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with replicative stress response as keyword
Sundararajan, Vignesh Tan, Tuan Zea Lim, Diana Peng, Yanfen Wengner, Antje Margret Ngoi, Natalie Yan Li Jeyasekharan, Anand D Tan, David Shao Peng
Published in
The Journal of pathology
Excessive genomic instability coupled with abnormalities in DNA repair pathways induces high levels of 'replication stress' when cancer cells propagate. Rather than hampering cancer cell proliferation, novel treatment strategies are turning their attention towards targeting cell cycle checkpoint kinases (such as ATR, CHK1, WEE1, and others) along t...
Ngoi, Natalie Y L Pham, Melissa M Tan, David S P Yap, Timothy A
Published in
Trends in cancer
The replication stress response (RSR) involves a downstream kinase cascade comprising ataxia telangiectasia-mutated (ATM), ATM and rad3-related (ATR), checkpoint kinases 1 and 2 (CHK1/2), and WEE1-like protein kinase (WEE1), which cooperate to arrest the cell cycle, protect stalled forks, and allow time for replication fork repair. In the presence ...
