Ssemaganda, Aloysious Cholette, Francois Perner, Michelle Kambaran, Cheli Adhiambo, Wendy Wambugu, Peter M. Gebrebrhan, Henok Lee, Amy Nuhu, Faisal Mwatelah, Ruth S.
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Published in
Frontiers in Immunology
Regulatory T cells (Tregs) play important roles in tissue homeostasis, but few studies have investigated tissue Tregs in the context of genital inflammation, HIV target cell density, and vaginal microbiota in humans. In women from Nairobi (n=64), the proportion of CD4+ CD25+ CD127low Tregs in the endocervix correlated with those in blood (r=0.31, p...
Sjaastad, Louisa E. Owen, David L. Tracy, Sean I. Farrar, Michael A.
Published in
Frontiers in Cell and Developmental Biology
The concept that a subset of T cells exists that specifically suppresses immune responses was originally proposed over 50 years ago. It then took the next 30 years to solidify the concept of regulatory T cells (Tregs) into the paradigm we understand today – namely a subset of CD4+ FOXP3+ T-cells that are critical for controlling immune responses to...
Yu, Wenqing Ji, Ningfei Gu, Chengjing Yao, Juan Ding, Mingdong Zhou, Daming Huang, Mao Zhang, Mingshun
Published in
International Journal of General Medicine
Background RORγt+Foxp3+ (Th17-like) Tregs are a plastic Treg subset implicated in immune-related diseases; however, the mechanism of Treg phenotypic transformation in malignant pleural effusion (MPE) has not been elucidated. Methods The percentage of CD4+CD25+Foxp3+Helios+ and RORγt+Foxp3+ Tregs from peripheral blood and pleural effusion mononuclea...
Nicholls, Jemma Cao, Benjamin Le Texier, Laetitia Xiong, Laura Yan Hunter, Christopher R. Llanes, Genesis Aguliar, Ethan G. Schroder, Wayne A. Phipps, Simon Lynch, Jason P.
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Published in
Frontiers in Cell and Developmental Biology
Regulatory T cell (Treg) reconstitution is essential for reestablishing tolerance and maintaining homeostasis following stem-cell transplantation. We previously reported that bone marrow (BM) is highly enriched in autophagy-dependent Treg and autophagy disruption leads to a significant Treg loss, particularly BM-Treg. To correct the known Treg defi...
Sefik, Esen Hori, Shohei Vasanthakumar, Ajithkumar
Published in
Frontiers in Immunology
Muller, Yannick D. Ferreira, Leonardo M. R. Ronin, Emilie Ho, Patrick Nguyen, Vinh Faleo, Gaetano Zhou, Yu Lee, Karim Leung, Kevin K. Skartsis, Nikolaos
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Published in
Frontiers in Immunology
Infusion of regulatory T cells (Tregs) engineered with a chimeric antigen receptor (CAR) targeting donor-derived human leukocyte antigen (HLA) is a promising strategy to promote transplant tolerance. Here, we describe an anti-HLA-A2 CAR (A2-CAR) generated by grafting the complementarity-determining regions (CDRs) of a human monoclonal anti-HLA-A2 a...
Chao, Jaime L. Korzinkin, Michael Zhavoronkov, Alex Ozerov, Ivan V. Walker, Matthew T. Higgins, Kathleen Lingen, Mark W. Izumchenko, Evgeny Savage, Peter A.
Published in
Cell Reports Medicine
Chao et al. demonstrate that HPV-negative oral squamous cell carcinomas (OSCCs) are characterized by polarized clusters enriched for CD8+ or CD4+ T cells. In a mouse model of carcinogen-induced OSCC, late-stage depletion of regulatory T cells promotes the emergence of invasive OSCCs via an effector T cell-dependent process.
Wen, Xiumei He, Beihui Tang, Xing Wang, Bin Chen, Zhiyun
Published in
Molecular Medicine Reports
Acute pancreatitis (AP) is one of the most frequent gastrointestinal diseases and has no specific treatment. It has been shown that dysfunction of pancreatic acinar cells can lead to AP progression. Emodin is a natural product, which can alleviate the symptoms of AP. However, the mechanism by which emodin regulates the function of pancreatic acinar...
hefazi, mehrdad bolivar-wagers, sara blazar, bruce r.
Graft-versus-host disease (GVHD) is the leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Immunomodulation using regulatory T cells (Tregs) offers an exciting option to prevent and/or treat GVHD as these cells naturally function to maintain immune homeostasis, can induce tolerance followi...
Weerakoon, Harshi Straube, Jasmin Lineburg, Katie Cooper, Leanne Lane, Steven Smith, Corey Alabbas, Saleh Begun, Jakob Miles, John J Hill, Michelle M
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Published in
Clinical & Translational Immunology
This study defines two distinct subsets of effector regulatory T cells (Treg) circulating in the human blood based on the presence or absence of CD49f with divergent transcriptional landscape and functional activities. CD49f– Treg are enriched for functional Treg markers and present significantly increased suppressive capacity whilst CD49fhigh Treg...
