovšek, Darko
Jenko, Klavdija
Franco, Leticia V. R. Bremner, Luca Barros, Mario H.
Published in
Life
The ease with which the unicellular yeast Saccharomyces cerevisiae can be manipulated genetically and biochemically has established this organism as a good model for the study of human mitochondrial diseases. The combined use of biochemical and molecular genetic tools has been instrumental in elucidating the functions of numerous yeast nuclear gene...
Wasmus, Christina Dudek, Jan
Published in
Life
The heart is the most energy-consuming organ in the human body. In heart failure, the homeostasis of energy supply and demand is endangered by an increase in cardiomyocyte workload, or by an insufficiency in energy-providing processes. Energy metabolism is directly associated with mitochondrial redox homeostasis. The production of toxic reactive ox...
Borisov, Vitaliy B Siletsky, Sergey A Paiardini, Alessandro Hoogewijs, David Forte, Elena Giuffrè, Alessandro Poole, Robert K
Published in
Antioxidants & redox signaling
Significance: Cytochrome bd is a ubiquinol:oxygen oxidoreductase of many prokaryotic respiratory chains with a unique structure and functional characteristics. Its primary role is to couple the reduction of molecular oxygen, even at submicromolar concentrations, to water with the generation of a proton motive force used for adenosine triphosphate p...
Piłsyk, Sebastian Mieczkowski, Adam Golan, Maciej P. Wawrzyniak, Agata Kruszewska, Joanna S.
Published in
International Journal of Molecular Sciences
The astA gene encoding an alternative sulfate transporter was originally cloned from the genome of the Japanese Aspergillus nidulans isolate as a suppressor of sulfate permease-deficient strains. Expression of the astA gene is under the control of the sulfur metabolite repression system. The encoded protein transports sulfate across the cell membra...
Liparulo, Irene Bergamini, Christian Bortolus, Marco Calonghi, Natalia Gasparre, Giuseppe Kurelac, Ivana Masin, Luca Rizzardi, Nicola Rugolo, Michela Wang, Wenping
...
Published in
The FEBS journal
Coenzyme Q10 (CoQ, ubiquinone) is a redox-active lipid endogenously synthesized by the cells. The final stage of CoQ biosynthesis is performed at the mitochondrial level by the "complex Q", where coq2 is responsible for the prenylation of the benzoquinone ring of the molecule. We report that the competitive coq2 inhibitor 4-nitrobenzoate (4-NB) dec...
山下, 皓平
The novel arylamidine T-2307 exhibits broad-spectrum in vitro and in vivo antifungal activities against clinically significant pathogens. Previous studies have shown that T-2307 accumulates in yeast cells via a specific polyamine transporter and disrupts yeast mitochondrial membrane potential. Further, it has little effect on rat liver mitochondria...
Naess, Karin Bruhn, Helene Stranneheim, Henrik Freyer, Christoph Wibom, Rolf Mourier, Arnaud Engvall, Martin Nennesmo, Inger Lesko, Nicole Wredenberg, Anna
...
Published in
The Journal of pediatrics
To evaluate the clinical symptoms and biochemical findings and establish the genetic etiology in a cohort of pediatric patients with combined deficiencies of the mitochondrial respiratory chain complexes. Clinical and biochemical data were collected from 55 children. All patients were subjected to sequence analysis of the entire mitochondrial genom...
