Picerno, Angela Giannuzzi, Francesca Curci, Claudia De Palma, Giuseppe Di Chiano, Mariagiovanna Simone, Simona Franzin, Rossana Gallone, Anna Di Lorenzo, Vito Francesco Stasi, Alessandra
...
Published in
Stem cells (Dayton, Ohio)
The long non-coding RNAs (lncRNA) play an important role in several biological processes, including some renal diseases. Nevertheless, little is known about lncRNA that are expressed in the healthy kidneys and involved in renal cell homeostasis and development, and even less is known about lncRNA involved in the maintenance of human adult renal ste...
Guo, Haibin Deng, Nan Dou, Lei Ding, Huifen Criswell, Tracy Atala, Anthony Furdui, Cristina M. Zhang, Yuanyuan
Published in
ACS biomaterials science & engineering
Wu, Di Bai, Jiuxu Cui, Shaoyuan Fu, Bo Yin, Zhiwei Cai, Guangyan Chen, Xiangmei
Published in
Annals of translational medicine
Mesangial proliferative glomerulonephritis (MsPGN) is an epidemic disease with increasing occurrence. As important as mesangial cells, podocytes are key innate cells for MsPGN prognosis and recovery. Renal progenitor cells, located at the urinary pole (UP) of Bowman's capsule (BC), could alleviate kidney injury through their capacity to differentia...
Melica, Maria Elena La Regina, Gilda Parri, Matteo Peired, Anna Julie Romagnani, Paola Lasagni, Laura
Published in
Cells
Stem cell (SC)-based tissue engineering and regenerative medicine (RM) approaches may provide alternative therapeutic strategies for the rising number of patients suffering from chronic kidney disease. Embryonic SCs and inducible pluripotent SCs are the most frequently used cell types, but autologous patient-derived renal SCs, such as human CD133+C...
Becherucci, Francesca Mazzinghi, Benedetta Allinovi, Marco Angelotti, Maria Lucia Romagnani, Paola
Published in
Expert opinion on biological therapy
Chronic kidney disease is a major health-care problem worldwide and its cost is becoming no longer affordable. Indeed, restoring damaged renal structures or building a new kidney represents an ambitious and ideal alternative to renal replacement therapy. Streams of research have explored the possible application of pluripotent stem cells (SCs) (emb...
Sallustio, Fabio Serino, Grazia Schena, Francesco Paolo
Published in
BioResearch open access
Human kidney is particularly susceptible to ischemia and toxins with consequential tubular necrosis and activation of inflammatory processes. This process can lead to the acute renal injury, and even if the kidney has a great capacity for regeneration after tubular damage, in several circumstances, the normal renal repair program may not be suffici...
Lazzeri, Elena Romagnani, Paola Lasagni, Laura
Published in
Expert opinion on biological therapy
Stem cell therapy is a promising new treatment for kidney disease documented in many animal studies. Mesenchymal stem cells have emerged as a promising cell type, but their efficacy in clinical trials is still controversial. Identification of progenitor cells in the adult kidney is another step forward in regenerative medicine, suggesting the repai...
Grange, Cristina Moggio, Aldo Tapparo, Marta Porta, Stefano Camussi, Giovanni Bussolati, Benedetta
Published in
Physiological reports
Abstract Recent approaches of regenerative medicine can offer a therapeutic option for patients undergoing acute kidney injury. In particular, mesenchymal stem cells were shown to ameliorate renal function and recovery after acute damage. We here evaluated the protective effect and localization of CD133(+) renal progenitors from the human inner med...
Adams, Derek C Oxburgh, Leif
Published in
American journal of physiology. Renal physiology
Long-term pulse chase experiments previously identified a sizable population of BrdU-retaining cells within the renal papilla. The origin of these cells has been unclear, and in this work we test the hypothesis that they become quiescent early during the course of kidney development and organ growth. Indeed, we find that BrdU-retaining cells of the...
