Moore, Tyler C Hasenkrug, Kim J
Published in
Journal of molecular biology
B lymphocytes have well-established effector roles during viral infections, including production of antibodies and functioning as antigen-presenting cells for CD4+ and CD8+ T cells. B cells have also been shown to regulate immune responses and induce regulatory T cells (Tregs). In the Friend virus (FV) model, Tregs are known to inhibit effector CD8...
Yildirim, Zeynep Karabekiroglu, Koray Yildiran, Alisan Celiksoy, Mehmet Halil Artukoglu, Bekir Baykal, Saliha Babadağı, Zehra Leckman, James
Published in
Nordic journal of psychiatry
Tourette syndrome (TS) is a childhood-onset neurodevelopmental disorder characterized by several motor and phonic tics. In this study, we aimed to compare activated regulatory T cell (Treg) values between patients with TS/chronic tic disorder (CTD) and age- and sex-matched healthy controls (HCs). Patients with TS/CTD and age- and sex-matched HCs we...
Gong, Jialei Zeng, Qunxiong Yu, Di Duan, Yong-Gang
Published in
International journal of molecular sciences
The immune privilege of the testes is necessary to prevent immune attacks to gamete-specific antigens and paternal major histocompatibility complex (MHC) antigens, allowing for normal spermatogenesis. However, infection and inflammation of the male genital tract can break the immune tolerance and represent a significant cause of male infertility. D...
Xiao, Hongyu Fang, Zhi He, Xueling Ding, Ping Cao, Yongkai Chan, Shamyuen Hou, Shaozhen Liang, Jian
Published in
The Journal of pharmacy and pharmacology
To explore the effect of recombinant LZ-8 (rLZ-8) on streptozocin (STZ)-induced diabetic rats and further illustrate its underlying mechanism. Rats were intraperitoneally injected with single-dose STZ 50 mg/kg for induction of type 1 diabetes (T1D), and then, the diabetic rats were treated with rLZ-8 for 3 months. The clinical symptoms, fasting blo...
Basak, Preetam Sachdeva, Naresh Dayal, Devi
Published in
BioEssays : news and reviews in molecular, cellular and developmental biology
As the number of infections and mortalities from the SARS-CoV-2 pandemic continues to rise, the development of an effective therapy against COVID-19 becomes ever more urgent. A few reports showing a positive correlation between BCG vaccination and reduced COVID-19 mortality have ushered in some hope. BCG has been suggested to confer a broad level o...
Zhang, Qunfang Huang, Haiding Zheng, Fang Liu, Huazhen Qiu, Feifei Chen, Yuchao Liang, Chun-Ling Dai, Zhenhua
Published in
Oncoimmunology
CD4+Foxp3+ regulatory T cells (Tregs) in the tumor microenvironment restrain antitumor immunity, resulting in tumor aggression and poor survival in hepatocellular carcinoma (HCC). CD8+CD122+ Tregs have been previously shown to be more potent in immunosuppression than are CD4+Foxp3+ Tregs. Previous studies have demonstrated that resveratrol exerts i...
Oshi, Masanori Asaoka, Mariko Tokumaru, Yoshihisa Angarita, Fernando A. Yan, Li Matsuyama, Ryusei Zsiros, Emese Ishikawa, Takashi Endo, Itaru Takabe, Kazuaki
...
Published in
Cancers
Simple Summary Regulatory CD4+ T cell (Treg) is one of the suppressive immune cells, but data on its clinical relevance in large human breast cancer cohort is limited. Abundance of Tregs in 5177 breast cancer patient samples from five independent cohorts was analyzed by the xCell algorithm using tumor transcriptomics. Treg abundance was lower in me...
Turner, Jacob A Stephen-Victor, Emmanuel Wang, Sen Rivas, Magali Noval Abdel-Gadir, Azza Harb, Hani Cui, Ye Fanny, Manoussa Charbonnier, Louis-Marie Fong, Jason Jun Hung
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Published in
Immunity
The mechanisms by which regulatory T (Treg) cells differentially control allergic and autoimmune responses remain unclear. We show that Treg cells in food allergy (FA) had decreased expression of transforming growth factor beta 1 (TGF-β1) because of interleukin-4 (IL-4)- and signal transducer and activator of transciription-6 (STAT6)-dependent inhi...
Huang, Shile
Published in
Cells
The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. The papers published in this special issue summarize the current understandin...
Pfeil, Jennifer Simonetti, Mario Lauer, Uta Volkmer, Rudolf von Thülen, Bianca Durek, Pawel Krähmer, Ralf Leenders, Frank Hamann, Alf Hoffmann, Ute
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Published in
Frontiers in Immunology
Current treatments for autoimmune disorders rely on non-specific immunomodulatory and global immunosuppressive drugs, which show a variable degree of efficiency and are often accompanied by side effects. In contrast, strategies aiming at inducing antigen-specific tolerance promise an exclusive specificity of the immunomodulation. However, although ...