Understanding resistance to selective FGFR inhibitors is crucial to improve the clinical outcomes of patients with FGFR2-driven malignancies.
We analyzed sequential ctDNA, +/-WES or targeted NGS on tissue biopsies from patients with tumors harboring activating FGFR2 alterations progressing on pan-FGFR-selective inhibitors, collec...
Published in Clinical cancer research : an official journal of the American Association for Cancer Research
Understanding resistance to selective FGFR inhibitors is crucial to improve the clinical outcomes of patients with FGFR2-driven malignancies. We analyzed sequential ctDNA, +/- WES or targeted NGS on tissue biopsies from patients with tumors harboring activating FGFR2 alterations progressing on pan-FGFR-selective inhibitors, collected in the prospec...
Published in Journal of biomolecular structure & dynamics
FMS-like tyrosine kinase (FLT3) has become the legitimate molecular therapeutic target for acute myeloid leukemia therapy. Though FLT3 inhibitors have impact on disease progression, drug resistance induced by secondary point mutations is the primary mechanism and urgent to overcome. Herein, we sought to decipher the mechanism of HM43239 inhibiting ...
Published in Frontiers in Pharmacology
Plant pathogens cause significant crop damages and yield losses each year. Rice bacterial blight and rice blast have the most dominant and destructive effects on rice production and quality. In plants, genes encoding valine glutamine (VQ)-motif containing proteins play an important role in plant defense responses. The objectives of this thesis are ...
peer reviewed / Cyanobacteria inhabit extreme environments, including drylands, providing multiple benefits to the ecosystem. Soil degradation in warm drylands is increasing due to land use intensification. Restoration methods adapted to the extreme stress in drylands are being developed, such as cyanobacteria inoculation to recover biocrusts. For ...
Published in Frontiers in Microbiology
Acinetobacter baumannii is one of the most common multidrug-resistant pathogens causing nosocomial infections. The prevalence of multidrug-resistant A. baumannii infections is increasing because of several factors, including unregulated antibiotic use. A. baumannii drug resistance rate is high; in particular, its resistance rates for tigecycline an...
Introduction. Quinoa downy mildew is a disease that causes great economic losses and has been little studied, so research on the response of quinoa to the disease and forms of treatment is a topic that should be investigated in greater depth. Objective. To describe how downy mildew infection affects the quinoa plant and the non-traditional methods ...
Published in Current medicinal chemistry
MET (MET Proto-Oncogene, Receptor Tyrosine Kinase) exon 14 skipping mutation represents one of the most common MET alterations, accounting for approximately 1-3% of all mutations in advanced lung adenocarcinomas. While until 2020 no specific treatment was available for this subset of patients, as of today, three MET Tyrosine Kinase Inhibitors (TKIs...
Published in Frontiers in Pharmacology
Fusions and mutations of anaplastic lymphoma kinase (ALK), a tyrosine kinase receptor, have been identified in several neoplastic diseases. Rearranged ALK is a driver of tumorigenesis, which activates various signaling pathway associated with proliferation and survival. To date, several agents that target and inhibit ALK have been developed. The mo...
