Awada, Gil Jansen, Yanina Schwarze, Julia Katharina Tijtgat, Jens Hellinckx, Lennert Gondry, Odrade Vermeulen, Sim Warren, Sarah Schats, Kelly van Dam, Pieter-Jan
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Published in
Cancers
Pembrolizumab improves the survival of patients with advanced melanoma. A comprehensive analysis of baseline variables that predict the benefit of pembrolizumab monotherapy has not been conducted. Survival data of patients with advanced melanoma who were treated with pembrolizumab in a single university hospital were collected. A multivariate Cox r...
Mohammad-Sidik, Amirah Sun, Jian Shin, Ryoung Song, Zhizhong Ning, Youzheng Matthus, Elsa Wilkins, Katie A Davies, Julia M
Published in
International journal of molecular sciences
Extracellular ATP (eATP) has long been established in animals as an important signalling molecule but this is less understood in plants. The identification of Arabidopsis thaliana DORN1 (Does Not Respond to Nucleotides) as the first plant eATP receptor has shown that it is fundamental to the elevation of cytosolic free Ca2+ ([Ca2+]cyt) as a possibl...
Awad, Kamal Ahuja, Neelam Fiedler, Matthew Peper, Sara Wang, Zhiying Aswath, Pranesh Brotto, Marco Varanasi, Venu
Published in
International journal of molecular sciences
Volumetric muscle loss injuries overwhelm the endogenous regenerative capacity of skeletal muscle, and the associated oxidative damage can delay regeneration and prolong recovery. This study aimed to investigate the effect of silicon-ions on C2C12 skeletal muscle cells under normal and excessive oxidative stress conditions to gain insights into its...
Ježek, Jan Cooper, Katrina F. Strich, Randy
Cancer is one of the world’s deadliest afflictions. Despite recent advances in diagnostic and surgical technologies, as well as improved treatments of some individual tumor types, there is currently no universal cure to prevent or impede the uncontrolled proliferation of malignant cells. Targeting tumors by inducing apoptosis is one of the pillars ...
Mohammad-Sidik, Amirah Sun, Jian Shin, Ryoung Song, Zhizhong Ning, Youzheng Matthus, Elsa Wilkins, Katie A. Davies, Julia M.
Extracellular ATP (eATP) has long been established in animals as an important signalling molecule but this is less understood in plants. The identification of Arabidopsis thaliana DORN1 (Does Not Respond to Nucleotides) as the first plant eATP receptor has shown that it is fundamental to the elevation of cytosolic free Ca2+ ([Ca2+]cyt) as a possibl...
Canaparo, Roberto Foglietta, Federica Limongi, Tania Serpe, Loredana
The design, synthesis and characterization of new nanomaterials represents one of the most dynamic and transversal aspects of nanotechnology applications in the biomedical field. New synthetic and engineering improvements allow the design of a wide range of biocompatible nanostructured materials (NSMs) and nanoparticles (NPs) which, with or without...
Shaker, Sharpkate Sun, Ting-Ting Wang, Liang-Yue Ma, Wen-Zhe Wu, Dong-Lan Guo, Yong-Wei Dong, Jun Chen, Yan-Xiu Zhu, Long-Ping Yang, De-Po
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Published in
Natural product research
To investigate the influence of reactive oxygen species (ROS) on the secondary metabolites of the marine-derived fungus Dichotomomyces cejpii F31-1, hydrogen peroxide (H2O2) was added to the GPY culture medium. The HPLC chromatogram of the EtOAc extract of the culture broth was distinct from that of the H2O2 free GPY medium. Further study of the me...
Joniová, Jaroslava Wagnières, Georges
Published in
Journal of Biomedical Optics
Significance: Side effects of many cancer treatments are associated with the production of reactive oxygen species (ROS) in normal tissues. This explains why patients treated by photodynamic therapy (PDT) often suffer from skin photosensitization, whereas those subject to radiotherapies frequently experience damages in various organs, including the...
Andrianova, N. V. Zorov, D. B. Plotnikov, E. Y.
Published in
Biochemistry (Moscow)
AbstractInflammation and oxidative stress are the main pathological processes that accompany ischemic injury of kidneys and other organs. Based on this, these factors are often chosen as a target for treatment of acute kidney injury (AKI) in a variety of experimental and clinical studies. Note, that since these two components are closely interrelat...
Andreyev, A. Y. Kushnareva, Y. E. Starkova, N. N. Starkov, A. A.
Published in
Biochemistry (Moscow)
AbstractMetabolism is a critical determinant of immune cell functionality. Immunometabolism, by definition, is a multidisciplinary area of immunology research that integrates the knowledge of energy transduction mechanisms and biochemical pathways. An important concept in the field is metabolic switch, a transition of immune cells upon activation t...
