Alizamani, Ehsan Ghorbanzadeh, Behnam Naserzadeh, Reza Mansouri, Mohammad Taghi
Published in
The International journal of neuroscience
The leukotrienes are inflammatory mediators. In the present study, the analgesic role of local montelukast, a cysteinyl leukotriene receptor antagonist, and the possible involvement of L-arginine/NO/cGMP/KATP channel pathway and PPARγ receptors was assessed in the formalin test in rats. The local administration of montelukast into the hind paw prod...
Paglia, David N Kanjilal, Deboleena Kadkoy, Yazan Moskonas, Spiro Wetterstrand, Charlene Lin, Anthony Galloway, Joseph Tompson, Jeffrey Culbertson, Maya D O'Connor, J Patrick
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Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
The effects of naproxen, a nonsteroidal anti-inflammatory drug (NSAID), on articular cartilage degeneration in female Sprague-Dawley rats was examined. Osteoarthritis (OA) was induced by destabilization of the medial meniscus (DMM) in each knee. Rats were treated with acetaminophen (60 mg/kg), naproxen (8 mg/kg), or 1% carboxymethylcellulose (place...
Ekizceli, G Halk, K Z Minbay, Z Eyigor, O
Published in
Biotechnic & histochemistry : official publication of the Biological Stain Commission
Nesfatin-1 and neuronostatin in the central nervous system participate in regulating stress responses. Glucocorticoid hormones affect the brain through glucocorticoid receptors (GR). We investigated in the rat the possibility of co-localizing nesfatin-1 and neuronostatin neurons in hypothalamic areas with GR. using immunohistochemistry. We counted ...
Nicolas, Fourcaud-Trocmé Mickaël, Zbili Patricia, Duchamp-Viret Nicola, Kuczewski
Abstract In the olfactory bulb (OB), mitral cells (MCs) display a spontaneous firing that is characterized by bursts of action potentials intermixed with silent periods. Burst firing frequency and duration are heterogeneous among MCs and increase with membrane depolarization. By using patch clamp recording on rat slices, we dissected out the intrin...
Personne, Stéphane Brochot, Céline Marcelo, Paulo Corona, Aurélie Desmots, Sophie Robidel, Franck Lecomte, Anthony Bach, Véronique Zeman, Florence
Published in
Frontiers in Pediatrics
Biomonitoring studies have highlighted the exposure of pregnant women to pyrethroids based on the measurement of their metabolites in urine. Pyrethroids can cross the placental barrier and be distributed in the fetus as some pyrethroids were also measured in the meconium of newborns. Prenatal exposure to pyrethroids is suspected to alter the neurod...
Rankovic, Marina Draginic, Nevena Jeremic, Jovana Samanovic, Andjela Milojevic Stojkov, Svetlana Mitrovic, Slobodanka Jeremic, Nevena Radonjic, Tanja Srejovic, Ivan Bolevich, Sergey
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Published in
Frontiers in Physiology
Up until now, the specific mechanisms involved in doxorubicin (DOX)-induced cardiotoxicity have not been fully elucidated. Since thiamine deficiency is associated with myocardial dysfunction and it may lead to cardiomyopathy, we aimed to investigate whether thiamine (Vitamin B1) treatment provides cardioprotection and modulates DOX mediated subchro...
Dankis, Martin Carlsson, Thomas Aronsson, Patrik Tobin, Gunnar Winder, Michael
Published in
Investigative Ophthalmology & Visual Science
Purpose The functional characteristics of receptors that regulate lacrimal gland myoepithelial cells are still somewhat unclear. To date, mainly muscarinic receptors have been of interest; however, further knowledge is needed regarding their expression and functional roles. For this purpose, primary cultures of rat lacrimal gland myoepithelial cell...
guillen, kévin comby, pierre-olivier chevallier, olivier salsac, anne-virginie loffroy, romaric
Cyanoacrylates were first used for medical purposes during World War II to close skin wounds. Over time, medical applications were developed, specifically in the vascular field. Uses now range from extravascular instillation in vascular grafting to intravascular injection for embolization. These applications were made possible by the conduct of num...
hendawy, hanan kaneda, masahiro metwally, elsayed shimada, kazumi tanaka, takashi tanaka, ryou
Mesenchymal stem cells (MSCs) derived from adipose tissue are evolved into various cell-based regenerative approaches. Adipose-derived stem cells (ASCs) isolated from rats are commonly used in tissue engineering studies. Still, there is a gap in knowledge about how the harvest locations influence and guide cell differentiation. This study aims to i...
Sicotte, Benoit Brochu, Michèle
Published in
Frontiers in Physiology
Fetal growth needs adequate blood perfusion from both sides of the placenta, on the maternal side through the uterine vessels and on the fetal side through the umbilical cord. In a model of intrauterine growth restriction (IUGR) induced by reduced blood volume expansion, uterine artery remodeling was blunted. The aim of this study is to determine i...
